Short-chain fatty acids: possible regulators of insulin secretion

Rosli, Nur Suraya Ashikin; Gani, Shafinaz Abd; Khayat, Mohd Ezuan; Zaidan, Uswatun Hasanah; Ismail, Ahmed; Rahim, Mohd Badrin Hanizam Abdul

doi:10.1007/s11010-022-04528-8

Cited by 9 publications

(5 citation statements)

References 102 publications

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“…The present study missed the SCFA data of the samples, but the microbial community changes show a higher abundance in SCFA-producing bacteria genera after PSPA intervention, so it may be another way PSPA controls blood glucose levels. Studies found the mechanisms of SCFA in diabetes are via secretion of several gut hormones, G-protein coupled receptors (GPR) activation, and signal transduction [ 54 , 55 ]. Humans and rodents [ 56 , 57 ] studies reported that acetate, propionate, and butyrate increased glucagon-like peptide-1 (GLP-1) hormone, which binds to GLP-1 receptor to stimulate insulin secretion, but the anorectic hormone peptide YY was response to propionate, then regulate energy homeostasis and glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus

Mi,

Hu,

Zhao

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus

Mi,

Hu,

Zhao

et al. 2024

Heliyon

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“…The fermentation process serves as a metabolic engine, converting complex carbohydrates into metabolic byproducts, which encompass gases and beneficial SCFAs. This sustains the growth and activity of microbial communities (Rosli et al 2023). This section examines the role of carbohydrates as essential fuel sources, detailing how they shape gut microbiota composition and functionality.…”

Section: Interply Between Nondigestible Carbohydrates and Gut Microbiotamentioning

confidence: 99%

Nondigestible carbohydrates and gut microbiota: A dynamic duo in host defense

Zong,

Luo,

Liu

et al. 2024

Anim. nutriomics

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The sophisticated relationship between the intake of dietary carbohydrates and host immunity is mediated in large part by the gut microbiota. This comprehensive review explores the multifaceted connections linking human gut microbiota with nondigestible carbohydrate metabolism and immune responses, highlighting the critical importance of this symbiotic relationship in maintaining overall host health. Understanding the mechanisms by which gut microbiota act as a bridge between carbohydrate intake and host immunity has significant implications for precision nutrition strategies and the development of therapeutic interventions.

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“…These changes in gut microbiota result from the increased availability of fiber and resistant starch in the colon to support expansion of specific bacteria capable of fiber fermentation, and short-chain fatty acid production is the result [27]. Short-chain fatty acids are a source of energy for colonocytes, act to strengthen the intestinal barrier, regulate immune responses, and have other beneficial effects on many metabolic processes including insulin secretion [28][29][30]. Firmicutes are known for their energy harvesting capabilities and tend to be increased in obese individuals.…”

Section: Dietary Patternsmentioning

confidence: 99%

Dietary approaches for normalizing dysbiosis induced by high-fat, obesogenic diets

Djurić¹

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewGiven the world-wide problem of obesity, this review considers what types of dietary changes can be utilized to minimize the adverse effects of an obesogenic diet on the intestinal microbiota.Recent findingsIn rodents fed high-fat diets containing lard or Western blend fats to induce obesity, switching to high-fat diets formulated to contain higher amounts of fiber or fiber-containing foods, plant extracts, omega-3 fatty acids or whole grains has beneficial effects on body weight, metabolic alterations, and the intestinal microbiota. Several studies show that the intestinal microbiota has a role in mediating the beneficial health effects of these dietary factors. Many aspects of the microbiota observed in animals when healthful dietary components were added to the feed have also been observed in humans who follow healthful dietary patterns.SummaryThe data shows that specific foods and macronutrients can normalize the obesity-associated microbiota and improve metabolic health. These findings support the design of dietary interventions that would allow individuals to focus on diet quality independently of weight loss to mitigate the adverse sequelae of obesity.

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Short-chain fatty acids: possible regulators of insulin secretion

Cited by 9 publications

References 102 publications

Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus

Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus

Nondigestible carbohydrates and gut microbiota: A dynamic duo in host defense

Dietary approaches for normalizing dysbiosis induced by high-fat, obesogenic diets

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