Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro

McBride, David A.; Dorn, Nicholas C; Yao, Mina; Johnson, W. T.; Wang, Wei; Bottini, Nunzio; Shah, Naseem

doi:10.1007/s13346-022-01284-6

Cited by 13 publications

(5 citation statements)

References 55 publications

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“…Evidence shows that an imbalance in the Th17/Treg ratio is a prognostic factor for thyroid gland damage 40 . Butyric acid can enhance Tregs over in ammatory Th cells, including Th17 cells 41 . In our study, we found that sodium butyrate treatment can regulate the Th17/Treg imbalance and alleviate lymphocyte in ltration in HT mice.…”

Section: Discussionmentioning

confidence: 99%

Effects of iodine intake on gut microbiota community and metabolites: interactions between gut dysbiosis and Hashimoto thyroiditis

Wang,

Gong,

Meng

et al. 2023

Preprint

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Hashimoto thyroiditis (HT) is an organ-specific autoimmune disease associated with iodine intake. Increasing evidence suggests that the gut microbiota plays an important role between the gut and thyroid in HT pathogenesis, which is known as the microbiota-gut-thyroid axis. However, the mechanism by which iodine intake alters the microbiota and causes HT remains unclear. Therefore, this study investigated the mechanisms by which iodine intake influences gut dysbiosis and HT. We recruited 23 patients with HT and 25 healthy individuals to investigate alterations in the gut microbiota composition and metabolic characteristics. Furthermore, we established a spontaneously developed thyroiditis mouse model using NOD.H-2h4 mice underlying the influence of iodine intake on HT progression. The butanoate metabolism significantly differed beween these two groups according to the enrichment results, and butyric acid were significantly decreased in patients with HT compared with those healthy individuales. Gut dysbiosis contributes to TH17/Treg imbalance through a pathway regulated by the reduction of butyric acid. We demonstrated that excessive iodine intake significantly altered the composition of the intestinal flora, leading to gut dysbiosis and metabolic changes via the microbiota-gut-thyroid axis.

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Section: Discussionmentioning

confidence: 99%

Effects of iodine intake on gut microbiota community and metabolites: interactions between gut dysbiosis and Hashimoto thyroiditis

Wang,

Gong,

Meng

et al. 2023

Preprint

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“…Additionally, several studies have demonstrated that SCFAs can enhance glucose metabolism in adipose, muscle, and liver tissues, thus promoting body homeostasis [63]. Moreover, SCFAs have anti-inflammatory properties and can reduce mucosal and chronic organismal inflammation by inhibiting pro-inflammatory cytokines and promoting the secretion of anti-inflammatory cytokines [64]. These properties make SCFAs a promising therapeutic agent for inflammatory diseases, including diabetes.…”

Section: Short-chain Fatty Acidsmentioning

confidence: 99%

A Metabolite Perspective on the Involvement of the Gut Microbiota in Type 2 Diabetes

Fu,

Li,

Xiao

et al. 2023

IJMS

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Type 2 diabetes (T2D) is a commonly diagnosed condition that has been extensively studied. The composition and activity of gut microbes, as well as the metabolites they produce (such as short-chain fatty acids, lipopolysaccharides, trimethylamine N-oxide, and bile acids) can significantly impact diabetes development. Treatment options, including medication, can enhance the gut microbiome and its metabolites, and even reverse intestinal epithelial dysfunction. Both animal and human studies have demonstrated the role of microbiota metabolites in influencing diabetes, as well as their complex chemical interactions with signaling molecules. This article focuses on the importance of microbiota metabolites in type 2 diabetes and provides an overview of various pharmacological and dietary components that can serve as therapeutic tools for reducing the risk of developing diabetes. A deeper understanding of the link between gut microbial metabolites and T2D will enhance our knowledge of the disease and may offer new treatment approaches. Although many animal studies have investigated the palliative and attenuating effects of gut microbial metabolites on T2D, few have established a complete cure. Therefore, conducting more systematic studies in the future is necessary.

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“…Butyrate increased the expression of Treg-associated FoxP3 in a concentration-dependent manner and enhanced the differentiation of T cells into regulatory T (Treg) cells over inflammatory T helper (Th) cells, including Th17 cells (McBride et al . 2022 ). Mice that were fed butyrylated high-amylose maize starch, which was formed by the treatment of starch with butyric anhydride, showed an increased differentiation of Treg cells from the colon lamina propria and in the number of IL-10 producing Treg cells as compared to animals fed a control diet.…”

Section: Epigenetic Effects Of Scfas On Cells Of the Immune Systemmentioning

confidence: 99%

Epigenetic effects of short-chain fatty acids from the large intestine on host cells

Stein

Riber

2023

microLife

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Adult humans harbor at least as many microbial cells as eukaryotic ones. The largest compartment of this diverse microbial population, the gut microbiota, encompasses the collection of bacteria, archaea, viruses, and eukaryotic organisms that populate the gastrointestinal tract, and represents a complex and dynamic ecosystem that has been increasingly implicated in health and disease. The gut microbiota carries ∼100-to-150-times more genes than the human genome and is intimately involved in development, homeostasis, and disease. Of the several microbial metabolites that have been studied, short-chain fatty acids emerge as a group of molecules that shape gene expression in several types of eukaryotic cells by multiple mechanisms, which include changing histone acetylation, inducing DNA methylation, or through microRNA-mediated signaling. Butyric acid, one of the most extensively studied short-chain fatty acids, reaches higher concentrations in the colonic lumen, where it can be used as fuel by healthy colonocytes, than in the colonic crypts, where stem cells reside. In colon cancer cells, which preferentially metabolize glucose by glycolysis, butyric acid induces epigenetic modifications, leading to cell cycle progression inhibition and apoptosis. The lower butyrate concentration in the colonic crypts epigenetically inhibits negative regulators of the cell cycle, pointing towards the importance of the crypts in providing a protective niche for stem cells. A better understanding of the interface between the gut microbiota metabolites and epigenetic changes in eukaryotic cells promises to unravel in more detail processes that occur physiologically and, as part of disease, help develop novel biomarkers, and identify new therapeutic modalities.

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Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro

Cited by 13 publications

References 55 publications

Effects of iodine intake on gut microbiota community and metabolites: interactions between gut dysbiosis and Hashimoto thyroiditis

Effects of iodine intake on gut microbiota community and metabolites: interactions between gut dysbiosis and Hashimoto thyroiditis

A Metabolite Perspective on the Involvement of the Gut Microbiota in Type 2 Diabetes

Epigenetic effects of short-chain fatty acids from the large intestine on host cells

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