Short natural sleep is associated with higher T cell and lower NK cell activities

Fondell, Elinor; Axelsson, John; Franck, Kristina Træholt; Ploner, Alexander; Lekander, Mats; Bälter, Katarina; Gaines, Hans

doi:10.1016/j.bbi.2011.04.004

Cited by 64 publications

(34 citation statements)

References 42 publications

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“…Available data on the relationships between immune cell counts and sleep corresponds mostly to experiments of controlled, short-term sleep deprivation, which have shown either no effect on circulating T-cell counts [30,31], at least in the morning hours, or a decrease in circulating T-cell counts [12]. In addition, the few studies that, like ours, focused on self-reported habitual sleep did not find clear associations between T-cell counts and sleep duration [32], highlighting the need for further research on this topic.…”

Section: Discussionmentioning

confidence: 94%

Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study

et al. 2014

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Section: Discussionmentioning

confidence: 94%

Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study

et al. 2014

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“…The current study was able to explore changes in NKCA for 6 participants in the breast cancer survivor group, using a whole-blood flow cytometry assay adapted from Fondell et al 44 The NKCA results (measured as percentage target cell cytolysis in 500 mL of blood and expressed as mean ± SD) for the 6 participants in the breast cancer survivor group were 73.6% ± 30.3%, 74.4% ± 21.0%, 67.6% ± 12.5%, and 60.2% ± 37.1% at pre-exercise, immediately postexercise, at 2 hours postexercise, and at 24 hours postexercise, respectively. This exploratory analysis found that NKCA did not change significantly across the study time points for these 6 breast cancer survivors.…”

Section: Changes In Nk Cell Countsmentioning

confidence: 99%

Impact of Acute Intermittent Exercise on Natural Killer Cells in Breast Cancer Survivors

et al. 2015

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Background. Current research examining the effect of exercise on immune responses in cancer survivors is limited. Objective. The aim of this pilot study was to examine the effect of 1 bout of intermittent exercise on natural killer (NK) cell numbers in breast cancer survivors. Methods. A total of 9 women with stage I to III invasive breast cancer who were 3 to 6 months posttreatment and 9 sedentary women without a history of cancer completed 10 three-minute intervals of aerobic exercise on the cycle ergometer at 60% of VO 2peak (peak oxygen uptake). Whole blood samples were taken pre-exercise, immediately postexercise, and at 2 hours and 24 hours postexercise. NK cell counts were assessed using flow cytometry. Results. In both groups, NK cell counts significantly increased immediately postexercise compared with pre-exercise (P = .004-.008) and returned to near pre-exercise levels during recovery (P = .129-.547). Absolute NK cell counts were significantly lower in breast cancer survivors immediately postexercise when compared with controls (P = .046). Conclusions. The breast cancer survivor group exhibited NK cell responses to 30 minutes of moderate-intensity intermittent aerobic exercise that were comparable with that in the group of physically similar women without a history of cancer. Immune changes related to cancer treatments may be related to the lower absolute NK cell counts observed in the breast cancer survivor group. Although the results of this study are preliminary in nature, they suggest that this type of exercise does not disrupt this aspect of innate immunity in recent breast cancer survivors, thereby supporting current exercise recommendations for this population.

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“…The presence of a decreased level of CXCL9/MIG may be because sleep deprivation decreases the level of IFN-γ [6] . Natural killer cells are one of the major producers of IFN-γ [32] , and their activity has been reported to be depressed by sleep disturbances [33,34] .…”

Section: Discussionmentioning

confidence: 99%

Effects of Total Sleep Deprivation on Mouse Cytokine Levels

Yang¹,

Li²,

Xue³

2016

Neuroimmunomodulation

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Objective: Cytokines play an integral role in sleep/wake regulation. The objective of this study was to identify how total sleep deprivation affects cytokine levels. Methods: Male C57BL/6 mice were subjected to 48 h of total sleep deprivation produced by brief rotation of activity wheels or 3 different controls: home cage, a sedentary wheel, or forced activity. In addition, the serum levels of cytokines were analyzed using a mouse magnetic bead-based multiplex immunoassay. Results: The concentrations of some cytokines (fibroblast growth factor-basic [FGF-basic], leukemia inhibitory factor [LIF], and monokine induced by interferon-γ [MIG]) decreased significantly after total sleep deprivation. However, other cytokines (macrophage colony-stimulating factor, macrophage inflammatory protein-2, platelet-derived growth factor-bb, vascular endothelial growth factor) did not show any significant difference. Serum corticosterone levels did not differ significantly among the groups. Conclusion: The biochemical mechanisms responsible for sleep regulation are very complex. These results suggest the involvement of 3 cytokines (FGF-basic, LIF, and MIG) in sleep/wake regulation.

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Short natural sleep is associated with higher T cell and lower NK cell activities

Cited by 64 publications

References 42 publications

Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study

Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study

Impact of Acute Intermittent Exercise on Natural Killer Cells in Breast Cancer Survivors

Effects of Total Sleep Deprivation on Mouse Cytokine Levels

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