Short-term and residential exposure to air pollution: Associations with inflammatory biomarker levels in adults living in northern France

Darras-Hostens, Marion; Achour, Djamal; Muntaner, Manon; Grare, Céline; Zarcone, Gianni; Garçon, Guillaume; Amouyel, Philippe; Zerimech, Farid; Matran, Régis; Guidice, Jean‐Marc Lo; Dauchet, Luc

doi:10.1016/j.scitotenv.2022.154985

Cited by 6 publications

(5 citation statements)

References 70 publications

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“…Hs-CRP is the specific biomarker of low but persistent levels of inflammation [20]. A previous study has demonstrated that short-term exposure to either PM 2.5 or Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Hs-CRP is the specific biomarker of low but persistent levels of inflammation [ 20 ]. A previous study has demonstrated that short-term exposure to either PM 2.5 or PM 10 raised hs-CRP levels, with PM 2.5 having a larger effect than PM 10 [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus far, the association of short-term air pollution exposure with NLR has been less characterized, with no evidence available for rural populations. In addition, high-sensitivity C-reactive protein (hs-CRP), a simple, rapid and cost-effective biomarker of systemic inflammation [18], has been widely utilized to assess health effects of short-term air pollution exposure due to its high sensitivity, but the existing evidence appears inconsistent [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents

Yang,

Wu,

Zeng

et al. 2024

BMC Public Health

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Effects of short-term exposure to ambient air pollution on systemic immunological and inflammatory biomarkers in rural population have not been adequately characterized. From May to July 2021, 5816 participants in rural villages of northern Henan Province, China, participated in this cross-sectional study. Blood biomarkers of systemic inflammation were determined including peripheral white blood cells (WBC), eosinophils (EOS), basophils (BAS), monocytes (MON), lymphocytes (LYM), neutrophils (NEU), neutrophil-lymphocyte ratio (NLR), and serum high-sensitivity C-reactive protein (hs-CRP). The concentrations of ambient fine particulate matter (PM2.5), PM10, nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3) were assessed up to 7 days prior to the blood draw. A generalized linear model was used to analyze the associations between air pollution exposure and the above-mentioned blood biomarkers. Significantly positive associations were revealed between PM2.5, CO and WBC; CO, O3 and LYM; PM2.5, PM10, SO2, CO and NEU; PM2.5, PM10, SO2, CO and NLR; PM2.5, PM10, SO2, NO2, CO, O3 and hs-CRP. Meanwhile, negative associations were found between SO2 and WBC; PM2.5, PM10, NO2, CO, or O3 and EOS; PM2.5, SO2, or CO and BAS; SO2, NO2 or O3 and MON; PM2.5, PM10, SO2, or NO2 and LYM. Moreover, men, individuals with normal body mass index (BMI), current smokers, and those older than 60 years were found vulnerable to air pollution effects. Taken together, short-term exposure to air pollution was associated with systemic inflammatory responses, providing insight into the potential mechanisms for air pollution-induced detrimental systemic effects in rural residents.

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“…Hs-CRP is the specific biomarker of low but persistent levels of inflammation [20]. A previous study has demonstrated that short-term exposure to either PM 2.5 or Fig.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents

Yang,

Wu,

Zeng

et al. 2024

BMC Public Health

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“…Prolonged exposure to environmental factors, such as carcinogenic air pollutants, is frequently associated with the initiation of low-grade inflammation. For example, Darras et al (2022), evaluating 3074 individuals, revealed that short-term exposure to air pollution is linked to elevated serum levels of high-sensitivity C-reactive protein (hsCRP) in adult residents of urban areas [ 33 ]. On the other hand, Kim et al (2020) delved into the effects of long-term exposure to ambient air pollution on high-sensitivity, low-grade inflammation in 60,581 participants.…”

Section: Air Pollution and The Development Of Lung Cancer: Potential ...mentioning

confidence: 99%

Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility

González-Ruíz,

A.Baccarelli,

Cantu-de-Leon

et al. 2023

Curr Envir Health Rpt

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Purpose of Review This review addresses the pressing issue of air pollution’s threat to human health, focusing on its connection to non-small cell lung cancer (NSCLC) development. The aim is to explore the role of extracellular vesicles (EVs) as potential pathogenic mechanisms in lung cancer, including NSCLC, induced by air pollutants. Recent Findings Recent research highlights EVs as vital mediators of intercellular communication and key contributors to cancer progression. Notably, this review emphasizes the cargo of EVs released by both cancerous and non-cancerous lung cells, shedding light on their potential role in promoting various aspects of tumor development. Summary The review underscores the importance of comprehending the intricate interplay between air pollution, biological damage mechanisms, and EV-mediated communication during NSCLC development. Major takeaways emphasize the significance of this understanding in addressing air pollution-related lung cancer. Future research avenues are also highlighted, aiming to enhance the applicability of EVs for diagnosis and targeted therapies, ultimately mitigating the inevitable impact of air pollution on NSCLC development and treatment.

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“…Maternal health and environment during pregnancy play a crucial role in the early life neurodevelopment of offspring, and systemic inflammation in the mothers has been shown to be among the most important risk factors [ 1 ]. Such inflammation may be the result of bacterial or viral infections and environmental exposures [ 2 , 3 ], but can also be due to certain medical conditions of pregnancy including preeclampsia and elevated body mass index, or to other prenatal stressors; both common daily stressors and more extreme levels of stress during pregnancy have been associated with adverse neurodevelopment in the children [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal Inflammatory Biomarkers during Pregnancy and Early Life Neurodevelopment in Offspring: Results from the VDAART Study

Kelly

Lee-Sarwar

Chen

et al. 2022

IJMS

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Maternal infection and stress during the prenatal period have been associated with adverse neurodevelopmental outcomes in offspring, suggesting that biomarkers of increased inflammation in the mothers may associate with poorer developmental outcomes. In 491 mother–child pairs from the Vitamin D Antenatal Asthma Reduction Trial (VDAART), we investigated the association between maternal levels of two inflammatory biomarkers; interleukin-8 (IL-8) and C-Reactive Protein (CRP) during early (10–18 wks) and late (32–38 wks) pregnancy with offspring scores in the five domains of the Ages and Stages Questionnaire, a validated screening tool for assessing early life development. We identified a robust association between early pregnancy IL-8 levels and decreased fine-motor (β: −0.919, 95%CI: −1.425, −0.414, p = 3.9 × 10−4) and problem-solving skills at age two (β: −1.221, 95%CI: −1.904, −0.414, p = 4.9 × 10−4). Associations between IL-8 with other domains of development and those for CRP did not survive correction for multiple testing. Similarly, while there was some evidence that the detrimental effects of early pregnancy IL-8 were strongest in boys and in those who were not breastfed, these interactions were not robust to correction for multiple testing. However, further research is required to determine if other maternal inflammatory biomarkers associate with offspring neurodevelopment and work should continue to focus on the management of factors leading to increases in IL-8 levels in pregnant women.

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Short-term and residential exposure to air pollution: Associations with inflammatory biomarker levels in adults living in northern France

Cited by 6 publications

References 70 publications

Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents

Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents

Air Pollution and Lung Cancer: Contributions of Extracellular Vesicles as Pathogenic Mechanisms and Clinical Utility

Maternal Inflammatory Biomarkers during Pregnancy and Early Life Neurodevelopment in Offspring: Results from the VDAART Study

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