HydroTrend numerically simulates the flux of water and sediment delivered to the coastal ocean on a daily timescale, based on drainage-basin and climate characteristics. The model predicts how a river may have behaved in the geological past, provided that appropriate assumptions are made regarding past climate and drainage-basin properties.HydroTrend is applied to simulate a high-resolution discharge and sediment flux record for the Po River in Italy since the Last Glacial Maximum (LGM). A validation experiment of 12 years duration under present conditions shows a high correlation (r 2 = 0.72) with 12 years observed daily discharge. Monthly variations in simulated Po River discharge and sediment discharge for this same time period show an even closer agreement (r 2 = 0.97) with the observed data.Community Climate System models (CCSM) indicate that during the LGM the Po drainage-basin climate was much colder and drier than at present. The drainage basin itself was much larger due to a lower sea level. The Bølling period is shown to be an exceptional period in our model study, with significantly higher discharges and sediment loads, as glacier ablation was more dominant.HydroTrend simulations predict an average suspended sediment flux of 46.6 Mt yr −1 and an average bedload of 0.83 Mt yr −1 for the Po River during the Late Pleistocene (21-10 cal. kyr BP). This is ∼75% greater than in the Holocene (10-0 cal. kyr BP), where simulations indicate a suspended sediment flux of 26.7 Mt yr −1 and a bedload of 0.53 Mt yr −1 . The Würm Stadial simulations tend to show the highest suspendedsediment concentrations. However, when considering sediment yield where load is normalized to unit area (mass per square kilometre per time), simulations indicate slightly higher yield for the Holocene as compared with the Late Pleistocene, respectively 336 t km −2 yr −1 versus 283 t km −2 yr −1 , due to an increase in Holocene precipitation. Despite the overall lower yields during the Pleistocene, the model indicates that glacial influence is a dominant factor on the total sediment flux to the ocean.