Short Bowel Syndrome

Laparoscopic ileocecal resection for bowel endometriosis

“…In fact although some women may remain asymptomatic, most of them will develop a variety of endometriosis-related symptoms of gastrointestinal dysfunction, including dyschezia, anal pain, rectal bleeding, and, rarely, bowel occlusion [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. In the majority of patients, these symptoms are related to the presence of deep endometriosis involving the rectum or rectosigmoid junction [5,8,12,22].…”

“…removal of bowel endometriosis usually leads to a persistent improvement of symptoms, quality of life, and fertility with a low recurrence rate [12][13][14][15][16][17][18][19][20][21][22][23][24]. Ileal endometriosis is a very rare entity, with an incidence between 1 and 7% [20].…”

Inhibition of ACE activity contributes to the intestinal structural compensation in a massive intestinal resection rat model

“…After massive small bowel resection (SBR), the residual intestine undergoes a series of adaptive processes resulting in a significant increase in intestinal absorptive surface area [1,2]. In addition to an increase in functional absorption, adaptation also consists of an increase in villus length and crypt depth, and an increased number of microvilli [1,2].…”

“…After massive small bowel resection (SBR), the residual intestine undergoes a series of adaptive processes resulting in a significant increase in intestinal absorptive surface area [1,2]. In addition to an increase in functional absorption, adaptation also consists of an increase in villus length and crypt depth, and an increased number of microvilli [1,2]. This compensatory role is to rehabilitate patients with SBS in the initial stages and to ensure improved adaptability of the remaining bowel, including structural and functional compensation which is the key to prevent intestinal failure.…”

Short-bowel syndrome - surgical treatment with long-term benefit?

“…Maximum adaptation can only be reached when early enteral nutrition acts as a potent stimulator of mucosal growth [25]. The period of adaptation typically lasts for about 1 year in adults and up to 4 years in children [26,27]. It is commonly believed that patients will remain on TPN if enteral autonomy has not been regained by that time.…”