Short communication: Paracheck‐Pf®: a new, inexpensive and reliable rapid test for <i>P. falciparum</i> malaria

Proux, Stéphane; Hkirijareon, Lily; Ngamngonkiri, Chatee; McConnell, Stephen; Nosten, François

doi:10.1046/j.1365-3156.2001.00694.x

Cited by 65 publications

(56 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One case of microscopically diagnosed P. vivax infection was not detected by both RDTs, this case was only detected by the blood film (parasitemia 0.02%). The results obtained by both the Bio Tina Pf/Pan Mal and OptiMAL tests is significantly affected by the level of malaria parasite in peripheral blood which is concluded by other researchers in previous studies ( Iqbal et al, 1999;Fryauff et al, 0222;Ricci et al, 2000;Singh et al, 2000;Proux et al, 2001). Furthermore, one case of P. falciparum infection diagnosed by microscopy and OptiMAL test in the present study was not detected by the Bio Tina Pf/Pan Mal test, the same finding had been observed in earlier studies which concluded that falsenegative dipstick test results may be detected even in samples with higher parasitemias, but the underlying reason is not known (Anonymous, 1996;Karbwang et al, 1996 ;Humar et al, 1997 ;Palmer et al, 1998 ;Van den et al, 1998;Cooke et al, 1999 ).…”

Section: Discussionsupporting

confidence: 57%

“…The sensitivity of the RDTs was studied and reported by earlier studies to be influenced by the level of malaria parasite in peripheral blood ( Iqbal et al, 1999;Fryauff et al, 0222;Ricci et al, 2000;Singh et al, 2000;Proux et al, 2001), which could be dangerous, as to ignore malaria diagnosis in patient that could lead to serious complications as proper treatment not instituted in time. The assessment of a negative result in this condition will be judged mainly by the clinical features of the patient.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Two Rapid Diagnostic Tests with Conventional Microscopy for Detection of Malaria parasites

2017

Aust. J. Basic & Appl. Sci.

View full text Add to dashboard Cite

Malaria is a major cause of death mostly in tropical and sub-tropical countries. The constant increase of population movements, leads to spread of infections previously limited to endemic areas. In this urgent situation, efficient diagnostic method is essential for the management and control of malaria. The aim of the present study was to compare two RDTs with conventional microscopy as diagnostic tools for detection of falciparum and non falciparum malaria in travelers and migrating people from malaria endemic areas to Egypt. A total of 112 blood samples were studied by light microscopy, microscopy positive malaria samples were tested by two malaria RDTs. Malarial parasites were observed in 28 cases(25%) with conventional light microscopy, of which the OptiMAL test detected 27 positive cases (96%) and only 26 cases ( 93 %) were positive by Bio Tina Pf/Pan Mal test. Microscopy showed 15 P. falciparum and 13 P. vivax cases. The OptiMAL dipstick revealed 15 positive P. falciparum and 12 positive blood samples for non falciparum malaria while the Bio Tina Pf/Pan Mal test revealed 14 P. falciparum and 12 non P. falciparum malaria. The OptiMAL sensitivities in the present study was 100% and 92% for P. falciparum and non falciparum malaria respectively while the Bio Tina Pf/Pan Mal method sensitivities was 93% and 92 % for P. falciparum and non falciparum malaria respectively. Microscopic examination for malaria parasite by thin and thick blood films is the gold standard technique for malaria diagnosis.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Comparison of Two Rapid Diagnostic Tests with Conventional Microscopy for Detection of Malaria parasites

2017

Aust. J. Basic & Appl. Sci.

View full text Add to dashboard Cite

show abstract

“…Malaria infection was identified using peripheral blood smear to detect malaria parasites, and via the rapid diagnostic test (RDT), Paracheck-pf ® (Orchid Biomedical Systems, Goa, India) that detects the presence of histidine-rich protein 2 (HRP2) antigen and is both highly sensitive (92.3%) and specific (97.2%) when compared with microscopy. 29,30 For this analysis, we used the results of the RDT, which are characterized by high sensitivity but lower specificity as the tests detect HRP2 antigen that persists in the bloodstream after clearance of the parasite. 31 Children with a positive RDT were offered treatment with weight-based dosing of Coartem ® artemether/ lumefantrine (Novartis Pharma AG, Basel, Switzerland) at the household according to guidelines from the Uganda NMCP.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and Factors Associated with Anemia Among Children Under 5 Years of Age—Uganda, 2009

Menon

Yoon

2015

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Anemia in children under 5 years of age, defined by the World Health Organization as a hemoglobin concentration < 11 g/dL, is a global public health problem. According to the 2006 Demographic Health Survey, the prevalence of anemia among children under five in Uganda was 72% in 2006. The 2009 Uganda Malaria Indicator Survey was conducted in late 2009 and revealed that over 60% of children less than 5 years of age were anemic and that over half of children tested positive for malaria via a rapid diagnostic test. Children with concomitant malaria infection, and in households without any type of mosquito net were more likely to be anemic, confirming that children under 5 years, are vulnerable to both the threat of malaria and anemia and the beneficial effect of malaria prevention tools. However, prevention and treatment of other factors associated with the etiology of anemia (e.g., iron deficiency) are likely necessary to combat the toll of anemia in Uganda.

show abstract

“…We calculated costs in Euros (as of August 2004, 1 Euro ¼ 1.219 USD) per 10 000 febrile patients consulting in a period of 1 month (Table 1). This unit rate seemed appropriate, as it allowed us to factor in timedependent costs (such as salaries), and since caseload is actually far higher in most serious epidemics (WHO 1998 Estimates of RDT sensitivity and specificity are the average of manufacturer specifications and the following studies: (Proux et al 2001;Guthmann et al 2002;Huong et al 2002;Singh et al 2002) RDT-based strategy 95% Specificity…”

Section: Parameter Inputsmentioning

confidence: 99%

Operational response to malaria epidemics: are rapid diagnostic tests cost‐effective?

Rolland¹,

Checchi

Pinoges³

et al. 2006

Tropical Med Int Health

View full text Add to dashboard Cite

Summaryobjective To compare the cost-effectiveness of malaria treatment based on presumptive diagnosis with that of malaria treatment based on rapid diagnostic tests (RDTs).methods We calculated direct costs (based on experience from Ethiopia and southern Sudan) and effectiveness (in terms of reduced over-treatment) of a free, decentralised treatment programme using artesunate plus amodiaquine (AS + AQ) or artemether-lumefantrine (ART-LUM) in a Plasmodium falciparum epidemic. Our main cost-effectiveness measure was the incremental cost per false positive treatment averted by RDTs.results As malaria prevalence increases, the difference in cost between presumptive and RDT-based treatment rises. The threshold prevalence above which the RDT-based strategy becomes more expensive is 21% in the AS + AQ scenario and 55% in the ART-LUM scenario, but these thresholds increase to 58 and 70%, respectively, if the financing body tolerates an incremental cost of 1 € per false positive averted. However, even at a high (90%) prevalence of malaria consistent with an epidemic peak, an RDT-based strategy would only cost moderately more than the presumptive strategy: +29.9% in the AS + AQ scenario and +19.4% in the ART-LUM scenario. The treatment comparison is insensitive to the age and pregnancy distribution of febrile cases, but is strongly affected by variation in non-biomedical costs. If their unit price were halved, RDTs would be more cost-effective at a malaria prevalence up to 45% in case of AS + AQ treatment and at a prevalence up to 68% in case of ART-LUM treatment.conclusion In most epidemic prevalence scenarios, RDTs would considerably reduce over-treatment for only a moderate increase in costs over presumptive diagnosis. A substantial decrease in RDT unit price would greatly increase their cost-effectiveness, and should thus be advocated. A tolerated incremental cost of 1 € is probably justified given overall public health and financial benefits. The RDTs should be considered for malaria epidemics if logistics and human resources allow.

show abstract

Short communication: Paracheck‐Pf®: a new, inexpensive and reliable rapid test for P. falciparum malaria

Cited by 65 publications

References 4 publications

Comparison of Two Rapid Diagnostic Tests with Conventional Microscopy for Detection of Malaria parasites

Comparison of Two Rapid Diagnostic Tests with Conventional Microscopy for Detection of Malaria parasites

Prevalence and Factors Associated with Anemia Among Children Under 5 Years of Age—Uganda, 2009

Operational response to malaria epidemics: are rapid diagnostic tests cost‐effective?

Contact Info

Product

Resources

About