Short Report: A Major Genotype of Japanese Encephalitis Virus Currently Circulating in Japan

Ma, Shao-Ping; Yoshida, Yasuko; Makino, Yoshihiro; Tadano, Masayuki; Ono, Takahiro; Ogawa, Masao

doi:10.4269/ajtmh.2003.69.151

Cited by 83 publications

(69 citation statements)

References 15 publications

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“…Before that time, genotype III was the most frequently isolated genotype in Japan. 14 Using the E gene sequences, we subdivided the isolates in this study into three clusters: A, B, and C ( Figure 4A ). There were 19-35 nucleotide differences among clusters A, B, and C ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…12,13 It has also been considered necessary to clarify how JEV strains were maintained in local areas after the most frequently isolated genotype changed from III to I in the 1990s 14 in Japan. A previous study of genetic change and variation in JEV genotype III in Taiwan 15 suggested that JEV isolates fall into three clusters by area and are genetically stable in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

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Continuity and Change of Japanese Encephalitis Virus in Toyama Prefecture, Japan

Obara¹,

Yamauchi²,

Watanabe³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Abstract. To determine the mechanisms of maintenance and evolution of Japanese encephalitis virus (JEV) in a temperate zone, we attempted to isolate JEV from mosquitoes and pigs in Toyama Prefecture, Japan. A total of 87 JEVs were isolated from female Culex tritaeniorhynchus mosquitoes and pigs during [2005][2006][2007][2008][2009]. The prevalence of JEV in Toyama Prefecture was seasonally late in comparison with that of the virus during 1966-1972. Furthermore, JEVs were isolated after the peak in the number of female Cx. tritaeniorhynchus . Among JEV strains isolated in this study, two distinct groups were observed within genotype I of the phylogeny generated from nucleotide sequence information derived from the envelope and capsid/premembrane genes: strains belonging to the major type were isolated during 2005-2009, and strains from the minor type were isolated only in 2007. The major type has exhibited gradual change in its envelope and capsid/ premembrane genes, and all isolates obtained in 2008 and 2009 had a novel deletion of seven nucleotides in the variable region of the 3′-untranslated region.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Continuity and Change of Japanese Encephalitis Virus in Toyama Prefecture, Japan

Obara¹,

Yamauchi²,

Watanabe³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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“…Consequently, all licensed inactivated and live-attenuated JE vaccines are derived from GIII JEV. However, the major genotype of JEV isolated in Japan changed from GIII to GI in the early 1990s (Ma et al, 2003;Yoshida et al, 2005). In recent years, a similar genotype shift has been observed in South Korea, northern Vietnam, China, Taiwan and Thailand Nam et al, 1996;Nga et al, 2004;Nitatpattana et al, 2008;Pan et al, 2011;Wang et al, 2007;Yang et al, 2004;Yun et al, 2010;Zhang et al, , 2011.…”

Section: Introductionmentioning

confidence: 99%

In vitro growth, pathogenicity and serological characteristics of the Japanese encephalitis virus genotype V Muar strain

Tajima

Yagasaki

Kotaki

et al. 2015

Journal of General Virology

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The characteristics of genotype V Japanese encephalitis virus (GV JEV) remain poorly understood as only two strains have been isolated to date. In this study, we examined the effects of the GV JEV Muar strain on in vitro growth and pathogenicity in mice; we also evaluated the efficacy of inactivated JEV vaccines against the Muar strain. Although growth of the Muar strain in mouse neuroblastoma N18 cells was clearly worse than that of the GIII Beijing-1 and GI Mie/41/2002 strains, neuroinvasiveness of the Muar strain was similar to that of the Beijing-1 strain and significantly higher than that of the Mie/41/2002 strain. The results of a plaque reduction neutralization test suggested that the neutralization ability of the JEV vaccines against the Muar strain was reduced compared with the GI and GIII strains. However, the protection potency of the JEV vaccine against the Muar strain was similar to that for the Beijing-1 strain in mice. Our data indicate that GV JEV has unique growth, virulence and antigenicity features.

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“…mosquitoes, from genotype III to genotype I, was witnessed in East Asia during the 1990s (11,12). These results and phylogenetic analysis of old JEV strains in Japan and Southeast Asia (11) strongly suggested that JEV could be transferred frequently from Southeast Asia to East Asia.…”

Section: Discussionmentioning

confidence: 61%

Isolation and Molecular Characterization of Banna Virus from Mosquitoes, Vietnam

Nabeshima

Nga

Guillermo

et al. 2008

Emerg. Infect. Dis.

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Short Report: A Major Genotype of Japanese Encephalitis Virus Currently Circulating in Japan

Cited by 83 publications

References 15 publications

Continuity and Change of Japanese Encephalitis Virus in Toyama Prefecture, Japan

Continuity and Change of Japanese Encephalitis Virus in Toyama Prefecture, Japan

In vitro growth, pathogenicity and serological characteristics of the Japanese encephalitis virus genotype V Muar strain

Isolation and Molecular Characterization of Banna Virus from Mosquitoes, Vietnam

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