Short course of quinine plus a single dose of sulfadoxine/pyrimethamine for Plasmodium falciparum malaria

Matsiégui, Pierre-Blaise; Missinou, Michel A.; Necek, Magdalena; Issifou, Saadou; Kremsner, Peter G.

doi:10.1007/s00508-006-0657-3

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…However, until recently, there has been a lack of adequate pediatric drug formulations for the treatment of young children, leading to diffi culties in drug administration and adherence to recommended regimens in the most vulnerable patient population [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon

Bouyou-Akotet

Ramharter

Ngoungou

et al. 2010

Wien Klin Wochenschr

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Wirksamkeit, Verträglichkeit und Sicherheit einer neuen pädiatrischen Artesunat-Mefl oquin Medikamentenformulierung zur Therapie der Malaria tropica Zusammenfassung. Pädiatrische Medikamentenformulierungen sind ein wichtiger Fortschritt in der Th erapie von afrikanischen Kindern, die an Malaria tropica erkrankt sind. In dieser klinischen Studie wurde die Wirksamkeit, Sicherheit und Verträglichkeit einer neuen pädiatrischen Artesunat-Mefl oquin Koformulierung im Vergleich mit einer Tablettenformulierung evaluiert. Einundsiebzig pädiatrische Patienten am Albert Schweitzer Spital in Lambaréné, Gabun, die an unkomplizierter Malaria tropica litten, wurden nach Körpergewicht stratifi ziert, um mit der pädiatrischen (10 -20 kg; n = 41) oder der Tabletten-Formulierung (20 -40 kg; n = 30) therapiert zu werden. Die PCR korrigierte Heilungsrate war 100 % am Tag 28. Die häufi gsten Nebenwirkungen waren Erbrechen (17 %), abdominelle Schmerzen (11 %) und Cephalea (17 %). Diese Studie bestätigt die hervorragende Wirksamkeit und gute Verträglichkeit von Artesunat-Mefl oquin zur Th erapie pä-diatrischer Patienten in Afrika. Summary.Pediatric drug formulations of artemisinin combination therapies are urgently needed for improving the treatment of children suff ering from uncomplicated malaria. Th e aim of this clinical trial was to evaluate the effi cacy, safety and tolerability of a novel pediatric fi xeddose granule formulation of artesunate-mefl oquine and a new co-blister tablet formulation. A total of 71 children aged 1-13 years suff ering from uncomplicated falciparum malaria were stratifi ed into two groups according to weight: 10-20 kg, pediatric group (n = 41); 20-40 kg, tablet group (n = 30). All the children were treated once daily for three days: the pediatric group received the novel granule formulation, the tablet group received the co-blister tablets. Th e PCR-corrected cure rate on day 28 was evaluated. Th ere was no reappearance of parasitemia during the follow-up period and the day-28 cure rate was therefore 100% in per-protocol analysis. In intention-to-treat analysis the cure rates were 95% in the pediatric group and 97% in the tablet group. Th e most frequent adverse events were vomiting (17%), abdominal pain (11%) and headache (17%). Th is study confi rms the excellent effi cacy and favorable safety and tolerability profi le of a novel pediatric artesunate-mefl oquine formulation for treatment in African children.

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Section: Introductionmentioning

confidence: 99%

Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon

Bouyou-Akotet

Ramharter

Ngoungou

et al. 2010

Wien Klin Wochenschr

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“…For malaria treatment, all patients received an infusion of 250 mL of 5% glucose with 12 mg/kg of quinine dihydrochloride every 12 h for 72 h, then a single dose of oral sulphadoxine/pyrimethamine (500 mg/25 mg tablet) was given according to weight category (body weight ≤ 10.0 kg: 0.25 tablet; 10.1–14.0 kg: 0.5 tablet; 14.1–20.0 kg: 1.0 tablet; 20.1–30.0 kg: 1.5 tablets) after the last infusion. This regimen has been found to be efficacious in the study area [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Antipyretic effect of ibuprofen in Gabonese children with uncomplicated falciparum malaria: a randomized, double-blind, placebo-controlled trial

Matsiégui

Missinou

Necek

et al. 2008

Malar J

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Short course of quinine plus a single dose of sulfadoxine/pyrimethamine for Plasmodium falciparum malaria

Abstract: A very high efficacy can be reached using a 3-day course of quinine plus a single dose of sulfadoxine/pyrimethamine for the treatment of non-severe hospitalized malaria cases in our study area.

Cited by 2 publications

References 26 publications

Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon

Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon

Antipyretic effect of ibuprofen in Gabonese children with uncomplicated falciparum malaria: a randomized, double-blind, placebo-controlled trial

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