2006
DOI: 10.1016/j.ejcts.2005.10.001
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Short-term and long-term cognitive function and cerebral perfusion in off-pump and on-pump coronary artery bypass patients

Abstract: The coronary revascularization on beating heart or preventive administration of instenon in CPB patients helps significantly to diminish the risk of cerebrovascular complication.

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Cited by 42 publications
(26 citation statements)
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“…Of the 10 authors contacted, seven replied and two were able to forward further data to enable inclusion in the meta-analysis [25,31]. Of the 24 studies initially identified for possible inclusion in the meta-analysis, 16 were rejected and are listed in Table 1 [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. The primary endpoints in those trials and the reasons for exclusion are also listed.…”
Section: Resultsmentioning
confidence: 99%
“…Of the 10 authors contacted, seven replied and two were able to forward further data to enable inclusion in the meta-analysis [25,31]. Of the 24 studies initially identified for possible inclusion in the meta-analysis, 16 were rejected and are listed in Table 1 [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. The primary endpoints in those trials and the reasons for exclusion are also listed.…”
Section: Resultsmentioning
confidence: 99%
“…Neurologic dysfunctions are related to on-pump CABG [8,14], especially with a prolonged CPB time [15]. Because of its adverse effects, alternatives that could diminish the morbidity of CPB have been investigated.…”
Section: Resultsmentioning
confidence: 99%
“…They maintain appropriate hemodynamic support and control the temperature of patient. However, especially after an extended period of time time, the CPB, causes metabolic changes [4], endocrine responses [5], inflammatory responses [6], reduction of the number and function of platelets [7] and cognitive changes [8].…”
Section: Introductionmentioning
confidence: 99%
“…Millions of emboli in the cerebral arterioles were found in the brains of 22 autopsies that died after CPB, whereas in brains of control with hypertension or leukoaraiosis or Alzheimer's disease with no history of open-heart surgery, the emboli were absent (15). Adverse effects of CPB could result in cerebral injury as evidenced by the decrease in regional cerebral blood flow and improvement of cerebral perfusion 6 months after coronary artery bypass (16). During hypothermic CPB with α-stat management of PaCO 2 , cerebral pressure autoregulation is well maintained.…”
Section: Discussionmentioning
confidence: 99%
“…Release of S100 protein showed higher values in patients undergoing standard CPB than after minimal extracorporeal circulation (19). Prolonged mechanical ventilation and increased the number of bypassed coronary arteries also contributed to impaired verbal memory and deteriorated cerebral blood perfusion (16). Perioperative cerebral impairment can be reduced in cardiac operations without the use of CPB, for example, in offpump coronary artery bypass (20).…”
Section: Discussionmentioning
confidence: 99%