Short-term administration of omega-3 fatty acids in hemodialysis patients with balanced lipid metabolism

Fiedler, Roman; Mall, Margit; Wand, Clemens; Osten, B

doi:10.1053/j.jrn.2005.01.007

Cited by 36 publications

(32 citation statements)

References 29 publications

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“…The authors supposed that only high doses of omega-3 fatty acids given for a longer period had influenced inflammation and atherosclerosis. [30] A significant increase in EPA and DHA as well as a significant decrease of SFAs percentage in membrane phospholipids was registered in our HD patients after the eight weeks of supplementation. Also, a significant increase in total n-3 PUFAs and n-6 PUFAs was noted.…”

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confidence: 52%

Effects of N-3 PUFAs Supplementation on Insulin Resistance and Inflammatory Biomarkers in Hemodialysis Patients

et al. 2007

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Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 ± 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementation (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (p = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (p = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both).There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 18% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented.

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confidence: 52%

Effects of N-3 PUFAs Supplementation on Insulin Resistance and Inflammatory Biomarkers in Hemodialysis Patients

et al. 2007

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“…Lastly, a clear relationship between the degree of decrease in LTB 4 concentration and improved pruritus symptoms was not established. A short-term, prospective and uncontrolled pilot study by Fiedler et al 16 investigated the effects of omega-3 fatty acid supplementation on serum concentrations of C-reactive protein (CRP), homocysteine, lipoproteins, complement factors, blood gas, peripheral oxygen saturation, blood pressure, heart rate variability, electrocardiography, shunt blood flow and recirculation, and itching symptoms in HD patients. Eleven non-diabetic HD patients with balanced lipid metabolism were treated with 1.2 g omega-3 fatty acids combined with 11.2 g pectin per day for 12 weeks.…”

Section: Omega-3 On Ckd-associated Pruritusmentioning

confidence: 99%

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Panahi¹,

Dashti‐Khavidaki²,

Farnood³

et al. 2016

Adv Pharm Bull

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“…18) Previous studies have examined the influence of n-3 PUFAs on autonomic activity analyzed by the power spectral and time-domain methods. [19][20][21][22][23] Some studies showed a positive association between n-3 PUFAs and HRV in patients with ischemic heart disease 19) and, in those with dilated cardiomyopathy 20) as well as in healthy subjects. 21) In contrast, no changes in HRV parameters were observed in some studies conducted among healthy subjects and haemodialysis patients.…”

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confidence: 99%

Association of Serum n-3/n-6 Polyunsaturated Fatty Acid Ratio With T-Wave Alternans in Patients With Ischemic Heart Disease

et al. 2015

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SummarySeveral studies have demonstrated that oral intake of n-3 polyunsaturated fatty acids, specifically eicosapentaenoic acid (EPA), prevents ventricular tachyarrhythmias (VT) with ischemic heart disease, but the underlying mechanisms still remain unclear. Thus, we examined the relation between the serum EPA/arachidonic acid (AA) ratio and electrophysiological properties in patients with ischemic heart disease. The study subjects consisted of 57 patients (46 males, mean age, 66 ± 13 years) with ischemic heart disease. T-wave alternans (TWA) and heart rate variability were assessed by 24-hour Holter ECG, and left ventricular ejection fraction (LVEF) was determined by echocardiography. Fasting blood samples were collected, and the serum EPA/AA ratio was determined. Based on a median value of the serum EPA/AA ratio, all subjects were divided into two groups: serum EPA/AA ratio below 0.33 (Group-L, n = 28) or not (Group-H, n = 29). We compared these parameters between the two groups. LVEF was not different between the two groups. The maximum value of TWA was significantly higher in Group-L than in Group-H (69.5 ± 22.8 μV versus 48.7 ± 12.0 μV, P = 0.007). In addition, VT defined as above 3 beats was observed in 7 cases (25%) in Group-L, but there were no cases of VT in Group-H (P = 0.004). However, low-frequency (LF) component, high-frequency (HF) component, LF to HF ratio, and standard deviation of all R-R intervals were not different between the two groups. These results suggest that a low EPA/AA ratio may induce cardiac electrical instability, but not autonomic nervous imbalance, associated with VT in patients with ischemic heart disease. (Int Heart J 2015; 56: 613-617)

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Short-term administration of omega-3 fatty acids in hemodialysis patients with balanced lipid metabolism

Cited by 36 publications

References 29 publications

Effects of N-3 PUFAs Supplementation on Insulin Resistance and Inflammatory Biomarkers in Hemodialysis Patients

Effects of N-3 PUFAs Supplementation on Insulin Resistance and Inflammatory Biomarkers in Hemodialysis Patients

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Association of Serum n-3/n-6 Polyunsaturated Fatty Acid Ratio With T-Wave Alternans in Patients With Ischemic Heart Disease

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