Short Communication: Mucocutaneous Leishmaniasis in HIV-Related Immune Reconstitution Syndrome

Lee, Grace L.; Woods, Kenneth L.; Clark, L. C.; Peters, Sara; Wong, Henry K.; McGwire, Bradford S.

doi:10.1089/aid.2015.0075

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…Paragraph 4: there is no reasonable evidence suggesting MCL is generally associated with VL or immunosuppression. All references supporting this statement (11)(12)(13)(14)(15)(16)(17)(18)(19) are case reports informing unusual clinical presentations. It's highly recommended to authors review https://doi.org/10.1016/B978-0-323-55512-8.00104-6 for a better understanding of the pathobiology and risk factors of MCL.…”

Section: Data Availabilitymentioning

confidence: 89%

“…Unusual manifestations as DisL or purely oral Leishmaniasis should be considered in immunocompromised patients [13][14][15][16] . In immunocompetent patients, primary and exclusive mucosal involvement in the head and neck region is uncommon; lesions affecting the buccal mucosa exclusively are even rarer 1,[15][16][17][18][19] . In our series of cases, four cases (57.1%) presented some level of immunological deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…There is no specific standardization for mucocutaneous leishmaniasis therapy 17,22 . The cases we reported were submitted to different therapeutic plans, adjusted to each patient.…”

Section: Discussionmentioning

confidence: 99%

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Orofacial manifestations of mucocutaneous leishmaniasis: a case series from Brazil

et al. 2020

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Dentists play a fundamental role in the early diagnosis of oral leishmaniasis. Although these lesions are rare at oral mucosa, this is one of the manifestations sites of the disease This study reports seven clinical cases of orofacial mucocutaneous leishmaniasis. All had leishmaniasis diagnosis confirmed by laboratory tests, with orofacial involvement. Five out of the seven cases were males, and in four cases, patients had associated comorbidities. Late diagnosis was observed, resulting in treatment delay and increased hospitalization stay. One patient had severe psychological consequences due to facial deformity. The lack of differential diagnosis due the great variability of clinical presentation of the lesions and frequent unspecific histopathology represent a challenge for the dentist. In two reported cases, there were unspecific biopsy results. This series of cases highlights the importance of a multidisciplinary approach in the diagnosis and treatment of oral and perioral leishmaniasis. Patients with atypical lesions, originating from or living in endemic regions, should be investigated for leishmaniasis. These procedures could avoid delays in diagnosis and decrease the risk of disease dissemination.

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