Short-stranded DNA segment-modulated LAMP/H+ as signal transducer to guide CHA-cooperated amplifiable electrochemical biosensing

Magnetic composite microspheres with a controlled mesoporous shell for highly efficient DNA extraction and fragment screening

“…In the past few decades, it has been discovered that highly fragmented small-sized DNA in blood is important for non-invasive prenatal diagnosis, early diagnosis, and cancer monitoring. 40–43 Generally, gel electrophoresis is the conventional method used for the selective separation of DNA with different fragment lengths, 44–46 which can separate diverse sizes of DNA fragments according to their charges. However, this method is time-consuming and increases the possibility of DNA fragmentation or even a loss of target DNA.…”