Short and oral antimicrobial therapy for diabetic foot infection: a narrative review of current knowledge

Maurer, Steven M.; Hepp, Zehra S.; McCallin, Shawna; Waibel, Felix W A; Romero, Federico C.; Zorman, Yılmaz; Lipsky, Benjamin A.; Uçkay, İlker

doi:10.5194/jbji-7-61-2022

Cited by 8 publications

(6 citation statements)

References 57 publications

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“…We examined risk factors of osteomyelitis in patients with fractures of the upper and lower extremities. Our findings are consistent with the results of studies that have associated a history of diabetes or stress-induced hyperglycemia with infectious complications including osteomyelitis [ 13 , 14 , 15 ]. Patients with diabetes tend to have impaired bone regeneration [ 16 , 17 ].…”

Section: Discussionsupporting

confidence: 92%

Risk Factors for Postoperative Osteomyelitis among Patients after Bone Fracture: A Matched Case–Control Study

Slyamova

Gusmanov

Batpenov³

et al. 2022

JCM

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The healthcare burden of osteomyelitis is increasing. Postoperative and posttraumatic osteomyelitis account for 80% of all cases of osteomyelitis. The aim of this study was to find risk factors for postoperative osteomyelitis in Kazakhstan. We included 245 patients admitted to the National Scientific Center of Traumatology and Orthopedics from 2018 to 2020. Cases were matched with controls in a 1:4 ratio. Exact matching was performed by gender, ICD-10, and ICD-9 codes. The main variables included socio-demographics, diagnosis at admission, characteristics of fractures, comorbidities, complications, hospitalization milestones, and osteomyelitis characteristics. Descriptive analyses, along with bivariate analysis and multivariate conditional logistic regression, were performed. Open fracture (adjOR = 6.25; 95%CI 1.64–23.79), the presence of complications of initial fracture (adjOR = 3.46, 95%CI 1.13–10.56), comminuted fracture form (adjOR = 1.87; 95%CI 0.73–4.75), a positive history of diabetes or blood glucose >7 g/L (adjOR = 4.25; 95%CI 1.26–14.3), incision or wound length of more than 10 cm (adjOR = 6.53; 95%CI 1.1–38.6), additional implanted medical item (adjOR = 1.23; 95% CI 1.1–1.47), and unemployment or being retired (adjOR = 4.21; 95%CI 1.74–10.18) were found to be significant predictors of postoperative osteomyelitis. Almost all our findings are concordant with previous studies, except for the type of fracture. Different authors report conflicting results on the latter potential risk factor. Therefore, prospective studies on this issue are required.

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Section: Discussionsupporting

confidence: 92%

Risk Factors for Postoperative Osteomyelitis among Patients after Bone Fracture: A Matched Case–Control Study

Slyamova

Gusmanov

Batpenov³

et al. 2022

JCM

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“… 99 Researchers have suggested that the maximum duration of antibiotic therapy should be no more than 4 to 6 weeks. 100 …”

Section: Discussionmentioning

confidence: 99%

“…For diabetic foot osteomyelitis treatment, using antibiotics that penetrate the bone and are active against biofilms is important 99 . Researchers have suggested that the maximum duration of antibiotic therapy should be no more than 4 to 6 weeks 100 …”

Section: Discussionmentioning

confidence: 99%

A scientometrics analysis and visualisation of diabetic foot research from 1955 to 2022

Shen

Chen

Feng

et al. 2022

International Wound Journal

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Diabetic foot (DF) has become a serious health problem in modern society, and it has been a hotspot of research for a long time. However, little scientometric analysis has been carried out on DF. In the present study, we analysed 8633 literature reports on DF in the Web of Science Core Collection from database inception until April 23, 2022. VOSviewer (Centre for Science and Technology Studies at Leiden University, Leiden, the Netherlands) and CiteSpace (College of Computing and Informatics, Drexel University, Philadelphia, United States) were employed to address high‐impact countries and institutions, journals, references, research hotspots, and key research fields in DF research. Our analysis findings indicated that publications on DF have increased markedly since 2016 and were primarily published in the United States of America. The recent studies focus on the amniotic membrane, foot ulcers, osteomyelitis, and diabetic wound healing. The five keyword clusters, which included DF ulcer and wound healing therapies, management and guidelines, neuropathy and plantar pressure, amputation and ischemia, and DF infection and osteomyelitis, are helpful for enhancing prevention, standardising treatment, avoiding complications, and improving prognosis. These findings indicated a method for future therapies and research in DF.

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“…Osteomyelitis is a specific podiatric problem typically resolved using long-term ATB therapy lasting 6-8 weeks or longer in the case of conservative management ( 12 ). Recently, however, there is a trend to reduce ATB treatment in the case of osteomyelitis, with a recommended maximum duration of 4-6 weeks or even shorter in selected cases ( 13 ).…”

Section: Diabetic Footmentioning

confidence: 99%

Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review

et al. 2023

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Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy can be easily verified using triplex ultrasound, ankle-brachial/toe-brachial index examination, or transcutaneous oxygen pressure. However, the success of infection treatment is difficult to establish in patients with diabetic foot. Intravenous systemic antibiotics are recommended for the treatment of infectious complications in patients with moderate or serious stages of infection. Antibiotic therapy should be initiated promptly and aggressively to achieve sufficient serum and peripheral antibiotic concentrations. Antibiotic serum levels are easily evaluated by pharmacokinetic assessment. However, antibiotic concentrations in peripheral tissues, especially in diabetic foot, are not routinely detectable. This review describes microdialysis techniques that have shown promise in determining antibiotic levels in the surroundings of diabetic foot lesions.

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Short and oral antimicrobial therapy for diabetic foot infection: a narrative review of current knowledge

Cited by 8 publications

References 57 publications

Risk Factors for Postoperative Osteomyelitis among Patients after Bone Fracture: A Matched Case–Control Study

Risk Factors for Postoperative Osteomyelitis among Patients after Bone Fracture: A Matched Case–Control Study

A scientometrics analysis and visualisation of diabetic foot research from 1955 to 2022

Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review

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