Short Note

Abstract

Results and DiscussionMethoxyl values obtained using this method for two or more sets of vanillic acid and each lignin prepara-Holzforschung / Vol. 50 / 1996 / No. 6

Method Performance and Validation for Quantitative Analysis by 1H and 31P NMR Spectroscopy. Applications to Analytical Standards and Agricultural Chemicals

“…The early publications dealt primarily with 13 C NMR spectroscopy as a quantitative tool and addressed different aspects of optimizing conditions for data acquisition and subsequent processing to obtain reliable quantitative results. Recent applications of 13 C NMR spectroscopy include polymer chemistry, − clinical chemistry, and food chemistry studies. − Several articles dealing with lignin chemistry using quantitative 13 C NMR analysis have appeared, − as well as one on magic angle spinning 13 C NMR analysis of crystal polymorphs of an organic chemical in a complex solid matrix …”

Quantitative NMR Spectroscopy Using Coaxial Inserts Containing a Reference Standard: Purity Determinations for Military Nerve Agents

“…The method precision and accuracy are on the order of 0.5 and 1.0%, respectively, which rivals results from modern chromatographic techniques. The many reports on quantitative NMR spectroscopy appearing in the literature over the years, some of which are referenced herein, − support the applicability of NMR spectroscopy for quantitative chemical analysis. Of special note are the United States Pharmacopoeia and the British Pharmacopoeia, where the general quantitative NMR methodology is compendial.…”

“…Although more expensive and less sensitive than typical chromatographic techniques, such as gas chromatography/mass spectometry, NMR spectroscopy is less involved, because it does not require extensive sample preparation and generates results that are easily interpreted. NMR spectroscopy is an accurate quantitative technique when conducted under appropriate conditions; this potential was demonstrated more than 20 years ago. − Past reports have typically exploited proton − and 13 C NMR spectroscopy; − however, examples using 31 P − and other nuclei − are found in the literature. In addition, the accuracy and precision of NMR signal intensity measurements have recently been reviewed .…”