Short-chain fatty acids: possible regulators of insulin secretion

Rosli, Nur Suraya Ashikin; Gani, Shafinaz Abd; Khayat, Mohd Ezuan; Zaidan, Uswatun Hasanah; Ismail, Ahmed; Rahim, Mohd Badrin Hanizam Abdul

doi:10.1007/s11010-022-04528-8

Cited by 7 publications

(4 citation statements)

References 102 publications

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“…The present study missed the SCFA data of the samples, but the microbial community changes show a higher abundance in SCFA-producing bacteria genera after PSPA intervention, so it may be another way PSPA controls blood glucose levels. Studies found the mechanisms of SCFA in diabetes are via secretion of several gut hormones, G-protein coupled receptors (GPR) activation, and signal transduction [ 54 , 55 ]. Humans and rodents [ 56 , 57 ] studies reported that acetate, propionate, and butyrate increased glucagon-like peptide-1 (GLP-1) hormone, which binds to GLP-1 receptor to stimulate insulin secretion, but the anorectic hormone peptide YY was response to propionate, then regulate energy homeostasis and glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus

Mi,

Hu,

Zhao

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus

Mi,

Hu,

Zhao

et al. 2024

Heliyon

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“…These changes in gut microbiota result from the increased availability of fiber and resistant starch in the colon to support expansion of specific bacteria capable of fiber fermentation, and short-chain fatty acid production is the result [27]. Short-chain fatty acids are a source of energy for colonocytes, act to strengthen the intestinal barrier, regulate immune responses, and have other beneficial effects on many metabolic processes including insulin secretion [28][29][30]. Firmicutes are known for their energy harvesting capabilities and tend to be increased in obese individuals.…”

Section: Dietary Patternsmentioning

confidence: 99%

Dietary approaches for normalizing dysbiosis induced by high-fat, obesogenic diets

Djurić¹

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewGiven the world-wide problem of obesity, this review considers what types of dietary changes can be utilized to minimize the adverse effects of an obesogenic diet on the intestinal microbiota.Recent findingsIn rodents fed high-fat diets containing lard or Western blend fats to induce obesity, switching to high-fat diets formulated to contain higher amounts of fiber or fiber-containing foods, plant extracts, omega-3 fatty acids or whole grains has beneficial effects on body weight, metabolic alterations, and the intestinal microbiota. Several studies show that the intestinal microbiota has a role in mediating the beneficial health effects of these dietary factors. Many aspects of the microbiota observed in animals when healthful dietary components were added to the feed have also been observed in humans who follow healthful dietary patterns.SummaryThe data shows that specific foods and macronutrients can normalize the obesity-associated microbiota and improve metabolic health. These findings support the design of dietary interventions that would allow individuals to focus on diet quality independently of weight loss to mitigate the adverse sequelae of obesity.

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“…Short-chain fatty acids (SCFA), namely propionic, acetic, butyric, isobutyric, isovaleric, valeric, isocaproic, and caproic acids, are important metabolites formed in the large intestine as a result of fermentation by predominantly anaerobic bacteria of dietary fibres [4,5]. It has been established that SCFA through FFAR2 receptors in β-cells of the pancreas stimulate insulin secretion, have an anti-apoptotic effect on pancreatic islets, and are also important modulators of intestinal hormone secretion and lipogenesis [6,7]. Their role in the prevention of cardio-vascular complications in diabetes is due to a number of proven effects: SCFAs have a direct antioxidant effect, contributing to the neutralization of free radicals; inhibit the production of anti-inflammatory factors [8]; participate in the regulation of adipogenesis; affect the appetite, contributing to the feeling of satiety; increase tissue sensitivity to insulin; have a positive effect on the metabolism of lipids and glucose; maintain electrolyte balance; improve intestinal peristalsis [9,10].…”

Section: Introductionmentioning

confidence: 99%

Study of the influence of GLP-1 receptor agonists on the metabolic activity of the intestinal microbiota in patients with type 2 DM

Zinych,

Stepanov,

Shyshkan-Shyshova

et al. 2023

SR:MS

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The aim: to investigate the peculiarities of the metabolic activity of the intestinal microbiota in patients with type 2 diabetes under the influence of glucagon-like peptide-1 receptor agonist therapy. Materials and methods: 21 patients with type 2 diabetes mellitus were included in the study, the average age was 57.2±8.53 years (M±SD), the HbA1c level was 8.29±0.88 % (M±SD). Patients were prescribed raGLP-1 at the maximum tolerated dose for 6 months. Before and after the course of treatment, indicators of body composition were determined by the bioelectrical impedance method (TANITA BC-545N analyzer, Japan), characteristics of carbohydrate metabolism and the lipid spectrum of blood serum, as well as the concentration of GLP-1, trimethylamine-N-oxide (TMAO) by the immunoenzymatic method, of short-chain fatty acids (SCFA) by the method of chromatographic research. Results. After 6 months of therapy with liraglutide against the background of a statistically significant decrease in fasting blood glucose and HbA1c levels (p<0.05), a decrease in body mass index and waist circumference (p<0.05), a decrease in the content of visceral (p<0.05 ) and total fat (p<0.05) in patients with type 2 diabetes, there was a decrease in the concentration of TMAO in blood serum (p<0.05) and an increase in the concentration of SCFA: acetic, propionic (p<0.05) in the coprofiltrate and a tendency to increase in the level of butyric acids. Data analysis also established an increase in the concentration of endogenous GLP-1 in the blood (p<0.05). Conclusions. The detected changes in microbial metabolites may indicate a positive effect of raGLP-1 on the composition of the intestinal microbiota and its metabolic activity in patients with T2DM, which in turn contributes to the improvement of endogenous secretion of incretins

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Short-chain fatty acids: possible regulators of insulin secretion

Cited by 7 publications

References 102 publications

Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus

Purple sweet potato anthocyanins normalize the blood glucose concentration and restore the gut microbiota in mice with type 2 diabetes mellitus

Dietary approaches for normalizing dysbiosis induced by high-fat, obesogenic diets

Study of the influence of GLP-1 receptor agonists on the metabolic activity of the intestinal microbiota in patients with type 2 DM

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