Short Review of Calcium Disodium Ethylene Diamine Tetra Acetic Acid as a Food Additive

Sande, M.M. van De; Wirtz, Sabrina; Vos, Ellen; Verhagen, Hans

doi:10.9734/ejnfs/2014/10405

Cited by 5 publications

(2 citation statements)

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“…Chemical features of this agent make it suitable for intraocular administration. It is metabolically inert and does not accumulate in the eye [24] . It is water soluble with a pH of 8.0, and is therefore in the safe range for intraocular tissues.…”

Section: Introductionmentioning

confidence: 99%

Ocular safety of intravitreal ethylene diamine tetra acetic acid (EDTA): An experimental feasibility study

Zand¹,

Falavarjani²,

Kanavi³

et al. 2023

Toxicology Reports

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Section: Introductionmentioning

confidence: 99%

Ocular safety of intravitreal ethylene diamine tetra acetic acid (EDTA): An experimental feasibility study

Zand¹,

Falavarjani²,

Kanavi³

et al. 2023

Toxicology Reports

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“…[M-EDTA] complexes have been extensively utilized for various applications such as analytical titrations 14 , biological catalysts 15 , waste treatments 16,17 , chelation therapy 18 and additives in the food industry 19 . However, these complexes, particularly paramagnetic, have not been investigated…”

Section: Introductionmentioning

confidence: 99%

NMR-Responsive Paramagnetic [M-EDTA] (M = Fe³⁺, Mn²⁺, Cu²⁺) Complexes to Differentiate T₂-Distribution Signals of Crude Oil and Brine

et al. 2019

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Nuclear magnetic resonance (NMR) well logging tools are being commercially utilized for the characterization of various fluids confined within reservoir rocks. Conventional NMR T2distribution measurements are unable to quantify the actual fractions of crude oil and brine simultaneously present in the reservoir rocks. Herein, we reported NMR responsive paramagnetic [M-EDTA] (M = Fe 3+ , Mn 2+ , Cu 2+) complexes having the capability to differentiate NMR T2distribution signals coming from crude oil and brine by accelerating the water (1 H) relaxation. The formation of these [Fe-EDTA]-, [Mn-EDTA] 2and [Cu-EDTA] 2complexes was explored by UVvisible spectroscopy, and their chemical stability in brine solution was monitored by measuring the change in percent transmittance and backscattering intensities with time. Spin-spin (T2) relaxation signals and T2-distribution spectra of various carbonate and sand packs were recorded. The separation of NMR T2-distribution signals was achieved using the optimized concentration of synthesized paramagnetic complexes. The separation of NMR T2-distribution signals with optimum concentration of complexes and their long-term chemical stability in brine solution suggest them to be commercially reliable contrast agents for the characterization of various rock fluids confined in the oil reservoirs.

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Should DTPA, an Aminocarboxylic acid (ethylenediamine-based) chelating agent, be considered a developmental toxicant?

Arts

Bade

Badrinas³

et al. 2018

Regulatory Toxicology and Pharmacology

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Aminocarboxylic acid (ethylenediamine-based) chelating agents, such as DTPA and EDTA, are widely used in a variety of products and processes. Recently the European RAC proposed to classify DTPA as a developmental toxicant Category 1B according to CLP. This paper provides unequivocal and significant evidence that developmental effects cannot be considered an intrinsic property of the chelating substances themselves since: (1) animals fed a zinc deficient diet during gestation exhibit developmental toxicity of a similar nature and severity to that observed in studies involving such chelates, (2) sufficient supplementation of zinc in the diet, or administration of zinc bound chelates, completely negates the developmental effects. Moreover, the bioavailability of DTPA is very low with >95% of oral doses excreted unchanged via the feces within 24 h. If DTPA would possess the intrinsic property to be developmentally toxic, simple zinc supplementation should not be sufficient to negate these effects. Furthermore, the relevance of classification is highly questionable since worker or consumer exposure could not lead to a scenario whereby sufficient zinc deficiency would manifest itself. Therefore classification of DTPA for such effects is not protective of human health; instead it leads to onerous and disproportionate restrictions being placed on this substance.

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Short Review of Calcium Disodium Ethylene Diamine Tetra Acetic Acid as a Food Additive

Cited by 5 publications

References 0 publications

Ocular safety of intravitreal ethylene diamine tetra acetic acid (EDTA): An experimental feasibility study

Ocular safety of intravitreal ethylene diamine tetra acetic acid (EDTA): An experimental feasibility study

NMR-Responsive Paramagnetic [M-EDTA] (M = Fe³⁺, Mn²⁺, Cu²⁺) Complexes to Differentiate T₂-Distribution Signals of Crude Oil and Brine

Should DTPA, an Aminocarboxylic acid (ethylenediamine-based) chelating agent, be considered a developmental toxicant?

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Short Review of Calcium Disodium Ethylene Diamine Tetra Acetic Acid as a Food Additive

Cited by 5 publications

References 0 publications

Ocular safety of intravitreal ethylene diamine tetra acetic acid (EDTA): An experimental feasibility study

Ocular safety of intravitreal ethylene diamine tetra acetic acid (EDTA): An experimental feasibility study

NMR-Responsive Paramagnetic [M-EDTA] (M = Fe3+, Mn2+, Cu2+) Complexes to Differentiate T2-Distribution Signals of Crude Oil and Brine

Should DTPA, an Aminocarboxylic acid (ethylenediamine-based) chelating agent, be considered a developmental toxicant?

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Product

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NMR-Responsive Paramagnetic [M-EDTA] (M = Fe³⁺, Mn²⁺, Cu²⁺) Complexes to Differentiate T₂-Distribution Signals of Crude Oil and Brine