Short halt in vaping modifies cardiorespiratory parameters and urine metabolome: a randomized trial

Abstract

Propylene glycol and glycerol are e-cigarette constituents that facilitate liquid vaporization and nicotine transport. As these small hydrophilic molecules quickly cross the lung epithelium, we hypothesized that short-term cessation of vaping in regular users would completely clear aerosol deposit from the lungs and reverse vaping-induced cardiorespiratory toxicity. We aimed to assess the acute effects of vaping and their reversibility on biological/clinical cardiorespiratory parameters [serum/urine pneumoproteins, hemodynamic parameters, lung-function test and diffusing capacities, transcutaneous gas tensions (primary outcome), and skin microcirculatory blood flow]. Regular e-cigarette users were enrolled in this randomized, investigator-blinded, three-period crossover study. The periods consisted of nicotine-vaping (nicotine-session), nicotine-free vaping (nicotine-free-session), and complete cessation of vaping (stop-session), all maintained for 5 days before the session began. Multiparametric metabolomic analyses were used to verify subjects’ protocol compliance. Biological/clinical cardiorespiratory parameters were assessed at the beginning of each session (baseline) and after acute vaping exposure. Compared with the nicotine- and nicotine-free-sessions, a specific metabolomic signature characterized the stop-session. Baseline serum club cell protein-16 was higher during the stop-session than the other sessions ( P < 0.01), and heart rate was higher in the nicotine-session ( P < 0.001). Compared with acute sham-vaping in the stop-session, acute nicotine-vaping (nicotine-session) and acute nicotine-free vaping (nicotine-free-session) slightly decreased skin oxygen tension ( P < 0.05). In regular e-cigarette-users, short-term vaping cessation seemed to shift baseline urine metabolome and increased serum club cell protein-16 concentration, suggesting a decrease in lung inflammation. Additionally, acute vaping with and without nicotine decreased slightly transcutaneous oxygen tension, likely as a result of lung gas exchanges disturbances.

World No Tobacco Day 2020

“…The main ingredients of e-cigarette liquids are 1) solvents such as propylene glycol and glycerol, together with 2) nicotine in liquid form (in nicotinized e-cigarette liquids), and 3) flavoring agents. The pulmonary toxicity of the primary constituents of vaporizing solvents such as propylene glycol and glycerol alone in e-cigarette liquids (14,15) has been documented in multiple reports by our authors (14,15). Similarly, the pulmonary toxicity of flavoring agents employed in e-cigarette liquids has also been documented, with cinnamaldehyde-containing solvents both inhibiting lung innate immune cell function (20) and suppressing bronchial epithelial cell ciliary motility through dysregulation of mitochondrial function (19).…”

Lung Damage Caused by Heated Tobacco Products and Electronic Nicotine Delivery Systems: A Systematic Review

“…Severe neurologic damage was reported in a case of cytotoxic lesion of the splenium of the corpus callosum in a 17-year-old patient, a daily consumer of THC vaping [ 85 ]. Benefits of short-term e-cigarette cessation in regular users include improving airway health status [ 86 ].…”

E-cigarette Smoking (Vaping) and Markers of Vascular Wall Damage in Young Subjects without Cardiovascular Disease

“…Хорошо известно негативное влияние курения на сосудистую стенку, состояние эндотелия и развитие атеросклероза. Наиболее распространенным интегральным маркером функционального состояния сосудистой стенки является эндотелий-зависимая вазодилатация, которая по данным ряда исследований значимо снижается на фоне традиционного курения [6] и вейп-курения [8,16,[19][20][21][22][23]. Antoniewicz L. и соавт.…”