Short report: hematological outcomes in progression of malaria: a cohort study from district Dera Ismail Khan, Pakistan

Ullah, Zahid; Khattak, Aamer Ali; Aziz, Nighat; Shafi, Ruqqia; Khan, Hassan; Bano, Rahila; Awan, Usman Ayub

doi:10.5455/jpma.15845

Cited by 4 publications

(7 citation statements)

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“…Similarly, Khan (2014) concluded that P. vivax was common during August-October with a peak in October, whereas P. falciparum infection was most common during October-December with a peak in October in the district Bannu. Ullah et al (2020) found 366 (91.5%)…”

Section: Discussionmentioning

confidence: 98%

“…Nevertheless, mostly malaria in Pakistan is caused by P. vivax (Najera 2001;WHO, 2012;Ibrahim et al 2014;Majid et al 2016;Shah et al, 2016) and the country is endemic for both species of plasmodium (Asif, 2008;Yasinzai, 2008). Malaria is the second-highest disease, which affects about 4 million people annually in Pakistan (Ullah et al 2020).…”

Section: Introductionmentioning

confidence: 99%

“…While, PTB is caused by Mycobacterium tuberculosis, and is one of the deadliest diseases of lung globally (Khan 2020). PTB is transmitted through inhaling air containing droplets released by sneezing and coughing of an infected individual (WHO 2010;Ricks et al 2011;Khaliq et al 2015).…”

Section: Introductionmentioning

confidence: 99%

“…TB is one of the top 10 causes of death globally (WHO 2020;Li et al 2021). Pakistan ranked fth among 30 high-TB burden countries (Khaliq et al 2015, Khan 2017WHO 2018;Tahseen et al 2020) which covered 87% of the TB cases globally [Khan 2020;Qadeer et al 2016;Khan 2017). This is the rst study that deals with the seasonal and monthly prevalence of several major infectious diseases in the District Dera Ismail Khan including diarrhea/dysentery, typhoid/enteric, malaria, pneumonia, PTB, and EPTB.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of several infectious diseases in the District Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan

Khan¹

2022

Preprint

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Aims: Infectious disease is a health disorder and is the leading cause of morbidity and mortality in humans globally. The present study determined the prevalence of several highly infectious diseases in the District Dera Ismail Khan. Subject and Methods: The retrospective study include the indoor data from December 2019 through November 2021 (two years) were collected from the admin office of District Head Quarter Teaching Hospital, Dera Ismail Khan. Results: Overall diarrhea/dysentery showed the highest (59.1%) while pulmonary tuberculosis demonstrated the lowest prevalence (1.8%) and May contributed the largest share (16%), while February lowest (3.9%). Diarrhea/dysentery has relative the highest prevalence for most of the months. Overall diarrhea/dysentery, enteric/typhoid, and pneumonia contribute to 91.4% share of the studied diseases. The overall prevalence of the diseases increased steadily from March through May. Diarrhea/dysentery and malaria resulted in the highest prevalence of 19.6% and 17.1%, respectively in May, while enteric/typhoid revealed the highest prevalence of 24.4% in August. Pneumonia (23.5%) in June, Pulmonary tuberculosis (26.2%) in November, Extra Pulmonary tuberculosis in March (65.4%). Conclusion: Monthly and seasonal variations occurred in the prevalence of the diseases which is associated with an increase in vector population and an increase in temperature.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of several infectious diseases in the District Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan

Khan¹

2022

Preprint

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“…It is the second highest ranking reported disease in the public sectors in Pakistan 11 infecting 4 million people annually. 1 The struggle for a vaccine providing protection 12 against malaria finally was successful when WHO recommended widespread usage of 13 the newly developed RTS,S/AS01 (RTS,S) malaria vaccine for children at risk. The…”

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confidence: 99%

Will the malaria vaccine be accepted in Pakistan after the experience of Covid-19 experience?

et al. 2022

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Malaria, caused by Plasmodium species is transmitted by a female Anopheles mosquito. It is the second highest ranking reported disease in the public sectors in Pakistan infecting 4 million people annually.1 The struggle for a vaccine providing protection against malaria finally was successful when WHO recommended widespread usage of the newly developed RTS,S/AS01 (RTS,S) malaria vaccine for children at risk. The vaccine’s efficacy against all clinical episodes of malaria was 51% for children in the age range of 5–17 months after a year following the first 3 doses.2 ---Continue

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Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon

Villasis

Castillo

Guzmán

et al. 2022

Front. Cell. Infect. Microbiol.

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IntroductionHerein, we tested the hypothesis that Asymptomatic P. vivax (Pv) infected individuals (Asym) feature different epidemiological, clinical and biochemical characteristics, as well as hematological parameters, potentially predictive of clinical immunity in comparison to symptomatic Pv infected individuals (Sym).MethodologyBetween 2018 - 2021, we conducted 11 population screenings (PS, Day 0 (D0)) in 13 different riverine communities around Iquitos city, in the Peruvian Amazon, to identify Pv Sym and Asym individuals. A group of these individuals agreed to participate in a nested case - control study to evaluate biochemical and hematological parameters. Pv Asym individuals did not present common malaria symptoms (fever, headache, and chills), had a positive/negative microscopy result, a positive qPCR result, reported no history of antimalarial treatment during the last month, and were followed-up weekly until Day 21 (D21). Control individuals, had a negative malaria microscopy and qPCR result, no history of antimalarial treatment or malaria infections during the last three years, and no history of comorbidities or chronic infections.ResultsFrom the 2159 individuals screened during PS, data revealed a low but heterogeneous Pv prevalence across the communities (11.4%), where most infections were Asym (66.7%) and submicroscopic (82.9%). A total of 29 Asym, 49 Sym, and 30 control individuals participated in the nested case - control study (n=78). Ten of the individuals that were initially Asym at D0, experienced malaria symptoms during follow up and therefore, were included in the Sym group. 29 individuals remained Asym throughout all follow-ups. High levels of eosinophils were found in Asym individuals in comparison to Sym and controls.ConclusionFor the first-time, key epidemiological, hematological, and biochemical features are reported from Pv Asym infections from the Peruvian Amazon. These results should be considered for the design and reshaping of malaria control measures as the country moves toward malaria elimination.

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Short report: hematological outcomes in progression of malaria: a cohort study from district Dera Ismail Khan, Pakistan

Cited by 4 publications

References 0 publications

Prevalence of several infectious diseases in the District Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan

Prevalence of several infectious diseases in the District Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan

Will the malaria vaccine be accepted in Pakistan after the experience of Covid-19 experience?

Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon

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