Short and Long Term Physiological and Neurochemical Adaptations to Social Conflict

Miczek, Klaus A.; Thompson, Michael L.; Tornatzky, Walter

doi:10.1007/978-94-009-1990-7_2

Cited by 23 publications

(19 citation statements)

References 63 publications

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“…The action of agomelatine in socially defeated animals as shown in sham-operated animals is not found in SCNlesioned animals. According to the suggestion that social defeat induces a state of stress and anxiety (Koolhaas et al, 1995;Miczek et al, 1990;Koolhaas et al, 1997), the present study shows that agomelatine might have an anxiolytic or anti-stress action that requires the integrity of the SCN.…”

Section: Discussionmentioning

confidence: 48%

“…Social defeat by an aggressive male conspecific is a natural stressor which is known to induce a state of stress and anxiety as expressed by more immobility and less exploration (Koolhaas et al, 1995;Miczek et al, 1990;Koolhaas et al, 1997). Such a defeat is known to induce acute and strong effects on cardiovascular and neuroendocrine activation, hyperthermia and behaviour (Miczek et al, 1990;Bohus et al, 1987;Tornatzky and Miczek, 1994), and longer lasting effects on behavioural and physiological parameters (Koolhaas et al, 1990;Miczek et al, 1990;Meerlo et al, 1996a,b). Social defeat also causes a variety of alterations in the daily rhythms, i.e., a sharp subsequent reduction in the amplitude of the daily temperature and activity rhythm, which lasted for at least 4 days (Meerlo et al, 1996b;Meerlo et al, 1997Meerlo et al, , 2002.…”

Section: Introductionmentioning

confidence: 99%

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Anxiolytic-like action of the antidepressant agomelatine (S 20098) after a social defeat requires the integrity of the SCN

Tuma

Strubbe

Mocaër

et al. 2005

European Neuropsychopharmacology

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In rats, social defeat by an aggressive opponent induces a state of anxiety, shown by a decrease in time spent on active explorative behaviour, an increase in immobility, a clear decrease in frequency of all active behavioural parameters (enhanced passivity). We tested the hypothesis whether acute or sub-chronic agomelatine would antagonize the negative consequences of a social defeat. As many chronobiological actions of melatonin and its receptor agonist agomelatine require the integrity of the suprachiasmatic nuclei (SCN), we examined whether the anxiolytic-like action of agomelatine 1 day after a social defeat is still present in SCN-lesioned rats. Sub-chronic administration of agomelatine caused a clear reduction of the social defeat induced behavioural consequences. A single agomelatine injection prior to the post-defeat test was less effective and a single melatonin injection was hardly effective. SCN lesion did not affect the anxiety reaction after a social defeat. Thus, sub-chronic agomelatine treatment or a single agomelatine injection reduced a state of anxiety and passivity caused by asocial defeat. The defeat-induced behavioural changes do not depend on the SCN but agomelatine showed its anxiolytic action only in sham-lesioned animals, which indicates that the anxiolytic-like action of agomelatine requires the integrity of the SCN. Mechanisms sustaining this activity are discussed.

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Anxiolytic-like action of the antidepressant agomelatine (S 20098) after a social defeat requires the integrity of the SCN

Tuma

Strubbe

Mocaër

et al. 2005

European Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…Moreover, the experience of defeat in a social conflict is a rather dramatic event associated with behavioral and physiological changes that can last for several days up to weeks after the conflict (Meerlo et al, 1996a,b;Miczek et al, 1990). Social defeat has also been found to have immediate effects on subsequent sleep: rats (Meerlo et al, 1997(Meerlo et al, , 2001a and mice (Meerlo and Turek, 2001) showed increased amounts of NREM sleep and/or increased NREM intensity, as reflected in elevated EEG SWA.…”

Section: Introductionmentioning

confidence: 95%

Deep sleep after social stress: NREM sleep slow-wave activity is enhanced in both winners and losers of a conflict

Kamphuis

Lancel

Koolhaas

et al. 2015

Brain, Behavior, and Immunity

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“…Similarly, a single social defeat produces robust activation of the HPA axis (Huhman et al, 1991; Koolhaas et al, 1997). The effects of repeated social defeat are more complex, as chronic social defeat has been shown to elevate basal glucocorticoid levels (Berton et al, 1998; Miczek et al, 1990), whereas chronic subordination in a group of rats leads to a blunted glucocorticoid response to a subsequent stressor in a subset of subordinates (Blanchard et al, 1995). Because of these behavioral and neuroendocrine changes, the behavioral paradigms described below have been argued to model MDD in humans.…”

Section: Animal Modelsmentioning

confidence: 99%

Overlapping neurobiology of learned helplessness and conditioned defeat: Implications for PTSD and mood disorders

2012

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Exposure to traumatic events can increase the risk for major depressive disorder (MDD) as well as posttraumatic stress disorder (PTSD), and pharmacological treatments for these disorders often involve the modulation of serotonergic (5-HT) systems. Several behavioral paradigms in rodents produce changes in behavior that resemble symptoms of MDD and these behavioral changes are sensitive to antidepressant treatments. Here we review two animal models in which MDD-like behavioral changes are elicited by exposure to an acute traumatic event during adulthood, learned helplessness (LH) and conditioned defeat. In LH, exposure of rats to inescapable, but not escapable, tailshock produces a constellation of behavioral changes that include deficits in fight/flight responding and enhanced anxiety-like behavior. In conditioned defeat, exposure of Syrian hamsters to a social defeat by a more aggressive animal leads to a loss of territorial aggression and an increase in submissive and defensive behaviors in subsequent encounters with non-aggressive conspecifics. Investigations into the neural substrates that control LH and conditioned defeat revealed that increased 5-HT activity in the dorsal raphe nucleus (DRN) is critical for both models. Other key brain regions that regulate the acquisition and/or expression of behavior in these two paradigms include the basolateral amygdala (BLA), central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST). In this review, we compare and contrast the role of each of these neural structures in mediating LH and conditioned defeat, and discuss the relevance of these data in developing a better understanding of the mechanisms underlying trauma-related depression.

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Short and Long Term Physiological and Neurochemical Adaptations to Social Conflict

Cited by 23 publications

References 63 publications

Anxiolytic-like action of the antidepressant agomelatine (S 20098) after a social defeat requires the integrity of the SCN

Anxiolytic-like action of the antidepressant agomelatine (S 20098) after a social defeat requires the integrity of the SCN

Deep sleep after social stress: NREM sleep slow-wave activity is enhanced in both winners and losers of a conflict

Overlapping neurobiology of learned helplessness and conditioned defeat: Implications for PTSD and mood disorders

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