Short-Term Bone Responses to Hydroxyapatite Cement

Morio, Dominic; Lew, Daniel; Krizan, K. E.; Keller, John C.

doi:10.1097/00008505-200211040-00018

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…CMC and HPMC are considered suitable carriers based on evidence that both substances support the osteoinductive capacities of BMP‐25, 21–27 and BMP‐7,6–10, 28 as well as the osteoconductive properties of bone substitutes 29. However, whether CMC or HPMC can control the formation or the activity of osteoclasts and osteoblasts is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…CMC also serves as a carrier for bone substitutes such as calcium sulfate6 and a modified bovine‐derived hydroxyapatite matrix 7, 8. HPMC and chemical modifications thereof have been used as carriers for bone substitutes9 and bone cements 10. Thus, CMC and HPMC come into direct contact with cells that are involved in the process of bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Effects of carboxymethylcellulose and hydroxypropylmethylcellulose on the differentiation and activity of osteoclasts and osteoblasts

Agis

Beirer

Watzek

et al. 2010

J Biomedical Materials Res

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Carboxymethylcellulose (CMC) and hydroxypropylmethylcellulose (HPMC) serve as carriers for growth factors and bone substitutes. Although both carriers are placed into the defect sites, their impacts on bone regeneration are unclear. Herein, we examined whether CMC and HPMC affect the differentiation of bone marrow progenitors into osteoclasts and osteoblasts. We therefore induced osteoclastogenesis and osteoblastogenesis in murine bone marrow progenitors in the presence of CMC and HPMC, respectively. Measures of osteoclastogesis were based on the number and activity of tartrate-resistant acid-phosphatase-positive (TRAP(+)) multinucleated cells and expression of marker genes. Osteoblastogenesis was determined by the number and activity of alkaline-phosphatase-positive (AP(+)) colonies and relevant marker genes. Viability was assessed by colorimetric measurement of formazan formation. We report that CMC at 1% caused a significant reduction in the number and activity of TRAP(+) multinucleated cells. Changes in viability were not responsible for the observed effects. HPMC showed no remarkable impact on osteoclastogenesis; however, the concentration was limited to 0.5% because of the high viscosity. The ability of bone marrow progenitors to form AP(+) colonies was not affected by either of the two carriers. Together, these results suggest that CMC and possibly also HPMC can decrease osteoclastogenesis while osteoblastogenesis remains unchanged in vitro. These observations raise the possibility that these carriers might affect the cellular process of bone regeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of carboxymethylcellulose and hydroxypropylmethylcellulose on the differentiation and activity of osteoclasts and osteoblasts

Agis

Beirer

Watzek

et al. 2010

J Biomedical Materials Res

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“…In an experimental study, CPC was shown to be prone to in situ physical and chemical breakdown (washout phenomenon) before completion of the setting reaction [19,25,26]. In the present series, post-operative radiography sometimes showed insufficient filling of CPC due to the washout phenomenon when the operation was performed without a tourniquet.…”

Section: Discussionmentioning

confidence: 47%

Calcium phosphate cement in musculoskeletal tumor surgery

Matsumine

Kusuzaki

Matsubara

et al. 2006

Journal of Surgical Oncology

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“…The presence of EBPADMA can reduce the water absorption of the material (22) and, consequently, decrease the sealer solubility (1). With another solvent, Morio et al (23) verified that the hydroxypropylmethyl cellulose added to the hydroxyapatite cement formulations improved the physical properties of the material without compromising the biological characteristics of the cement. Pereira et al (24) observed that the triethylene glycol dimethacrylate diluent created a less viscous composite, favored the flexural strength and microhardness, and did not affect the module of elasticity of the material.…”

Section: Discussionmentioning

confidence: 99%