Short-duration treatment for catheter-associated urinary tract infections in critically ill trauma patients

Jarrell, Andrew; Wood, George C.; Ponnapula, Supriya; Magnotti, Louis J.; Croce, Martin A.; Swanson, Joseph M.; Boucher, Bradley A.; Fabian, Timothy C.

doi:10.1097/ta.0000000000000822

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…A retrospective study of critically ill trauma patients with CAUTI showed that 3 to 5 days of antibiotic therapy led to a clinical cure rate of 82%. 62 Another retrospective study of febrile UTIs among patients with neurogenic bladder found no difference in the clinical cure rate at 1 month posttreatment when comparing <10 days, 10 to 15 days or >15 days of antibiotic treatment. 63 More recently, a randomized, double-blind, placebo-controlled, noninferiority trial compared 7-and 14-day courses of antibiotics for men and women with a febrile UTI.…”

Section: Length Of Therapymentioning

confidence: 98%

Diagnosis, Treatment, and Prevention of Urinary Tract Infections in Post-Acute and Long-Term Care Settings: A Consensus Statement From AMDA's Infection Advisory Subcommittee

Ashraf

Gaur

Bushen

et al. 2020

Journal of the American Medical Directors Association

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Section: Length Of Therapymentioning

confidence: 98%

Diagnosis, Treatment, and Prevention of Urinary Tract Infections in Post-Acute and Long-Term Care Settings: A Consensus Statement From AMDA's Infection Advisory Subcommittee

Ashraf

Gaur

Bushen

et al. 2020

Journal of the American Medical Directors Association

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“…CAUTI is the most common cause of health-care-associated infection (HAI) worldwide, accounting for 40% of all HAIs (7, 8), and often leads to secondary bloodstream infection, with a 7-day mortality rate of more than 30% (7, 9–11). Current guidelines recommend antibiotic treatments lasting 7 to 14 days to prevent CAUTI (8, 12); however, control of CAUTIs has become a major challenge due to the development and dissemination of antibiotic resistances among the bacteria that cause HAI (9, 10). …”

Section: Introductionmentioning

confidence: 99%

Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections

Flores-Mireles

Walker

Potretzke

et al. 2016

mBio

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Gram-positive bacteria in the genus Enterococcus are a frequent cause of catheter-associated urinary tract infection (CAUTI), a disease whose treatment is increasingly challenged by multiantibiotic-resistant strains. We have recently shown that E. faecalis uses the Ebp pilus, a heteropolymeric surface fiber, to bind the host protein fibrinogen as a critical step in CAUTI pathogenesis. Fibrinogen is deposited on catheters due to catheter-induced inflammation and is recognized by the N-terminal domain of EbpA (EbpANTD), the Ebp pilus’s adhesin. In a murine model, vaccination with EbpANTD confers significant protection against CAUTI. Here, we explored the mechanism of protection using passive transfer of immune sera to show that antisera blocking EbpANTD-fibrinogen interactions not only is prophylactic but also can act therapeutically to reduce bacterial titers of an existing infection. Analysis of 55 clinical CAUTI, bloodstream, and gastrointestinal isolates, including E. faecalis, E. faecium, and vancomycin-resistant enterococci (VRE), revealed a diversity of levels of EbpA expression and fibrinogen-binding efficiency in vitro. Strikingly, analysis of 10 strains representative of fibrinogen-binding diversity demonstrated that, irrespective of EbpA levels, EbpANTD antibodies were universally protective. The results indicate that, despite diversity in levels of fibrinogen binding, strategies that target the disruption of EbpANTD-fibrinogen interactions have considerable promise for treatment of CAUTI.

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“…Another study [75] included 192 patients with catheter-associated urinary tract infection and compared treatment durations of 3-5 days and 14 days. Seventy-seven of the patients were given a 3-5-day course.…”

Section: Pyelonephirits/catheter-associated Urinary System Infectionmentioning

confidence: 99%

Rational Antibiotic Use: How Much Can Duration of Antibiotic Therapy Be Shortened?

Yılmaz¹,

Atalar²,

Kostakoğlu³

2019

mjima

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Short-duration treatment for catheter-associated urinary tract infections in critically ill trauma patients

Abstract: Therapeutic study, level V.

Cited by 10 publications

References 11 publications

Diagnosis, Treatment, and Prevention of Urinary Tract Infections in Post-Acute and Long-Term Care Settings: A Consensus Statement From AMDA's Infection Advisory Subcommittee

Diagnosis, Treatment, and Prevention of Urinary Tract Infections in Post-Acute and Long-Term Care Settings: A Consensus Statement From AMDA's Infection Advisory Subcommittee

Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections

Rational Antibiotic Use: How Much Can Duration of Antibiotic Therapy Be Shortened?

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