Short-Term Breast Cancer Prediction by Random Periareolar Fine-Needle Aspiration Cytology and the Gail Risk Model

Fabian, Carol J.; Kimler, Bruce F.; Zalles, Carola M.; Klemp, Jennifer R.; Kamel, Sahar; Zeiger, Sandy; Mayo, Matthew S.

doi:10.1093/jnci/92.15.1217

Cited by 255 publications

(262 citation statements)

References 83 publications

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“…1,2 In the few studies that have examined the breast cancer risk associated with cytologic atypia, a finding of cytologic atypia was associated with a breast cancer risk similar to that reported in women with a finding of atypical hyperplasia on examination of histologic sections. 2,3 Although the cytologic criteria used to categorize intraductal epithelial changes are well defined, they have not been uniformly applied, and they have not been proven to be reproducible. 4,5 In studies that have compared cytologic findings of atypia with histologic findings from corresponding tissue, the correlation was poor and the rate of false-positive results high.…”

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confidence: 75%

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Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

et al. 2006

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Cytologic evaluation of ductal lavage or random periareolar fine-needle aspiration (FNA) specimens has been proposed to improve risk stratification of women at high risk for breast cancer. However, cytologic assessment of morphologic changes is subjective. To assess the utility of fluorescence in situ hybridization (FISH) in the categorization of breast lesions, we prospectively evaluated 32 random periareolar FNA specimens from 27 women at high risk for breast cancer. Cytologic specimens were prepared using the thin preparation technique, and diagnoses were made on the basis of previously published criteria. Specimens were also evaluated by FISH for chromosomes 1, 8, 11, and 17. Monosomy was defined as the loss of one signal or both signals in 420% of cells, and polysomy was defined as the presence of Z3 signals in 46% of cells. Cytologic smears from seven invasive ductal carcinomas and nine benign breast specimens from women at low risk for breast cancer were included for comparison. In the high-risk group, cytologic findings were nonproliferative epithelium (NPE) in 16 cases and hyperplasia in 16 cases. Chromosomal aberrations were detected in 11 (69%) of 16 NPE cases, 14 (89%) of 16 hyperplasia cases, seven (100%) of seven carcinoma cases, and none of the low-risk cases. Highrisk cases had significantly more monosomy of chromosomes 1, 11, and 17 and polysomy of chromosome 8 compared to low-risk cases and significantly less polysomy of chromosomes 1, 8, 11, and 17 compared to patients with cancer. There were no significant differences in monosomy or polysomy of individual chromosomes or a combination of chromosomes between the NPE and hyperplasia groups. This study shows that aberrations of chromosome number are common in high-risk women irrespective of cytologic findings. Studies evaluating the association between specific patterns of chromosomal polysomy and progression to malignancy may be warranted.

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confidence: 75%

“…In all women, random periareolar FNA was performed four times each at the 3 o'clock and 9 o'clock positions in each breast as previously described. 2 Briefly, a 1.5-inch, 23-gauge needle attached to a 10-ml syringe was used. The needle was inserted approximately 1-2 cm away from the areola, at 3 o'clock and later at 9 o'clock.…”

Section: Fine-needle Aspirationmentioning

confidence: 99%

Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

et al. 2006

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“…29). We have previously reported that, independent of the Gail risk model (30), women whose RPFNA specimens exhibit hyperplasia with atypia were five times more likely to develop ductal carcinoma in situ (DCIS) or invasive breast cancer within 4 years, compared with women without evidence of atypia (29).…”

Section: Introductionmentioning

confidence: 99%

“…We have previously reported that, independent of the Gail risk model (30), women whose RPFNA specimens exhibit hyperplasia with atypia were five times more likely to develop ductal carcinoma in situ (DCIS) or invasive breast cancer within 4 years, compared with women without evidence of atypia (29). RPFNA atypia fulfills the criteria of a good risk biomarker for breast cancer, in that it is biologically related, statistically associated, obtained easily, and, most importantly, reversible (29,31). We hypothesized that women with lower intakes and levels of omega-3 relative to omega-6 fatty acids in their blood and breast tissue would be more likely to exhibit RPFNA atypia.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 and Omega-6 Fatty Acids in Blood and Breast Tissue of High-Risk Women and Association with Atypical Cytomorphology

Hidaka

Harvey

et al. 2015

Cancer Prevention Research

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The ratio of omega-3 to omega-6 fatty acids, especially the longchain eicosapentaenoic acid (EPA) þ docosahexaenoic acid (DHA) to arachidonic acid (AA) ratio, is inversely associated with breast cancer risk. We measured the association between cytologic atypia, a biomarker for short-term risk of breast cancer development, and omega-3 and omega-6 fatty acid intake and levels in blood and breast tissue. Blood and benign breast tissue, sampled by random periareolar fine-needle aspiration (RPFNA), was obtained from 70 women at elevated risk for breast cancer. Self-reported dietary intake was assessed by the NCI's Food Frequency Questionnaire. The fatty acid composition of five lipid compartments, red blood cell, plasma and breast phospholipids, and plasma and breast triaclyglycerides (TAG), was analyzed by gas chromatography as weight percent. Median daily intakes of EPAþDHA and total omega-3 fatty acids were 80 mg and 1.1 g, respectively. The median total omega-3:6 intake ratio was 1:10. Compared with women without atypia, those with cytologic atypia had lower total omega-3 fatty acids in red blood cell and plasma phospholipids and lower omega-3:6 ratios in plasma TAGs and breast TAGs (P < 0.05). The EPAþDHA:AA ratio in plasma TAGs was also lower among women with atypia. This is the first report of associations between tissue levels of omega-3 and omega-6 fatty acids and a reversible tissue biomarker of breast cancer risk. RPFNA cytomorphology could serve as a surrogate endpoint for breast cancer prevention trials of omega-3 fatty acid supplementation. Cancer Prev Res; 8(5); 359-64. Ó2015 AACR.

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“…Two prospective studies with long-term follow-up have shown independently that women with cellular atypia detected in breast ductal cytology have an approximately five-fold increased relative risk of developing breast carcinoma. 27,28 The clinical significance of identifying atypia in an increased-risk cohort is unclear but may translate into a decrease in breast carcinoma incidence if appropriate interventions are developed and implemented in the future.…”

mentioning

confidence: 99%

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Hartman

Daniel

Kurian

et al. 2004

Cancer

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Surface tension and viscosity are the important properties of liquid binders affecting wet granulation processes. They could be used to control solids flow pattern and relative motion of particles for controlling wetting, granule growth, consolidation, and breakage. This study aims to investigate experimentally the impacts of the two properties with a conical high shear granulator. The results show significant effects of viscosity and surface tension on solids flow pattern and relative motion of particles. The relative importance of the two parameters, the surface tension and the viscosity, are found to vary with the axial and radial positions in the granulator. For example, the viscosity force decreases with an increase in the bed height in the axial direction (vertical plane). The viscosity force between particles coated with PEG4000 solution is in mN order, whereas that between particles coated with ethanol and water is in μN order. © 2009 American Institute of Chemical Engineers AIChE J, 2009

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Short-Term Breast Cancer Prediction by Random Periareolar Fine-Needle Aspiration Cytology and the Gail Risk Model

Cited by 255 publications

References 83 publications

Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

Correlation of cytologic findings and chromosomal instability detected by fluorescence in situ hybridization in breast fine-needle aspiration specimens from women at high risk for breast cancer

Omega-3 and Omega-6 Fatty Acids in Blood and Breast Tissue of High-Risk Women and Association with Atypical Cytomorphology

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

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