Short-bowel syndrome

Westergaard, Henrik

doi:10.1007/s11938-000-0060-5

Cited by 9 publications

(3 citation statements)

References 30 publications

(16 reference statements)

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“…Intestinal adaptation is defined as a process of progressive recovery from intestinal failure after bowel resection and includes morphologic and functional changes (11,12) . Morphologic changes include lengthening of the villi and deepening of the crypts, increased enterocyte proliferation, and increased migration of enterocytes along the villi.…”

Section: Discussionmentioning

confidence: 99%

“…The result of these actions helps to reshape the crypt-villus structures to more elongated and functionally active units. The regulation of the balance between cell production and cell loss through apoptosis after bowel resection is complex and the precise factors that guide this adaptive process remain unclear (11,12). In particular, it is not clear where many of these trophic factors act along the crypt-villus axis.…”

Section: Introductionmentioning

confidence: 99%

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Leptin Affects Intestinal Epithelial Cell Turnover in Correlation With Leptin Receptor Expression Along the Villus-Crypt Axis After Massive Small Bowel Resection in a Rat

et al. 2009

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ABSTRACT:In this study, we examine the responsiveness of intestinal epithelial cell turnover to leptin (LEP) in correlation with leptin receptor (LEPr) expression along the villus-crypt axis in a rat with short bowel syndrome (SBS). Adult rats underwent either a 75% intestinal resection or a transection. SBS-LEP rats underwent bowel resection and were treated with LEP starting from the fourth postoperative day. Parameters of intestinal adaptation, enterocyte proliferation, and enterocyte apoptosis were determined at sacrifice. RT-PCR technique was used to determine Bax and Bcl-2 gene expression in ileal mucosa. Villus tips, lateral villi, and crypts were separated using laser capture microdissection. LEPr expression for each compartment was assessed by quantitative real-time PCR (Taqman). Treatment with LEP significantly stimulated all parameters of adaptation. LEPr expression in crypts significantly increased in SBS rats (vs Sham rats) and was accompanied by a significant increase in enterocyte proliferation and decreased apoptosis after LEP administration. A significant increase in LEPr expression at the tip of the villus in SBS rats was accompanied by decreased cell apoptosis. In conclusion LEP accelerated enterocyte turnover and stimulated intestinal adaptation. The effect of LEP on enterocyte proliferation and enterocyte apoptosis correlated with receptor expression along the villus-crypt axis. (Pediatr Res 66: 648-653, 2009)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leptin Affects Intestinal Epithelial Cell Turnover in Correlation With Leptin Receptor Expression Along the Villus-Crypt Axis After Massive Small Bowel Resection in a Rat

et al. 2009

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“…(JPGN 2013;57: 562-569) S hort bowel syndrome (SBS) may occur with congenital anomalies or massive small bowel resection (SBR). After SBR, the residual intestine undergoes a series of adaptive processes that result in a significant increase in intestinal absorptive surface area and establishes nutritional homeostasis (1,2); however, the mechanism of this adaptation process is still not well understood, although a number of nutritive and non-nutritive factors have been reported as potential mediators of this compensatory response (3)(4)(5). Adaptation in SBS consists not only of an increase in intestinal epithelial cell (IEC) proliferation, but also an increase in rates of EC apoptosis (6).…”

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confidence: 99%