Short-Latency Afferent Inhibition Modulation during Finger Movement

Asmussen, Michael J.; Jacobs, Mark F.; Lee, Kevin G.H.; Zapallow, Christopher M.; Nelson, Aimee J.

doi:10.1371/journal.pone.0060496

Cited by 45 publications

(57 citation statements)

References 55 publications

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“…We and others have shown that SAI is reduced during both the onset of muscle activity [6], [8], [9] and during sustained muscle contraction [6], [7]. Specifically, we observed reductions in SAI as early as movement preparation between an auditory “warning” and “go” cue and these reductions are likely cortically or sub-cortically mediated [6]. Previous work [8] has suggested that SAI may contribute to surround inhibition, particularly during EMG onset.…”

Section: Introductionsupporting

confidence: 62%

Modulation of Short-Latency Afferent Inhibition Depends on Digit and Task-Relevance

et al. 2014

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Short-latency afferent inhibition (SAI) occurs when a single transcranial magnetic stimulation (TMS) pulse delivered over the primary motor cortex is preceded by peripheral electrical nerve stimulation at a short inter-stimulus interval (∼20–28 ms). SAI has been extensively examined at rest, but few studies have examined how this circuit functions in the context of performing a motor task and if this circuit may contribute to surround inhibition. The present study investigated SAI in a muscle involved versus uninvolved in a motor task and specifically during three pre-movement phases; two movement preparation phases between a “warning” and “go” cue and one movement initiation phase between a “go” cue and EMG onset. SAI was tested in the first dorsal interosseous (FDI) and abductor digiti minimi (ADM) muscles in twelve individuals. In a second experiment, the origin of SAI modulation was investigated by measuring H-reflex amplitudes from FDI and ADM during the motor task. The data indicate that changes in SAI occurred predominantly in the movement initiation phase during which SAI modulation depended on the specific digit involved. Specifically, the greatest reduction in SAI occurred when FDI was involved in the task. In contrast, these effects were not present in ADM. Changes in SAI were primarily mediated via supraspinal mechanisms during movement preparation, while both supraspinal and spinal mechanisms contributed to SAI reduction during movement initiation.

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Section: Introductionsupporting

confidence: 62%

Modulation of Short-Latency Afferent Inhibition Depends on Digit and Task-Relevance

et al. 2014

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“…Nonetheless, the attentional dissociation observed here is consistent with a differential functional role of afferent input to the PA and AP I-wave circuits. PA SAI is reduced during finger movement with the reduction onset occurring during the preparatory phase (Asmussen et al, 2013) and involved in the surround inhibition of muscles not involved in the planned movement (Voller et al, 2006; Asmussen et al, 2014) suggesting a role in spatial and temporal priming of actions. Again, very little research has investigated the functional significance of the AP circuit however, the selective sensitivity of AP SAI to our attention manipulation is consistent with a modulatory mechanism that provides a substrate for cognitive influence upon selected actions.…”

Section: Discussionmentioning

confidence: 99%

“…Further, the positive relationship between the N20-P25 somatosensory evoked potential (SEP) and magnitude of SAI suggests that at least part of the network mediating SAI is dependent upon thalamo-cortical projections to somatosensory cortex (Bailey et al, 2016). Although there is a strong relationship between somatosensory afference and SAI, SAI is a malleable phenomenon modulated by movement timing and the relevance of a muscle to voluntary movement (Voller et al, 2006; Asmussen et al, 2013; Asmussen et al, 2014). Central cholinergic involvement, in addition to GABA A , in the generation of SAI (Ziemann et al, 2014) makes it a potential method to probe the effect of cognition on motor cortex excitability through attention-related afferent modulation.…”

Section: Introductionmentioning

confidence: 99%

Attention modulates specific motor cortical circuits recruited by transcranial magnetic stimulation

2017

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Skilled performance and acquisition is dependent upon afferent input to motor cortex. The present study used short-latency afferent inhibition (SAI) to probe how manipulation of sensory afference by attention affects different circuits projecting to pyramidal tract neurons in motor cortex. SAI was assessed in the first dorsal interosseous muscle while participants performed a low or high attention demanding visual detection task. SAI was evoked by preceding a suprathreshold transcranial magnetic stimulus with electrical stimulation of the median nerve at the wrist. To isolate different afferent intracortical circuits in motor cortex SAI was evoked using either posterior-anterior (PA) or anterior-posterior (PA) monophasic current. In an independent sample, somatosensory processing during the same attention demanding visual detection tasks was assessed using somatosensory evoked potentials (SEP) elicited by median nerve stimulation. SAI elicited by AP TMS was reduced under high compared to low visual attention demands. SAI elicited by PA TMS was not affected by visual attention demands. SEPs revealed that the high visual attention load reduced the fronto-central P20-N30 but not the contralateral parietal N20-P25 SEP component. P20-N30 reduction confirmed the visual attention task altered sensory afference. The current results offer further support that PA and AP TMS recruit different neuronal circuits. AP circuits may be one substrate by which cognitive strategies shape sensorimotor processing during skilled movement by altering sensory processing in premotor areas.

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“…The peripheral stimulation was given 25ms prior to the TMS pulse for each movement state to elicit SAI. The fixed interval of 25ms was frequently used in previous studies for SAI (Asmussen et al, 2013). …”

Section: Methodsmentioning

confidence: 99%

“…The motor evoked potential (MEP) amplitude is substantially reduced when preceded by peripheral nerve stimulation at a short latency (~20 ms), an effect known as short-latency afferent inhibition (SAI) (Tokimura et al , 2000). A previous study showed that SAI was reduced in the active hand muscle during both the onset and maintenance phases of movement (Asmussen et al , 2013), but SAI in surrounding muscle at the onset phase showed contradictory results (Voller et al , 2006, Richardson et al , 2008). SAI in the surrounding muscle during the maintenance movement phase has never been tested.…”

Section: Introductionmentioning

confidence: 96%

Dynamic modulation of corticospinal excitability and short-latency afferent inhibition during onset and maintenance phase of selective finger movement

Cho

Panyakaew

Thirugnanasambandam

et al. 2016

Clinical Neurophysiology

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Objective During highly selective finger movement, corticospinal excitability is reduced in surrounding muscles at the onset of movement but this phenomenon has not been demonstrated during maintenance of movement. Sensorimotor integration may play an important role in selective movement. We sought to investigate how corticospinal excitability and short-latency afferent inhibition changes in active and surrounding muscles during onset and maintenance of selective finger movement. Methods Using transcranial magnetic stimulation (TMS) and paired peripheral stimulation, input-output recruitment curve and short-latency afferent inhibition (SAI) were measured in the first dorsal interosseus and abductor digiti minimi muscles during selective index finger flexion. Results: Motor surround inhibition was present only at the onset phase, but not at the maintenance phase of movement. SAI was reduced at onset but not at the maintenance phase of movement in both active and surrounding muscles. Conclusions Our study showed dynamic changes in corticospinal excitability and sensorimotor modulation for active and surrounding muscles in different movement states. SAI does not appear to contribute to motor surround inhibition at the movement onset phase. Also, there seems to be different inhibitory circuit(s) other than SAI for the movement maintenance phase in order to delineate the motor output selectively when corticospinal excitability is increased in both active and surrounding muscles. Significance This study enhances our knowledge of dynamic changes in corticospinal excitability and sensorimotor interaction in different movement states to understand normal and disordered movements.

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Short-Latency Afferent Inhibition Modulation during Finger Movement

Cited by 45 publications

References 55 publications

Modulation of Short-Latency Afferent Inhibition Depends on Digit and Task-Relevance

Modulation of Short-Latency Afferent Inhibition Depends on Digit and Task-Relevance

Attention modulates specific motor cortical circuits recruited by transcranial magnetic stimulation

Dynamic modulation of corticospinal excitability and short-latency afferent inhibition during onset and maintenance phase of selective finger movement

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