Short communication: Acute hypoxia does not alter mitochondrial abundance in naked mole-rats

Chabris, Nathalie C. Marks de; Sabir, Soulene; Perkins, Guy; Cheng, Hang; Ellisman, Marc H.; Pamenter, Matthew E.

doi:10.1016/j.cbpa.2022.111343

Cited by 1 publication

(1 citation statement)

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“…Past studies on the effect of hypoxia on heart or skeletal muscle mitochondria have focused on long-term exposure to hypoxia [3,4,11,12]. On the other hand, studies on the effect of hypoxia on brain mitochondria were tested as short-term (3 or 48 h) or after ischemia-reperfusion injury, with conflicting results [10,13,14]. However, no previous research has delved into the acute effects of hypoxia on heart and brain mitochondria in both sexes following exercise.…”

Section: Introductionmentioning

confidence: 99%

Male and Female Mitochondria Respond Differently after Exercising in Acute Hypoxia

Lai,

Loy,

Isola

et al. 2023

Biomedicines

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The use of hypoxic devices among athletes who train in normobaric hypoxia has become increasingly popular; however, the acute effects on heart and brain metabolism are not yet fully understood. This study aimed to investigate the mitochondrial bioenergetics in trained male and female Wistar rats after acute hypoxia training. The experimental plan included exercising for 30 min on a treadmill in a Plexiglas cage connected to a hypoxic generator set at 12.5% O2 or in normoxia. After the exercise, the rats were sacrificed, and their mitochondria were isolated from their brains and hearts. The bioenergetics for each complex of the electron transport chain was tested using a Clark-type electrode. The results showed that following hypoxia training, females experienced impaired oxidative phosphorylation through complex II in heart subsarcolemmal mitochondria, while males had an altered ADP/O in heart interfibrillar mitochondria, without any change in oxidative capacity. No differences from controls were evident in the brain, but an increased electron transport system efficiency was observed with complex I and IV substrates in males. Therefore, the study’s findings suggest that hypoxia training affects the heart mitochondria of females more than males. This raises a cautionary flag for female athletes who use hypoxic devices.

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