Short term association between air pollution (PM10, NO2 and O3) and secondary spontaneous pneumothorax

Abstract

Secondary spontaneous pneumothorax (SSp) occurs in the context of underlying pulmonary disease. our objectives were to estimate the relationship between SSp and short term air pollution exposure with nitrogen dioxide (no 2), ozone (o 3) and particulate matter with a diameter ≤ 10 μm (pM 10). Patients with SSP were included between June 1, 2009 and May 31, 2013, in 14 Emergency Departments in france. in this case-crossover design study, pM 10, no 2 , and o 3 data were collected hourly from monitoring stations. Quantitative values, fast increase in air pollutant concentration, and air quality threshold exceedance were retained. these assessments were calculated for each of the 4 days prior to the event (Lag 1-Lag 4) for all case and control period, and for the entire exposure period. A total of 135 patients with SSP were included, with a mean age of 55.56 (SD 18.54) years. for short term exposure of pM 10 , no 2 and o 3 , no differences were observed between case and control periods in terms of quantitative values of air pollutant exposure (P > 0.68), fast increase in concentration (P > 0.12) or air quality threshold exceedance (P > 0.68). An association between O 3 exposures cannot be ruled out, especially when considering the Lag 2 prior to the event and in warm seasons.

Air Pollution Exposure and Risk of Spontaneous Pneumothorax in Children: A Longitudinal, Nationwide Study

“…Several previous studies have indicated that exposure to air pollutants such as NO 2 , PM and O 3 might induce systemic inflammation [ 11 , 12 ]. Air pollutants such as NO and hydrocarbon may enter the pleural space through various mechanisms: direct alveolar rupture (as in emphysema or necrotic pneumonia) via the lung interstitium or backward via the bronchovascular bundle and mediastinal pleura (pneumomediastinum).…”

“…Some studies have suggested that atmospheric pressure, temperature changes, and specific weather phases may be precipitating factors in the development of SP [ 9 , 10 ]. Han et al found that air pollution exposure, especially pollution containing particulate matter (PM), increased hospital visits due to SP [ 11 ]; however, a recent study by Marx et al found no connection between exposure to NO 2 or PM with diameters ≤10 µm (PM 10 ) and primary SP but did identify an association between SP and O 3 exposure [ 12 ]. In summary, the association between air pollution and SP remains unclear and debatable.…”

Air pollution and hospital admissions for critical illness in emergency department: a tertiary-center research in Changsha, China, 2016–2020

“…However, some studies showed the opposite conclusions on the association between air pollution and some diseases. A research from France illuminated that there was no significant difference between spontaneous pneumothorax and short-term exposure of air pollutants, which included PM 10 , NO 2 , and O 3 (Marx et al 2020). Another research from Israel with 641 conjunctivitis patients found that no significant association was observed between conjunctivitis and air pollution (Khalaila et al 2021).…”