Short Communication: Antibacterial activity of certain Saudi Arabian medicinal plants used in folk medicine against different groups of bacteria

Al-Ghanayem, Abdullah A.; Sobeai, Sanad M. Al; Alhussaini, Mohammed S.; Joseph, Babu; Saadabi, A.M.

doi:10.13057/nusbiosci/n090409

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Plant active ingredients can be good candidates for the biological activity of plants besides nanoparticles (NPs) formulation since are known as reducing and capping agents. The importance of L. scindicus as a medicinal plant was earlier studied and the antifungal and antibacterial abilities of P. turgidum were reported 5 , 6 , however, no valid report about their anticancer ability and their ability in NPs fabrication.…”

Section: Introductionmentioning

confidence: 99%

Bioactive silver nanoparticles fabricated using Lasiurus scindicus and Panicum turgidum seed extracts: anticancer and antibacterial efficiency

Alburae,

Alshamrani,

Mohammed

2024

Sci Rep

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Applying extracts from plants is considered a safe approach in biomedicine and bio-nanotechnology. The present report is considered the first study that evaluated the seeds of Lasiurus scindicus and Panicum turgidum as biogenic agents in the synthesis of silver nanoparticles (AgNPs) which had bioactivity against cancer cells and bacteria. Assessment of NPs activity against varied cell lines (colorectal cancer HCT116 and breast cancer MDA MBA 231 and MCF 10A used as control) was performed beside the antibacterial efficiency. Different techniques (DLS, TEM, EDX and FTIR) were applied to characterize the biosynthesized AgNPs. The phytochemicals from both L. scindicus and Panicum turgidum were identified by GC–MS analysis. Spherical monodisperse NPs at average diameters of 149.6 and 100.4 nm were obtained from seed extract of L. scindicus (L-AgNPs) and P. turgidum, (P-AgNPs) respectively. A strong absorption peak at 3 keV is observed by the EDX spectrum in the tested NPs. Our study provided effective NPs in mitigating the tested cell lines and the lowest IC50 were 7.8 and 10.30 for MDA MB231 treated by L-AgNPs and P-AgNPs, respectively. Both fabricated NPs might differentially target the MDA MB231 cells compared to HCT116 and MCF10A. Ultrastructural changes and damage for the NPs-treated MDA MB231 cells were studied using TEM and LSM analysis. Antibacterial activity was also observed. About 200 compounds were identified in L. scindicus and P. turgidum by GC–MS analysis might be responsible for the NPs reduction and capping abilities. Efficient NPs against cancer cells and microbes were obtained, however large-scale screening is needed to validate our findings.

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Section: Introductionmentioning

confidence: 99%

Bioactive silver nanoparticles fabricated using Lasiurus scindicus and Panicum turgidum seed extracts: anticancer and antibacterial efficiency

Alburae,

Alshamrani,

Mohammed

2024

Sci Rep

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“…There are earlier studies establishing a wide range of antibacterial activities for Acacia ehrenbergiana [ 4 , 12 , 13 , 22 ]. On testing the antibacterial activities of Acacia ehrenbergiana, a significant effect was found for the acetone and ethanol extracts on Gram-negative E. coli .…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis of Acaciaehrenbergiana (Hayne) Grown in Qatar: Identification of Active Ingredients and Their Biological Activities

Thotathil¹,

Rizk²,

Fakrooh³

et al. 2022

Molecules

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Acacia ehrenbergiana (Hayne), also known as Salam, is a highly drought resistant shrub distributed in North and East Africa, and the Arabian Peninsula. The plant is gathered for its gum and fiber, and is an important legume species for indigenous populations. In this study, the phytochemical analysis, antibacterial, and antioxidant properties of various alcoholic and aqueous extracts of Acacia ehrenbergiana grown in Qatar were investigated. The qualitative phytochemical screening of this species exhibited the presence of glycosides, tannins, flavonoids, terpenoids, saponins, phenol, and anthraquinones in various extracts. The agar diffusion method was performed to check the antibacterial activity. The acetone and ethanol extracts showed 85% antibacterial activity of the control against Gram-negative E. coli, while the acetone extract had 65% activity against the Bacillus Gram-positive species. The highest activity against Staphylococcus aureus was 65% for the butanol extract. The antioxidant capacities were evaluated by the DPPH method. Various extracts exhibited antioxidant activities similar to or higher than standard antioxidants, with the highest percent inhibition of 95% for the acetone and ethanol extracts. The acetone extracts were further purified by reverse phase combiflash chromatography followed by HPLC. Three of the pure compounds isolated were subjected to MS, FTIR, and NMR spectral analysis and were found to be stigmasterol, spinasterol, and theogallin. In conclusion, the observed antibacterial and antioxidant activities as well as the presence of secondary metabolites with potential medicinal activities makes Acacia ehrenbergiana a potent valuable endemic medicinal plant.

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“…Several groups have reported that Gram-positive bacteria are more susceptible to plant extracts (Al-Ghanayem et al 2017;Boussaada et al 2008;Semeniuc et al 2017). In contrast, we observed that the hexane extract of L. aduncum had stronger antimicrobial activity against Gram-negative bacteria than Gram-positive bacteria.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and antibacterial activity of extract from two species of mosses: Leucobryum aduncum and Campylopus schmidii

2020

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Abstract. Makajanma MM, Taufik I, Faizal A. 2020. Antioxidant and antibacterial activity of extract from two species of mosses: Leucobryum aduncum and Campylopus schmidii. Biodiversitas 21: 1751-1758. Plants produce a plethora of natural compounds of medicinal value. Although most plant-derived drugs have been identified in angiosperms, some species of mosses from the genera Leucobryum and Campylopus also exhibit antioxidant and antibacterial activity. The research aimed to evaluate the antioxidant and antibacterial activities of two species of these genera, Leucobryum aduncum and Campylopus schmidii, that are common in Taman Wisata Alam Gunung Tangkuban Perahu, West Java. Plants were collected, dried, and extracted in n-hexane or methanol. Antioxidant activity was evaluated by determining the concentration of extract that resulted in 50% reduction of 1,1-diphenyl-2-picrylhydrazine (DPPH) in the DPPH assay. These concentrations were >2000 mg/L for L. aduncum extracts and 1329.02 ± 7.8 mg/L for C. schmidii extracts; these large values are consistent with little antioxidant activity. Antibacterial activity was quantified as the ability of the extracts to inhibit the growth of the Gram-negative and Gram-positive bacteria Escherichia coli and Staphylococcus aureus, respectively. Nonpolar extracts of L. aduncum inhibited the growth of E. coli >50% at a concentration of 32 mg extract/L. Based on combined gas chromatography-mass spectrometry, the antibacterial activity in the non-polar extracts of L. aduncum was attributed to the lipophilic compounds 1-nonadecene, 5-eicosene, and cyclotetracosane. Thus, L. aduncum is a promising candidate as a source of new antibiotics.

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Short Communication: Antibacterial activity of certain Saudi Arabian medicinal plants used in folk medicine against different groups of bacteria

Cited by 5 publications

References 8 publications

Bioactive silver nanoparticles fabricated using Lasiurus scindicus and Panicum turgidum seed extracts: anticancer and antibacterial efficiency

Bioactive silver nanoparticles fabricated using Lasiurus scindicus and Panicum turgidum seed extracts: anticancer and antibacterial efficiency

Phytochemical Analysis of Acaciaehrenbergiana (Hayne) Grown in Qatar: Identification of Active Ingredients and Their Biological Activities

Antioxidant and antibacterial activity of extract from two species of mosses: Leucobryum aduncum and Campylopus schmidii

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