Short course chemotherapy for tuberculous lymphadenitis in children.

Jawahar, M S; Sivasubramanian, S; Vijayan, V K; Ramakrishnan, C. V.; Paramasivan, C. N.; Selvakumar, Vanaja; Paul, Sare; Tripathy, S.P.; Prabhakar, R

doi:10.1136/bmj.301.6748.359

Cited by 46 publications

(33 citation statements)

References 6 publications

(2 reference statements)

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“…In 5/9 patients with reported failure, the unfavourable outcome was bacteriologically proven (9/553=1.6%) (table 1) [8,12]. In one of these patients, the residual lymph node resolved spontaneously within 3 months and another patient with a residual node of 1 cm at the end of treatment was lost to follow-up [13].…”

Section: Resultsmentioning

confidence: 99%

“…Nodes were present after treatment in 143/423=34% of the patients [7,8,10,11,13]. The size of the nodes was not reported, or the nodes were not suspected of harbouring disease.…”

Section: Resultsmentioning

confidence: 99%

“…During treatment, new nodes or enlargement of existing lymph nodes occurred in 79/468=17% [7,8,10,11,13]. Nodes were present after treatment in 143/423=34% of the patients [7,8,10,11,13].…”

Section: Resultsmentioning

confidence: 99%

“…In children, the isoniazid dose was 15±30 mg . kg -1 twice or thrice weekly [8,9]. The same dose of rifampicin and ethambutol was given to adults and children (mg .…”

Section: Resultsmentioning

confidence: 99%

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Cervical tuberculous lymphadenitis

Eyselbergs¹,

Snoeckx²,

Beeck³

et al. 2011

Journal of the Belgian Society of Radiology

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The aim of the study was to determine the optimal duration of treatment for patients with tuberculous lymphadenitis.The Medline database was searched for relevant articles published between 1978± 1997. Inclusion criteria were study populations of patients with predominantly cervical tuberculous lymphadenitis in whom the diagnosis had been confirmed bacteriologically and/or histologically, or was made probable by using clinical and laboratory markers. Treatment management had to include at least isoniazid, rifampicin and pyrazinamide and a follow-up of at least 12 months after the end of treatment. Patients with resistance to rifampicin and pyrazinamide and previous treatment for tuberculosis were excluded. The number of patients who relapsed after treatment was calculated.The study population in eight out of the 35 articles retrieved were suitable for analysis. Some concerned comparative studies. There were eight treatment schedules of 6 months' duration and three schedules of 9 months' duration. Treatment for 6 months resulted in a tuberculous lymphadenitis relapse rate of 13/422=3.3% (95% confidence interval: 1.7±5.5), with a mean follow-up of 31 months after completion of treatment. Treatment for 9 months resulted in a relapse rate of 3/112=2.7% (95% confidence interval: 0.6±7.8), with a mean follow-up of 20 months.Despite the limitations of the literature available, 6 months of therapy is probably sufficient for patients with tuberculous lymphadenitis.

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Section: Resultsmentioning

confidence: 99%

“…Nodes were present after treatment in 143/423=34% of the patients [7,8,10,11,13]. The size of the nodes was not reported, or the nodes were not suspected of harbouring disease.…”

Section: Resultsmentioning

confidence: 99%

“…During treatment, new nodes or enlargement of existing lymph nodes occurred in 79/468=17% [7,8,10,11,13]. Nodes were present after treatment in 143/423=34% of the patients [7,8,10,11,13].…”

Section: Resultsmentioning

confidence: 99%

“…In children, the isoniazid dose was 15±30 mg . kg -1 twice or thrice weekly [8,9]. The same dose of rifampicin and ethambutol was given to adults and children (mg .…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cervical tuberculous lymphadenitis

Eyselbergs¹,

Snoeckx²,

Beeck³

et al. 2011

Journal of the Belgian Society of Radiology

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“…Among the extrapulmonary manifestations, tuberculous lymphadenitis is the most frequently encountered form of tuberculosis [ 1,21. The isolation of tubercle bacilli from lymph node biopsy specimens remains the confirmatory test for the diagnosis of the disease.…”

Section: Introductionmentioning

confidence: 99%

Transportation of lymph node biopsy specimens in selective Kirchner's liquid medium for culture of tubercle bacilli

Vanajakumar

Selvakumar²,

Jawahar³

et al. 1997

Journal of Medical Microbiology

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Lymph node biopsy specimens, obtained from 297 paediatric and adult patients with tuberculous lymphadenitis at Madurai, were transported in selective Kirchner's liquid medium (KL-T) to the Tuberculosis Research Centre, Madras and processed for culture. Mycobacterium tuberculosis was isolated from 201 (68%) specimens. Of the 192 specimens received within 4 days of resection, 134 (69.8%) yielded M. tuberculosis on culture and of the 105 specimens received after 5 days, 67 (63.8%) were culture positive; the difference was not statistically significant. By incubating KL-T alone further, after removing the gland for processing, it was found that mere contact with the excised node during transportation was enough to retrieve 77 (38.3%) of the total of 201 positive isolates obtained, the delay did not affect the culture positivity rate. Thus, lymph node specimens for culture of tubercle bacilli can be stored in the refrigerator for up to 15 days and transported in KL-T at ambient temperature for 18-20 h without any loss in culture positivity.

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