Short-term and long-term monitoring of the serum level of TPA after radical resection of gastrointestinal or lung cancer

Cytokeratin 8: The Dominant Type II Intermediate Filament Protein in Lung Cancer

“…Temporal elevations of TPA after surgery for gastric cancer or lung cancer were attributable to tissue repair and physiological cell proliferation as described previously in this chapter (Bauer et al, 1986). Increased serum levels of Cyfra 21-1 were observed in patients with diffuse radiation pneumonitis (inflammation in non-tumorous lung tissues caused by chest radiation therapy), suggesting inflamed lung epithelial tissues as non-cancerous source of circulating CKs (Fujita et al, 2004).…”

“…CKs have been found in extracellular spaces both in vitro and in vivo, in conditioned culture medium to circulating human blood. CK release is observed during cell growth/cell divisions, after surgical intervention, and upon cell death induction (e.g., radiation therapy and/or cytotoxic chemotherapy) (Bauer et al, 1986;Bjorklund & Bjorklund, 1983;Brabon et al, 1984;Caulin et al, 1997;Dohmoto et al, 2000;Dohmoto et al, 2001;Sheard et al, 2002;Tinnemans et al, 1995).…”

“…Serum levels of TPA immediately fell after surgery, and following the initial 2 weeks after complete removal of tumors, serum TPA rise to some extent. This temporal increment is interpreted as being caused by tissue repair and cell proliferation (Bauer et al, 1986).…”

Elevated Tissue Polypeptide Antigen as a Risk Factor for Carpal Tunnel Syndrome in Haemodialyzed Patients

“…While TPA is routinely used for the monitoring o f malig nancies, it is also known to be elevated during periods of increased cell proliferation [10]. The individual extent of cell turnover caused by the extracorporeal circuit may be estimated by TPA serum cencentrations and could thus be an index for the susceptibility o f CTS in patients on long-term HD.…”