Abstract:In this study, we investigated the possibility of differential effects of protease inhibitor (PI)-containing (PI + ) and PI-sparing (PI À ) antiretroviral therapies (ART) on CD8 + T cell apoptosis. We retrospectively analyzed both PD-1 expression and CD8+ T cell apoptosis in a cross-sectional study of HIV-positive adolescents and young adults (mean age ¼ 17.4 years), with perinatally or behaviorally acquired HIV infection. Fifty-one specimens of cryopreserved peripheral blood mononuclear cells (PBMCs) were ana… Show more
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