Short Communication: High Prevalence of Vitamin D Deficiency in HIV-Infected and HIV-Uninfected Pregnant Women

Eckard, Allison Ross; Leong, Traci; Avery, Ann; Castillo, Marina Duran; Bonilla, Hector; Storer, Norma; Labbato, Danielle; Khaitan, Alka; Tangpricha, Vin; McComsey, Grace A.

doi:10.1089/aid.2012.0384

Cited by 9 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found that 25(OH)D concentrations in serum cord blood were <30 ng/mL in 100% of subjects from both groups. The only variables associated with higher serum 25(OH)D concentrations were white race and non-Hispanic ethnicity [ 12 ]. These data agreed with previous observations asserting that vitamin D deficiency not only contributes to HIV disease progression and mortality in HIV-infected pregnant women, but also increases the overall risk of mother-to-child transmission by 46% [ 13 ] and the risk of death in newborns by 61% during follow-up [ 13 ].…”

Section: Prevalence Of Hypovitaminosis D In Hiv-infected Subjectsmentioning

confidence: 99%

Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder

Mansueto

Seidita

Vitale

et al. 2015

BioMed Research International

102

View full text Add to dashboard Cite

Hypovitaminosis D is a worldwide disorder, with a high prevalence in the general population of both Western and developing countries. In HIV patients, several studies have linked vitamin D status with bone disease, neurocognitive impairment, depression, cardiovascular disease, high blood pressure, metabolic syndrome, type 2 diabetes mellitus, infections, autoimmune diseases like type 1 diabetes mellitus, and cancer. In this review, we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. We analysed the extent of the problem, pathogenic mechanisms, clinical implications, and potential benefits of vitamin D supplementation in HIV-infected subjects.

show abstract

Section: Prevalence Of Hypovitaminosis D In Hiv-infected Subjectsmentioning

confidence: 99%

Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder

Mansueto

Seidita

Vitale

et al. 2015

BioMed Research International

102

View full text Add to dashboard Cite

show abstract

“…Epidemiological data suggest an association between low serum 25(OH)D levels (used to define vitamin D status) and increased risk of adverse women’s reproductive health outcomes [ 12 , 13 ]. Vitamin D deficiency is prevalent in HIV-1-infected women, where upwards of 60% of individuals have levels lower than 50 nmol/L [ 14 ], and is associated with HIV disease progression and mortality [ 15 , 16 ]. A recent phase I clinical trial found enhanced antimicrobial activity in the plasma of HIV-infected individuals following one month of vitamin D supplementation [ 17 ]; however, little is known regarding vitamin D immune-regulation in the female reproductive tract (FRT), or how vitamin D status may impact mucosal HIV acquisition [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women

et al. 2020

View full text Add to dashboard Cite

While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important.

show abstract

Vitamin D supplementation for women during pregnancy

De-Regil

Palacios

Lombardo

et al. 2016

Cochrane Database of Systematic Reviews

443

302

View full text Add to dashboard Cite

BACKGROUND: Vitamin D deficiency or insufficiency is thought to be common among pregnant women. Vitamin D supplementation during pregnancy has been suggested as an intervention to protect against adverse pregnancy outcomes. OBJECTIVES: To examine whether oral supplements with vitamin D alone or in combination with calcium or other vitamins and minerals given to women during pregnancy can safely improve maternal and neonatal outcomes. METHODS: Search methods: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (23 February 2015), the International Clinical Trials Registry Platform (31 January 2015), the Networked Digital Library of Theses and Dissertations (28 January 2015) and also contacted relevant organisations (31 January 2015). Selection criteria: Randomized and quasi-randomized trials with randomization at either individual or cluster level, evaluating the effect of supplementation with vitamin D alone or in combination with other micronutrients for women during pregnancy. Data collection and analysis: Two review authors independently i) assessed the eligibility of studies against the inclusion criteria ii) extracted data from included studies, and iii) assessed the risk of bias of the included studies. Data were checked for accuracy. The quality of the evidence was assessed using the GRADE approach. MAIN RESULTS: In this updated review we included 15 trials assessing a total of 2833 women, excluded 27 trials, and 23 trials are still ongoing or unpublished. Nine trials compared the effects of vitamin D alone versus no supplementation or a placebo and six trials compared the effects of vitamin D and calcium with no supplementation. Risk of bias in the majority of trials was unclear and many studies were at high risk of bias for blinding and attrition rates. • Vitamin D alone versus no supplementation or a placebo Data from seven trials involving 868 women consistently show that women who received vitamin D supplements alone, particularly on a daily basis, had higher 25-hydroxyvitamin D than those receiving no intervention or placebo, but this response was highly heterogeneous. Also, data from two trials involving 219 women suggest that women who received vitamin D supplements may have a lower risk of pre-eclampsia than those receiving no intervention or placebo (8.9% versus 15.5%; risk ratio (RR) 0.52; 95% CI 0.25 to 1.05, low quality). Data from two trials involving 219 women suggest a similar risk of gestational diabetes among those taking vitamin D supplements or no intervention/ placebo (RR 0.43; 95% CI 0.05, 3.45, very low quality). There were no clear differences in adverse effects, with only one reported case of nephritic syndrome in the control group in one study (RR 0.17; 95% CI 0.01 to 4.06;

show abstract

Short Communication: High Prevalence of Vitamin D Deficiency in HIV-Infected and HIV-Uninfected Pregnant Women

Cited by 9 publications

References 44 publications

Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder

Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder

Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women

Vitamin D supplementation for women during pregnancy

Contact Info

Product

Resources

About