Short Communication: Comparative Evaluation of Anticoagulatory Activity of Ethylenediamine Tetra-Acetic Acid (Edta) and Heparin For Haematological Analysis.

Comparative pathogenicity of Trypanosoma brucei rhodesiense strains in Swiss white mice and Mastomys natalensis rats

“…A further major advantage of Mastomys rats over mice is that the former has a bigger body mass making it possible to monitor changes in the size of organs. Mastomys is also more suitable for blood sample collection for hematological studies (Ojok and Weiss, 1995) which is more problematic in mice due to low circulating blood volume (Kibugu et al, 2010). This is the first report on the susceptibility of Mastomys natalensis rats to T .b.…”

“…The utility of murine models is however limited by small circulating blood volume available for sampling risking animal exsanguination (Kibugu et al, 2010). This is particularly a concern in pathogenesis studies requiring frequent bleeding.…”