Short arm of chromosome 1 aberration recurrently found in pigmented villonodular synovitis

Ohjimi, Yuko; Iwasaki, Hiroshi; Ishiguro, Masako; Kaneko, Yasuhiko; Tashiro, Himiko; Emoto, Gen; Ogata, Kosuke; Kikuchi, Masahiro

doi:10.1016/0165-4608(96)00064-7

Cited by 53 publications

(30 citation statements)

References 14 publications

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“…The most frequent chromosome changes, among the ten cases reported in the literature, is an increase of chromosomes 5 or 7. Moreover, chromosome regions involved more than once were 1p10-p34 in four cases, 5q31-35 in two cases and 15q in two cases [24]. The presence of an extra chromosome 7 is correlated with an increase of proliferative activity in several tumours [14,16].…”

Section: Discussionmentioning

confidence: 92%

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Rosa

Galli

Fadda

et al. 2000

International Orthopaedics

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Proliferating cell nuclear antigen (PCNA) is one of the cell cycle-related proteins directly involved in DNA synthesis. It is a marker of cellular proliferation and has been shown to correlate with ploidy and proliferative activity of cells. Its expression has been used to estimate the growth fraction of human cancer and its prognostic value. Pigmented villo-nodular synovitis (PVNS) is characterised by a nodular lesion in the paratendinous synovial tissue or, less frequently, in a joint. Whether PVNS is a neoplastic or inflammatory lesion remains controversial. We have studied immunohistochemical PCNA expression with pc10 monoclonal antibody in 16 paraffin sections, in 16 cases of localised PVNS, or giant cell tumour of tendon sheath. We have found significant correlation between the size of the lesions and PCNA-LI (labelling index).Résumé L'antigène nucleaire de prolifération cellulaire (PCNA) est une des proteines du cycle cellulaire et il est impliqué directement dans la synthèse du DNA. Il s'agit certainement d'un indicateur de prolifération cellulaire. Son expression a été employé pour évaluer l'index de prolifération de la tumeur humaine et son valeur au point de vue pronostique. La synovite villo-nodulaire pigmentée (PVNS) est caractérisée par une lésion nodulaire plus fréquente dans les localisations tendineuses que dans les articulations. S'il s'agit d'un processus néoplasique ou d'une lésion inflammatoire reste controversée. Nous avons étudiés l'expression immunohistochimique du PCNA avec l'anticorps monoclonal PC10 en 16 lames paraffinés relatives à 16 synovites villo-nodulaires pigmentées localisées ou tumeurs à cellules geantes des gaines tendineuses. Nous avons trouvés une corrélation significative entre les dimensions des lésions nodulaires et le PCNA labelling index (PCNA-LI).

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Section: Discussionmentioning

confidence: 92%

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Rosa

Galli

Fadda

et al. 2000

International Orthopaedics

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“…TGCT has been analyzed by G-banding, and a breakpoint in the region 1p11-13 has been observed in the majority of cases (10)(11)(12)(13)(14)(15). FISH probe analysis showed that the breakpoints clustered to one region located in 1p13.2 in 18 of 21 cases (12).…”

Section: Resultsmentioning

confidence: 99%

“…They were suggested to be reactive by Jaffe (9) in the initial classification of TGCT and related lesions. There have subsequently been reports of clonal cytogenetic abnormalities, most commonly involving 1p11, in TGCT, supporting a neoplastic origin with activation of a growth-promoting gene through a balanced translocation (10)(11)(12)(13)(14)(15). The finding that the cells of TGCT are polyclonal, by analysis of X-chromosome inactivation (16), and the identification of similar chromosomal translocations in hemorrhagic synovitis or rheumatoid synovitis (11) has cast doubt on the neoplastic nature of TGCT.…”

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confidence: 99%

A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells

West

Rubin

Miller

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

459

385

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Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations. Chromosomal translocations involving chromosome 1p13 have been reported in both TGCT and PVNS. We confirm that translocations involving 1p13 are present in a majority of cases of TGCT and PVNS and show that CSF1 is the gene at the chromosome 1p13 breakpoint. In some cases of both TGCT and PVNS, CSF1 is fused to COL6A3 (2q35). The CSF1 translocations result in overexpression of CSF1. In cases of TGCT and PVNS carrying this translocation, it is present in a minority of the intratumoral cells, leading to CSF1 expression only in these cells, whereas the majority of cells express CSF1R but not CSF1, suggesting a tumor-landscaping effect with aberrant CSF1 expression in the neoplastic cells, leading to the abnormal accumulation of nonneoplastic cells that form a tumorous mass.pigmented villonodular synovitis ͉ receptor tyrosine kinase ͉ macrophage ͉ COL6A3

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“…Open surgical synovectomy causes stiffness and pain and has a long recovery time, mainly after procedures involving the knee joint. However, the relapse rates of both approaches are reported to be relatively high, ranging between 8% and 46% [10,14]. As a result, surgical treatment of large joints alone without adjuvant therapy has been considered unsatisfactory.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee with Combined Surgical and Radiosynovectomy

Nassar

Bassiony

Elghazaly

2009

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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Treatment of extensive diffuse pigmented villonodular synovitis (PVNS) of large joints by isolated surgical resection is unsatisfactory, with high rates of local recurrence. Post-synovectomy adjuvant treatment with external beam radiation therapy or intra-articular injection of radioactive material as yttrium-90 ( 90 Y) yielded better results. Between January 2005 and January 2007, 12 patients (eight men and four women aged 19-49 years) with extensive diffuse PVNS of the knee were treated. All patients had an adjuvant postoperative external beam radiation therapy (2,600-3,000 cGy) conventionally fractionated 200 cGy/fraction, five fractions/ week, 6-8 weeks after surgery. Mean follow-up time was 27 months (range from 20 to 36 months). All patients were followed up using clinical assessment, magnetic resonance imaging, and plain X-ray. In all patients, neither evidence of disease recurrence nor progression of bone or articular destruction was noted. No complications were noticed after surgery or after post-operative external beam radiation therapy. A combination of debulking surgery using anterior and posterior approach with adjuvant post-operative external beam radiation therapy for extensive diffuse PVNS of the knee joint is a reliable treatment method, with good results in regard to the incidence of local recurrence and functional outcome.

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Short arm of chromosome 1 aberration recurrently found in pigmented villonodular synovitis

Cited by 53 publications

References 14 publications

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules

A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells

Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee with Combined Surgical and Radiosynovectomy

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