Short-chain aliphatic amines in human urine: a mathematical examination of metabolic interrelationships

Mitchell, Stephen C.; Bollard, Mary E.; Zhang, AiQin

doi:10.1016/j.metabol.2006.08.017

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…These 3 methylamines have been shown to be metabolically related (Mitchell et al 2007). Dimethylamine is a metabolic byproduct of dimethylarginine (involved in nitric oxide synthesis), and has been reported to be elevated in patients with hypertension and cardiac dysfunction (Achan et al 2003;Böger 2005), but decreased in plasma and urine of exercise-trained patients (Schlager et al 2011;Serre et al 2011).…”

Section: Discussionmentioning

confidence: 99%

¹H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D₃supplementation in older men

Sheedy

Gooley

Nahid

et al. 2014

Appl. Physiol. Nutr. Metab.

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The musculoskeletal benefits of calcium and vitamin-D3 supplementation and exercise have been extensively studied, but the effect on metabolism remains contentious. Urine samples were analyzed by (1)H-NMR spectroscopy from participants recruited for an 18-month, randomized controlled trial of a multi-component exercise program and calcium and vitamin-D3 fortified milk consumption. It was shown previously that no increase in musculoskeletal composition was observed for participants assigned to the calcium and vitamin-D3 intervention, but exercise resulted in increased bone mineral density, total lean body mass, and muscle strength. Retrospective metabolomics analysis of urine samples from patients involved in this study revealed no distinct changes in the urinary metabolome in response to the calcium and vitamin-D3 intervention, but significant changes followed the exercise intervention, notably a reduction in creatinine and an increase in choline, guanidinoacetate, and hypoxanthine (p < 0.001, fold change > 1.5). These metabolites are intrinsically involved in anaerobic ATP synthesis, intracellular buffering, and methyl-balance regulation. The exercise intervention had a marked effect on the urine metabolome and markers of muscle turnover but none of these metabolites were obvious markers of bone turnover. Measurement of specific urinary exercise biomarkers may provide a basis for monitoring performance and metabolic response to exercise regimes.

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Section: Discussionmentioning

confidence: 99%

¹H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D₃supplementation in older men

Sheedy

Gooley

Nahid

et al. 2014

Appl. Physiol. Nutr. Metab.

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“…Fish flavour is derived from volatile compounds like trimethylamine, which may stimulate the odour receptors (Methven et al, 2007). Recently, Mitchell et al (2007) identified a unique constituent, trimethylamine, in human urine and reported that it may act as a pheromone.…”

Section: Discussionmentioning

confidence: 99%

Detection of oestrous-related odour in bovine (Bos taurus) saliva: bioassay of identified compounds

Sankar

Archunan

Habara

2007

Animal

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The present study was designed to identify the volatile constituents across the oestrous cycle of bovine in order to detect oestrous-specific chemical signal. The bovine saliva was extracted with diethyl ether (1 : 1 ratio, v/v) and analysed by gas chromatography-linked mass spectrometry. Numerous compounds were identified during oestrous cycle of bovine saliva. Among these, the compounds, namely, trimethylamine, acetic acid, phenol 4-propyl, pentanoic acid and propionic acid were specific to oestrous stage. The behaviour assay revealed that the compound, trimethylamine, is involved in attracting the male animal. The result concludes that the trimethylamine is considered as a putative oestrous-specific salivary chemo-signal in the bovine.

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“…1) [115]. This decrease in flavin monooxygenase mediated trimethylamine N-oxidation around menstruation has recently been confirmed and it has been suggested that certain allelic variants of this enzyme may be more susceptible to this phenomenon [116,117,118]. Although trimethylamine is a dietary xenobiotic, flavincontaining monooxygenase, in particular FMO3, is known to be involved in the metabolism of many drugs and therapeutic agents especially at nitrogen and sulphur centers.…”

Section: Other Phase I Reactionsmentioning

confidence: 95%

The Menstrual Cycle and Drug Metabolism

Mitchell¹,

Smith²,

Waring³

2009

CDM

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Within the field of drug metabolism, when addressing quantitative aspects, an average value is traditionally quoted, commonly the arithmetic mean with perhaps an indication of spread. Better still a range of values may be given, thereby acknowledging that various factors may precipitate differences between individuals. A single subject, however, usually only merits a single value. Nevertheless, events such as an acute illness or concurrent drug therapy serve to alert that this value may change substantially over a relatively short time-period, although any potential effects of naturally occurring phenomena, such as the female menstrual cycle, are often overlooked or disregarded. Are the biochemical and physiological changes that occur during the menstrual cycle able to influence xenobiotic metabolism? Is the idea of a stable and unwavering baseline within a single healthy individual flawed? Is it time to reassess our thinking with regards to such aspects? This brief review explores these issues and examines information available within the literature for evidence of potential influences of menstrual cycle events upon drug metabolism, defined as the actual chemical alteration of the parent molecule into another chemical species.

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Short-chain aliphatic amines in human urine: a mathematical examination of metabolic interrelationships

Cited by 6 publications

References 33 publications

¹H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D₃supplementation in older men

¹H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D₃supplementation in older men

Detection of oestrous-related odour in bovine (Bos taurus) saliva: bioassay of identified compounds

The Menstrual Cycle and Drug Metabolism

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Short-chain aliphatic amines in human urine: a mathematical examination of metabolic interrelationships

Cited by 6 publications

References 33 publications

1H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D3supplementation in older men

1H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D3supplementation in older men

Detection of oestrous-related odour in bovine (Bos taurus) saliva: bioassay of identified compounds

The Menstrual Cycle and Drug Metabolism

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Product

Resources

About

¹H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D₃supplementation in older men

¹H-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium–vitamin-D₃supplementation in older men