Short- and medium-term reproducibility of gastric emptying of a solid meal determined by a low dose of¹³C-octanoic acid and nondispersive isotope-selective infrared spectrometry

Abstract

The low-cost modification of the breath test involving a lower dose of 13C-octanoic acid and NDIRS, renders good short- and medium-term reproducibility, as well as sensitivity of the measurement of gastric emptying of solids.

13C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations

“…Breath tests performed with the use of stable isotopes, such as 13 C, cannot be considered an exception in this respect, especially because during the past decade their clinical use has been constantly growing [24,34,35] . An increase in the number of relevant scientific papers indicates that, from among the tests dedicated to assess the activity of cytochrome P450, known as the microsomal breath tests, the 13 C-MBT has lately taken the lead.…”

Extracirculatory effects of noise of various frequency spectra in humans-effect of pink and blue noise on gastric myoelectrical activity and gastrointestinal passage of nutrients

“…In our laboratory we provided proof of reproducibility of every of the methods used in the current study (Jonderko et al, 2003;Jonderko et al, 2005b;Kasicka-Jonderko et al, 2005;KasickaJonderko et al, 2006b). Based on a repeat examinations model, it was shown that the 13 Cacetate breath test is capable of detecting a 6 min difference in T½ of an acaloric load, whereas the 13 C-octanoic acid breath test offered detectability of a 10 min difference in T½ of a solid caloric test meal with twelve paired studies at P=0.05 level, two-tailed (Kasicka- Jonderko et al, 2005;Kasicka-Jonderko et al, 2006b). With a 10 g lactulose dose and a 5 ppm expected H2 increment over the baseline, a difference in the orocecal transit time of 19 min will be detected with a hydrogen breath test in a trial involving 12 paired examination (Jonderko et al, 2003).…”

“…scintigraphy, ultrasonography, magnetic resonance imaging), the T_Lag will be nowadays more and more willingly replaced by a term 'time to reach the maximum of the momentary 13 CO2 excretion' which is the revised representation of what the T_Lag derived mathematically from the function fitted to a 13 CO2 excretion curve actually is. We discussed this problem in more detail elsewhere (Kasicka-Jonderko et al, 2006b). Nevertheless, putting aside this remark, we decided anyway to make the readership familiar with the results of the gastric emptying measurements conveyed by both the parameters recognized historically to reflect quantitatively the gastric emptying determined by the 13 CO2 breath tests.…”

“…• a semiliquid (378 kcal; 10.8 g proteins, 10.0 g fat, and 61. strawberry jam (Kasicka-Jonderko et al, 2006b); a drink of 200 ml still mineral water was allowed to facilitate the eating. During the preparation procedure 75 µL (68 mg) of 13 Coctanoic acid (INC610P, Euriso-Top, France) was first added to the raw egg yolks, then 10 g lactulose powder (Duphalac Dry, Solway Pharmaceuticals B.V., Weesp, The Netherlands) was mixed into the raw pancake dough.…”

Effect of Helicobacter pylori eradication on gastric emptying and symptoms in patients with dyspepsia

“…They are harmless, noninvasive, and easy to perform, even in elderly or disabled patients. Accordingly, repeated GE studies with breath tests involving the stable 13 C isotope are entirely acceptable even in children and pregnant women [7][8][9].…”