Short review: The impact of sex on neuroimmune and cognitive outcomes after traumatic brain injury

Krukowski, Karen

doi:10.1016/j.bbih.2021.100327

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…Here we demonstrate robust blast-induced changes in serum and brain cytokine levels that display similar and disparate patterns in male vs. female mice. In line with these results, models of single moderate to severe impact TBI have demonstrated disparate inflammatory outcomes in male vs. female mice acutely following injury (Bromberg et al, 2020;Doran et al, 2019;Krukowski, 2021;Krukowski et al, 2020;Späni et al, 2018;Villapol et al, 2017). Likewise, a recent study using a single mild blast exposure with body shielding reported worse acute and sub-acute neuroinflammatory and BBB outcomes in male vs. female rats (Hubbard et al, 2022).…”

Section: Discussionmentioning

confidence: 82%

Timing matters: Sex differences in acute and chronic outcomes following repetitive blast mild traumatic brain injury

Baskin

Logsdon

Lee

et al. 2022

Preprint

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Background: Repetitive blast-related mild traumatic brain injury (mTBI) caused by exposure to high explosives is increasingly common among warfighters as well as civilians. While women have been serving in military positions with increased risk of blast exposure since 2016, there are few published reports examining sex as a biological variable in models of blast mTBI, greatly limiting diagnosis and treatment capabilities. As such, here we examined acute and chronic outcomes of repetitive blast trauma in female and male mice in relation to potential behavioral, inflammatory, microbiome, and vascular dysfunction. Methods: In this study we utilized a well-established blast overpressure model to induce repetitive (3x) blast-mTBI in both female and male mice. Acutely following repetitive exposure, we measured serum and brain cytokine levels, blood-brain barrier (BBB) disruption, fecal microbial abundance, and locomotion and anxiety-like behavior in the open field assay. Chronically, in female and male mice we assessed behavioral correlates of mTBI and PTSD-related symptoms commonly reported by Veterans with a history of blast-mTBI using the elevated zero maze, acoustic startle, and conditioned odorant aversion paradigms. Results: Repetitive blast exposure resulted in similar and disparate patterns of acute serum and brain cytokine as well as gut microbiome changes in female and male mice. Acute BBB disruption following repetitive blast exposure was apparent in both sexes. While female and male blast mice both exhibited acute locomotor and anxiety-like deficits in the open field assay, only male mice exhibited chronic adverse behavioral outcomes. Discussion: Representing a novel survey of potential sex differences following repetitive blast trauma, our results demonstrate unique similar and divergent patterns of blast-induced dysfunction in female vs. male mice and highlight novel targets for future diagnosis and therapeutic development.

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Section: Discussionmentioning

confidence: 82%

Timing matters: Sex differences in acute and chronic outcomes following repetitive blast mild traumatic brain injury

Baskin

Logsdon

Lee

et al. 2022

Preprint

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“…More recently, mTBI effects and long-term sequelae are being extensively studied, such as noise sensitivity [12], insomnia [13], cognitive impairment [14], visual field defects [15], changes in White Matter (WM) Fractional Anisotropy (FA) [16], among many others. However, most of these studies regarding mTBI lack sex-specific data, even though distinct effects on women and men are often reported in the literature [17,18].…”

Section: Introductionmentioning

confidence: 99%

Biomechanics of Traumatic Head and Neck Injuries on Women: A State-of-the-Art Review and Future Directions

Carmo

Grigioni²,

Fernandes³

et al. 2023

Biology

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The biomechanics of traumatic injuries of the human body as a consequence of road crashes, falling, contact sports, and military environments have been studied for decades. In particular, traumatic brain injury (TBI), the so-called “silent epidemic”, is the traumatic insult responsible for the greatest percentage of death and disability, justifying the relevance of this research topic. Despite its great importance, only recently have research groups started to seriously consider the sex differences regarding the morphology and physiology of women, which differs from men and may result in a specific outcome for a given traumatic event. This work aims to provide a summary of the contributions given in this field so far, from clinical reports to numerical models, covering not only the direct injuries from inertial loading scenarios but also the role sex plays in the conditions that precede an accident, and post-traumatic events, with an emphasis on neuroendocrine dysfunctions and chronic traumatic encephalopathy. A review on finite element head models and finite element neck models for the study of specific traumatic events is also performed, discussing whether sex was a factor in validating them. Based on the information collected, improvement perspectives and future directions are discussed.

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“… Krukowski (2021) summarizes evidence for sex differences in models for traumatic brain injury (TBI) and space radiation. Overall, it is revealed that neuroimmune alterations, like microglial responses, appear to be more severe in male than female animals or even absent in females exposed to space radiation.…”

Section: Introductionmentioning

confidence: 99%

Editorial commentary on the special issue emerging psychoneuroimmunology research: Future leaders in focus

Kentner

Harden

Soares

et al. 2022

Brain, Behavior, & Immunity - Health

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The theme of this BBI-Health special issue is to promote the research, creativity and forward-thinking of future key opinion leaders in the field of psychoneuroimmunology (PNI). We asked contributing researchers to identify new ideas and spaces for innovation to map out the future trajectory of our discipline. This special issue provides global and diverse views from early career investigators focused on science, society, and/or policy, with an emphasis on diversity in all its aspects. The common thread weaving through the articles contained in this special issue is that all authors were invited to consider the future of PNI while they were experiencing the global COVID-19 lockdowns that slowed down or even prevented them from access to their “hands-on” research. The contributors vary from Master level to assistant professors, and all have already significantly contributed to the field of PNI. Each contributor has provided a photograph and short biography alongside their written perspectives. We hope that you will enjoy learning about their visions for the future of PNI and will join us with enthusiasm as we watch our field grow through the advancement of their scientific careers.

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Short review: The impact of sex on neuroimmune and cognitive outcomes after traumatic brain injury

Cited by 6 publications

References 45 publications

Timing matters: Sex differences in acute and chronic outcomes following repetitive blast mild traumatic brain injury

Timing matters: Sex differences in acute and chronic outcomes following repetitive blast mild traumatic brain injury

Biomechanics of Traumatic Head and Neck Injuries on Women: A State-of-the-Art Review and Future Directions

Editorial commentary on the special issue emerging psychoneuroimmunology research: Future leaders in focus

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