Short-term biological variation of serum thyroid hormones concentrations in clinically healthy cats

Prieto, Jennifer M.; Carney, Patrick C.; Miller, Meredith L.; Rishniw, Mark; Randolph, John F.; Lamb, Simon; Place, Ned J.; Peterson, Mark E.

doi:10.1016/j.domaniend.2019.106389

Cited by 12 publications

(59 citation statements)

References 48 publications

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“…It has recently been shown that, while healthy cats can have wide inter‐individual biological variation in serum TSH concentrations, most maintain serum TSH in the lower third of the population‐based reference interval (<0.1 ng/mL) (Prieto et al . 2020). While serum TSH was suppressed into the reference range in our cases, in only one of the six cats was it suppressed to the lowest third of the reference interval.…”

Section: Discussionmentioning

confidence: 99%

Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital

Iturriaga

Cocio

Barrs

2020

J of Small Animal Practice

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To describe the clinicopathological findings and outcomes of cases of feline congenital hypothyroidism diagnosed in a single veterinary hospital in Santiago, Chile. Materials and MethOds: Medical records were searched for cases of congenital hypothyroidism over an 18-month period. Inclusion criteria were a diagnosis of congenital hypothyroidism based on consistent historical and clinical findings, a low or low-normal serum total T4 and elevated serum canine TSH (cTSH). results: Six unrelated cats ranging in age from 4 to 19 months met the inclusion criteria. The most common historical signs were small stature and lethargy. All cats had disproportionate dwarfism, delayed tooth eruption, retained deciduous teeth, bilateral palpable goitres and low rectal temperatures. Other findings were bradycardia, obesity, poor hair coat and focal alopecia on the ventral aspects of the elbows and hocks. In all cases, cTSH was markedly elevated. Sequential changes noted after the initiation of therapy included normal T4 after 6 weeks, improved hair coat and increased physical activity by 8 weeks, normal cTSH by 10 weeks and normal physical appearance and dentition after 4 months. Goitres shrank markedly but remained palpable. Hypothyroidism was well managed clinically in all cases 2 years after diagnosis except for one cat that died of unrelated causes. clinical significance: This is the first report to describe a cluster of congenital hypothyroidism cases in non-related cats that were presented over a short period of time. Growth defects resolve with treatment, even in cats diagnosed after puberty. Larger, prospective multi-centre studies are warranted to determine the incidence of congenital hypothyroidism in cats.

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Section: Discussionmentioning

confidence: 99%

Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital

Iturriaga

Cocio

Barrs

2020

J of Small Animal Practice

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“…Box and whisker plots were constructed (GraphPad Prism 9.0.0; Gra-phPad Software, La Jolla, California) for each toxin in part 1 (short- Because the analysis was done on the log transformed scale, the (back transformed) coefficients of variation (CV) were calculated, as previously described, 19,20 using the equation:…”

Section: Discussionmentioning

confidence: 99%

“…RCVs were calculated using the lognormal approach, as previously described. 19,20 Specifically: Table 2. The RCVs for serum IS, pCS, and TMAO concentrations are reported in Table 3.…”

Section: Discussionmentioning

confidence: 99%

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Biological variation of major gut‐derived uremic toxins in the serum of healthy adult cats

Summers

Quimby

Yao

et al. 2021

Veterinary Internal Medicne

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Background: Biological variation of serum indoxyl sulfate (IS), p-cresol sulfate (pCS), and trimethylamine-n-oxide (TMAO) concentrations in cats is unknown. Objectives: To determine short-and medium-term biological variation, index of individuality (II), and reference change values for serum IS, pCS, and TMAO concentrations in healthy adult cats. To determine the effect of feeding on serum concentrations. Animals: Twelve healthy adult cats. Methods: Prospective, cohort study. Seven serum samples over a 12-hour period (short-term) and 5 serum samples over a 19-day period (medium-term) were collected. Serum concentrations of total IS, pCS, and TMAO were measured every 2 hours in a 12-hour period (hours 0-12) after a meal in 9 cats and compared to concentrations in a nonfed state. Results: For IS, the II was high using short-term (1.96) and low using medium-term (0.65) biological variation estimates. Individuality was intermediate for pCS (shortterm, 0.98; medium-term, 1.17) and TMAO (short-term, 1.47; medium-term, 0.83).

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“…Feline SDMA has previously been measured from sera frozen for longer than a year, 14 and canine SDMA has been shown to be stable after three freeze‐thaw cycles 12 . Fewer samples were available to measure SDMA by EMIT and creatinine because the same samples were used in multiple studies 15 . Hemolysis and lipemia indices, reported for all samples, were below levels causing any significant effects on analyte values.…”

Section: Methodsmentioning

confidence: 99%

Biologic variation of symmetric dimethylarginine and creatinine in clinically healthy cats

Prieto

Carney

Miller

et al. 2020

Veterinary Clinical Pathol

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Background: Biologic variation of biochemical analytes, both within individuals and between individuals, determines whether population-based reference intervals (RIs) are appropriate when interpreting if a particular change is clinically relevant for a specific individual. Objectives: We aimed to evaluate the biologic variation of symmetric dimethylarginine (SDMA) in clinically healthy cats. Methods: A prospective, observational study was performed in which 10 clinically healthy, client-owned cats were sampled for serum biochemical analyses once weekly for 6 weeks. Serum samples were frozen, and then single batches were analyzed for SDMA, using both liquid chromatography-mass spectroscopy (LC-MS), and an enzyme multiplied immunoassay technique (EMIT), and creatinine by modified Jaffe method. Restricted maximum likelihood estimations were used to determine the coefficients of variation (CVs) describing variation within each cat, between cats, and the analytical variation. These CVs were used to determine the indices of individuality and reference change values (RCVs). Results: SDMA had an intermediate index of individuality that could be evaluated by both RCV and population-based RIs. In contrast, creatinine had a high index of individuality best evaluated with RCVs. Serum SDMA concentrations evaluated with either the reference standard, LC-MS, or the clinically used EMIT yielded similar results. Conclusions: Clinicians should consider biologic variation when selecting the best method for interpreting changes in biochemical analytes. Specifically, establishing each cat's baseline serum creatinine and SDMA concentrations during health, and applying RCVs to subsequent measurements could improve the recognition of meaningful biologic changes.

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Short-term biological variation of serum thyroid hormones concentrations in clinically healthy cats

Cited by 12 publications

References 48 publications

Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital

Cluster of cases of congenital feline goitrous hypothyroidism in a single hospital

Biological variation of major gut‐derived uremic toxins in the serum of healthy adult cats

Biologic variation of symmetric dimethylarginine and creatinine in clinically healthy cats

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