Short-chain fructooligosaccharide supplementation during gestation and lactation or after weaning differentially impacts pig growth and IgA response to influenza vaccination

Bourgot, Cindy Le; Ferret‐Bernard, Stéphanie; Blat, Sophie; Apper, Emmanuelle; Huërou‐Luron, Isabelle Le

doi:10.1016/j.jff.2016.04.018

Cited by 23 publications

(28 citation statements)

References 47 publications

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“…Back fat thickness at weaning tended to be higher in sows fed scFOS compared to those fed control diet while feed intake was similar between the 2 groups. Le Bourgot et al [11] observed similar effects on backfat thickness in sows fed with scFOS diet for the 4 last week of gestation and lactation. Late-pregnancy and lactation are specific physiological periods during which sows may become insulin-resistant and mobilize their energy storage [4,20].…”

Section: Supplementation Of Sows With Scfos Modifies Reproductive Permentioning

confidence: 77%

“…Similarly, Le Bourgot et al [11] observed a modulation of faecal and blood concentrations of specific IgA in piglets vaccinated against Influenza and supplemented with scFOS. They also observed a positive and significant relationship between blood specific IgA and IgG.…”

Section: Supplementation Of Piglets With Scfos Modulates Immune Responsementioning

confidence: 82%

“…In this context, Le Bourgot et al [11] recently published data on effects of an early supplementation with scFOS on immune response after a vaccine against Influenza.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Dietary Supplementation with Short-Chain Fructooligosaccharides in Lactating Sows and Newly Weaned Piglets on Reproductive Performance of Sows, Immune Response and Growth Performance of Piglets from Birth to Slaughter

Apper¹,

Meymerit²,

Bodin³

et al. 2016

J Anim Res Nutr

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Objective: The effects of an early-life dietary supplementation with short-chain fructooligosaccharides (scFOS) on immune response and growth performance of pigs from birth to slaughter were evaluated. The hypothesis was that scFOS have long-term effects on immune response, and growth performance. Methods:One hundred and twenty-nine sows received a control diet (CTRL, 10 g/d maltodextrins) or a diet supplemented with scFOS (10 g/d) from d 109 of gestation to the weaning of the piglets.After weaning, the piglets of each litter were divided into two groups to receive the CTRL or the scFOS diet (1.2 g/d maltodextrin or scFOS) during the pre-starter period. At 53 and 74 d of age, the piglets were vaccinated against Influenza.Performance of sows and composition of colostrum were measured. Blood serum of the piglets was sampled one d prior vaccination, at d 74 and 95 to measure Influenza-IgG levels. The growth parameters of the piglets were recorded from birth to slaughter. Results:Supplementation of the sows with scFOS decreased farrowing duration (p=0.012), colostrum fat content (p=0.006) and increased IgG content in colostrum of sows with parity of 4 or higher (p=0.006) without modifying the performance of suckling piglets. Back fat thickness at weaning tended to be higher in supplemented sows (p=0.091). Diet with scFOS improved growth performance during the breeding period, resulting in reduced feeding time needed to reach a 120 kg body weight at slaughter. Piglets fed scFOS had higher Influenza-IgG titer (p=0.05) after vaccination against Influenza virus. Conclusion:These data suggest scFOS supplementation of sows during suckling period and of piglets during the postweaning period leads to long-term positive effects on growth of fattening pigs and to better physiological conditions of sows.

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Section: Supplementation Of Sows With Scfos Modifies Reproductive Permentioning

confidence: 77%

Section: Supplementation Of Piglets With Scfos Modulates Immune Responsementioning

confidence: 82%

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Effect of Dietary Supplementation with Short-Chain Fructooligosaccharides in Lactating Sows and Newly Weaned Piglets on Reproductive Performance of Sows, Immune Response and Growth Performance of Piglets from Birth to Slaughter

Apper¹,

Meymerit²,

Bodin³

et al. 2016

J Anim Res Nutr

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“…Oligosaccharides usually resist enzymatic hydrolysis and absorption in upper gastrointestinal tract, but can be fermented in large bowel by a number of bacteria [9]. Interestingly, non-digestible oligosaccharides have prebiotic activity, as they can promote body health by increasing populations of bene cial microbes and/or their metabolic activity [10]. FOS is composed of fructose and glucose units, which refers speci cally to short chains (3-6 units) of fructose units bound by β-(2-1) linkages that are attached to a terminal glucose unit [11].…”

mentioning

confidence: 99%

“…Oligosaccharides including the FOS have been previously reported to improve growth performance and gut health in a variety of animal species [12]. For instance, FOS not only promoted the growth of weaning pigs, but also effectively reduced the colonization of pathogenic bacteria in the intestine [10].…”

mentioning

confidence: 99%

Fructooligosaccharides improves growth performance and intestinal epithelium function in weaned pigs exposure to Enterotoxigenic Escherichia coli

Liu

Chen

et al. 2020

Preprint

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Background This study was conducted to explore the protective potential of Fructooligosaccharides (FOS) against Enterotoxigenic Escherichia coli (ETEC)-induced inflammation and intestinal injury in weaned pigs. Methods Twenty-four weaned pigs were randomly assigned into three groups: (1) non-challenge (CON), (2) ETEC-challenge (ECON), and (3) ETEC challenge + 250 mg/kg FOS (EFOS). On day 19, non-challenged pigs were orally infused with sterilized culture while pigs in other groups were orally infused with ETEC (2.5 × 1010 colony-forming units). After 3 days, pigs were slaughtered for sample collection. Results We show that ETEC-challenged significantly reduced average daily gain (ADG); however, FOS improved the ADG (P < 0.05) and apparent digestibility of crude protein (CP), gross energy (GE), and ash in the ETEC-challenged pigs (P < 0.05). FOS reduced plasma concentrations of IL-1β and TNF-α, and elevated the concentrations of immunoglobulin A (IgA) and immunoglobulin M (IgM) (P < 0.05). Interestingly, FOS elevated villus height in duodenum, and elevated the ratio of villus height to crypt depth in the duodenum and ileum in the ETEC-challenged pigs (P < 0.05). Moreover, FOS increased lactase activity in the duodenum and ileum (P < 0.05). The activities of sucrase and alkaline phosphatase (AKP) were higher in EFOS group than in the ECON group (P < 0.05). Importantly, FOS up-regulated the expressions of critical genes in intestinal epithelium function such as zonula occludens-1 (ZO-1), L-type amino acid transporter-1 (LAT1), and cationic amino acid transporter-1 (CAT1) in the duodenum and the expressions of ZO-1 and glucose transporter-2 (GLUT2) in the jejunum (P < 0.05). FOS also up-regulated the expressions of occludin, fatty acid transporter-4 (FATP4), sodium glucose transport protein 1 (SGLT1), and GLUT2 in the ileum (P < 0.05). FOS significantly increased the concentrations of acetic acid, propionic acid and butyric acid in the cecal digesta. Additionally, FOS reduced the populations of Escherichia coli, but elevated the populations of Bacillus and Bifidobacterium in the caecal digesta (P < 0.05). Conclusions These results suggested that FOS can improve the growth performance and intestinal health in weaned pigs upon ETEC challenge, which was associated with suppressed inflammatory responses and improved intestinal epithelium functions and microbiota.

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Fructooligosaccharides as Prebiotics, their Metabolism, and Health Benefits

Rosa¹,

Flores-Gallegos²,

Ascacio‐Valdés³

et al. 2022

Probiotics, Prebiotics and Synbiotics

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Short-chain fructooligosaccharide supplementation during gestation and lactation or after weaning differentially impacts pig growth and IgA response to influenza vaccination

Cited by 23 publications

References 47 publications

Effect of Dietary Supplementation with Short-Chain Fructooligosaccharides in Lactating Sows and Newly Weaned Piglets on Reproductive Performance of Sows, Immune Response and Growth Performance of Piglets from Birth to Slaughter

Effect of Dietary Supplementation with Short-Chain Fructooligosaccharides in Lactating Sows and Newly Weaned Piglets on Reproductive Performance of Sows, Immune Response and Growth Performance of Piglets from Birth to Slaughter

Fructooligosaccharides improves growth performance and intestinal epithelium function in weaned pigs exposure to Enterotoxigenic Escherichia coli

Fructooligosaccharides as Prebiotics, their Metabolism, and Health Benefits

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