Short Course Radiotherapy Concomitant with Temozolomide in GBM Patients: A Phase II Study

Abstract

To improve local control and OS, a more aggressive treatment schedule should be explored. The related higher necrosis risk and its implications regarding local control deserve further investigation.

Late Radiation Outcomes of Patients with Newly Diagnosed Glioblastoma Treated with Accelerated Hyperfractionated Radiotherapy and Temozolomide

“…To date, a number of dose-escalation trials have been conducted to improve the local control using different techniques such as altered fractionation, stereotactic radiosurgery, brachytherapy, or IMRT. [12,[15][16][17][18][19][20][30][31][32][33][34][35] Increasing the treatment dose by altered fractionation has been used for a long time in rapidly growing tumors. The aim is to exploit radiobiological advantages.…”

“…[10] After the use of TMZ with RT became standard in GB management, RT dose-escalation studies have been accelerated again to improve survival further. [13,[16][17][18]32,33,40,41] Kaul et al compared 64 patients who underwent accelerated hyperfractionated RT with 67 patients who underwent conventional RT, and they found no significant difference between the two groups. [40] Similarly, Badiyan et al failed to show improvement in survival rate in patients who received high-dose RT with TMZ compared to those who received the standard-dose RT.…”