Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers

Abstract

The reprogramming of cellular metabolism is frequently linked to tumorigenesis. Glucose, fatty acids, and amino acids are the specific substrates involved in how an organism maintains metabolic equilibrium. The HADH gene codes for the short-chain L-3-hydroxyacyl-CoA dehydrogenase (HADH), a crucial enzyme in fatty acid oxidation that catalyzes the third phase of fatty acid oxidation in mitochondria. Increasing data suggest that HADH is differentially expressed in various types of malignancies and is linked to cancer development and progression. The significance of HADH expression in tumors and its potential mechanisms of action in the onset and progression of certain cancers are summarized in this article. The possible roles of HADH as a target and/or biomarker for the detection and treatment of various malignancies is also described here.

Comparative toxicity of polystyrene, polypropylene, and polyethylene nanoplastics on Artemia franciscana nauplii: a multidimensional assessment

“…8). The Had-like gene, encrypting 3-hydroxyacyl-CoA dehydrogenase enzyme that is linked with fatty acid oxidation and PTEN enzyme transcription, 56,57 was differentially expressed by different types of nanoplastics. Downregulation of this gene by PENP and upregulation by PSNP indicates an alteration in energy homeostasis and cell proliferation of A. franciscana nauplii.…”

Investigation of seasonal changes in lipid synthesis and metabolism-related genes in the oviduct of Chinese brown frog (<em>Rana dybowskii</em>)

“… 26 The hadh gene encodes short-chain L-3-hydroxy acyl-CoA dehydrogenase, a key enzyme in fatty acid β-oxidation responsible for catalyzing the third stage of mitochondrial fatty acid oxidation. 27 Many hibernating animals utilize increased fatty acid catabolism as a survival strategy. 28 …”