Short Biography Of Michel Van Esbroeck

Esbroeck, Michel van

doi:10.31826/9781463216306-002

Cited by 5 publications

(5 citation statements)

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“…For this a demagnetization field B dem = 0.020(4) T is calculated. The foils used by the Oxford group for the measurements with 67 Cu, 69 Cu and 71 Cu had an initial thickness of 250 µm [45]. They were first polished with sand paper with CAMI (Coated Abrasive Manufacturers Institute) grit designation 600 (i.e.…”

Section: Demagnetization Fieldmentioning

confidence: 99%

Hyperfine field and hyperfine anomalies of copper impurities in iron

Golovko¹,

Wauters²,

Breitenfeldt³

et al. 2011

Phys. Rev. C

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A new value for the hyperfine magnetic field of copper impurities in iron is obtained by combining resonance frequencies from experiments involving beta-NMR on oriented nuclei on Cu-59, Cu-69, and Cu-71 with magnetic moment values from collinear laser spectroscopy measurements on these isotopes. The resulting value, i.e., B-hf(CuFe) = -21.794(10) T, is in agreement with the value adopted until now but is an order of magnitude more precise. It is consistent with predictions from ab initio calculations. Comparing the hyperfine field values obtained for the individual isotopes, the hyperfine anomalies in Fe were determined to be (59)Delta(69) = 0.15(9)% and (71)Delta(69) = 0.07(11)%

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Section: Demagnetization Fieldmentioning

confidence: 99%

Hyperfine field and hyperfine anomalies of copper impurities in iron

Golovko¹,

Wauters²,

Breitenfeldt³

et al. 2011

Phys. Rev. C

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“…Searchable Comments ---ABHD6 has also been shown to accept diacylglycerol as a substrate, thereby producing 2-acylglycerols [697]. WWL70 has been suggested to have activity at oxidative metabolic pathways independent of ABHD6 [668].…”

Section: Further Reading On Endocannabinoid Turnovermentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

Alexander

Fabbro

Kelly

et al. 2021

British J Pharmacology

369

288

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The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15542. Enzymes are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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“…16 ABPs for disease-related enzymes can contribute to not only development of drugs and diagnostics but also understanding of the dynamics of enzymes. 17,18 Although many human enzymes, including cysteine and serine proteases, have been characterized by specific ABPs designed from reliable peptidebased irreversible inhibitors, 19−21 exogenous enzymes from pathogens have rarely been targeted. Bogyo et al developed ABPs for falcipain 1 from Plasmodium falciparum, a malariacausing parasite, and found that the peak of falcipain 1 activity differs from the previously reported falcipain 1 mRNA level.…”

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confidence: 99%

Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead

Yamauchi,

Konno,

Omura

et al. 2024

ACS Chem. Biol.

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The 3CL protease (3CLpro) is a viral cysteine protease of SARS-CoV-2 and is responsible for the main processing of the viral polyproteins involved in viral replication and proliferation. Despite the importance of 3CLpro as a drug target, the intracellular dynamics of active 3CLpro, including its expression and subcellular localization in SARS-CoV-2-infected cells, are poorly understood. Herein, we report an activity-based probe (ABP) with a clickable alkyne and an irreversible warhead for the SARS-CoV-2 3CL protease. We designed and synthesized two ABPs that contain a chloromethyl ketone (probe 2) or 2,6dichlorobenzoyloxymethyl ketone (probe 3) reactive group at the P1′ site. Labeling of recombinant 3CLpro by the ABPs in the purified and proteome systems revealed that probe 3 displayed ligand-directed and selective labeling against 3CLpro. Labeling of transiently expressed active 3CLpro in COS-7 cells also validated the good target selectivity of probe 3 for 3CLpro. We finally demonstrated that endogenously expressed 3CLpro in SARS-CoV-2-infected cells can be detected by fluorescence microscopy imaging using probe 3, suggesting that active 3CLpro at 5 h postinfection is localized in the juxtanuclear region. To the best of our knowledge, this is the first report investigating the subcellular localization of active 3CLpro by using ABPs. We believe that probe 3 will be a useful chemical tool for acquiring important biological knowledge of active 3CLpro in SARS-CoV-2-infected cells.

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Short Biography Of Michel Van Esbroeck

Cited by 5 publications

References 0 publications

Hyperfine field and hyperfine anomalies of copper impurities in iron

Hyperfine field and hyperfine anomalies of copper impurities in iron

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead

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