2021
DOI: 10.1186/s13195-021-00871-y
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Short leukocyte telomeres predict 25-year Alzheimer's disease incidence in non-APOE ε4-carriers

Abstract: Background Leukocyte telomere length (LTL) has been shown to predict Alzheimer’s disease (AD), albeit inconsistently. Failing to account for the competing risks between AD, other dementia types, and mortality, can be an explanation for the inconsistent findings in previous time-to-event analyses. Furthermore, previous studies indicate that the association between LTL and AD is non-linear and may differ depending on apolipoprotein E (APOE) ε4 allele carriage, the strongest genetic AD predictor. … Show more

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Cited by 36 publications
(18 citation statements)
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“…Telomere length (TL) is a well-known hallmark of biological aging [8] , being telomere shortening associated with age-related diseases [9] , [10] . For instance, shorter telomeres have been found in Alzheimer’s disease (AD) patients [11] , [12] , and it has been proposed as a valuable predictor of the AD incidence [13] . Nevertheless, its association with other neurodegenerative diseases and age-related processes remains unclear.…”
Section: Introductionmentioning
confidence: 99%
“…Telomere length (TL) is a well-known hallmark of biological aging [8] , being telomere shortening associated with age-related diseases [9] , [10] . For instance, shorter telomeres have been found in Alzheimer’s disease (AD) patients [11] , [12] , and it has been proposed as a valuable predictor of the AD incidence [13] . Nevertheless, its association with other neurodegenerative diseases and age-related processes remains unclear.…”
Section: Introductionmentioning
confidence: 99%
“…In the Rotterdam study ( N = 1961) a U-shaped association between TL and risk of AD was found, meaning that both, extremely shorter TL as well as extremely longer TL, were associated with an increased risk of AD, with stronger associations seen for APOE -ε4 carriers [ 75 ]. Alternatively, shorter TL has been shown to predict AD incidence only among APOE -ε4 non-carriers [ 76 ].…”
Section: Discussionmentioning
confidence: 99%
“…While the NIM index is associated with survival in cancer patients and all-cause mortality ( Gidron et al, 2018 ; Jarczok et al, 2021 ), no studies have looked at its role as predictor of age-related pathology such as Alzheimer’s disease. Telomere attrition is an antecedent to cellular senescence ( Campisi, 2000 , 2013 ; Brand, 2019 ; Coluzzi et al, 2019 ) and shorter telomeres has been identified as a risk factor for developing Alzheimer’s disease ( Hackenhaar et al, 2021 ). While our findings indicate that the NIM index is associated with telomere length, future studies should determine whether the NIM index can serve as a predictor of cognitive decline.…”
Section: Discussionmentioning
confidence: 99%
“…Both shorter telomeres and increased peripheral levels of inflammation are associated with increased risk for Alzheimer’s disease ( King et al, 2018 ; Wood, 2018 ; Hackenhaar et al, 2021 ). Whether shorter telomeres are a risk for cancer development might depend on cancer type ( Zhu et al, 2016 ), although damage-induced telomere dysfunction can occur irrespective of telomere length ( Victorelli and Passos, 2017 ; Brand, 2019 ).…”
Section: Introductionmentioning
confidence: 99%