Short and long-term outcomes of laparoscopic total gastrectomy for gastric cancer: A single-center experience (retrospective cohort study)

Huang, Chao Jie; Zhang, Ren Chao; Mou, Yi Ping; Zhou, Yu; Wang, Yuan Yu; Lü, Chao; Xu, Xiao

doi:10.1016/j.ijsu.2018.01.027

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…In our study, we found that in addition to the advantage in incision length, the LTG group had a faster postoperative recovery than that of the OTG group after NAT, which was mainly reflected in the postoperative hospital stay. Compared to a previous study[ 19 ], the mean postoperative hospital stay in the LTG group (11.5 d) was slightly longer, which was possibly attributed to the NAT. The number of dissected lymph nodes can be considered an indicator to evaluate the quality of gastrectomy, and is positively correlated with the prognosis of GC[ 34 - 36 ].…”

Section: Discussioncontrasting

confidence: 79%

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Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy: A propensity score matching analysis

Hu¹,

Ma²,

Xiong³

et al. 2022

WJGS

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BACKGROUND Laparoscopic total gastrectomy (LTG) has drawn increasing attention over the years. Although LTG has shown surgical benefits compared to open TG (OTG) in early stage gastric cancer (GC), little is known about the surgical and oncological outcomes of LTG for advanced GC following neoadjuvant therapy (NAT). AIM To compare the long- and short-term outcomes of advanced GC patients who underwent LTG vs OTG following NAT. METHODS Advanced GC patients who underwent TG following NAT between April 2011 and May 2018 at the Cancer Hospital of the Chinese Academy of Medical Sciences were enrolled and stratified into two groups: LTG and OTG. Propensity score matching analysis was performed at a 1:1 ratio to overcome possible bias. RESULTS In total, 185 patients were enrolled (LTG: 78; OTG: 109). Of these, 138 were paired after propensity score matching. After adjustment for propensity score matching, baseline parameters were similar between the two groups. Compared to OTG, LTG was associated with a significantly shorter length of hospital stay ( P = 0.012). The rates of R0 resection, lymph node harvest, and postoperative morbidity did not significantly differ between the two groups. Overall survival (OS) outcomes were comparable between the two groups. Pathological T and N stages were found to be independent risk factors for OS. CONCLUSION LTG can be a feasible method for advanced GC patients following NAT, as it appears to be associated with better short- and comparable long-term outcomes compared to OTG.

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Section: Discussioncontrasting

confidence: 79%

“…Recently, LTG has been widely performed in many high-volume hospitals and has gradually expanded the indications for surgery from EGC to AGC[ 19 , 20 ]. However, only one study to date has confirmed the non-inferiority of LTG compared to OTG after NAC in short-term outcomes[ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy: A propensity score matching analysis

Hu¹,

Ma²,

Xiong³

et al. 2022

WJGS

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“…On the other hand, in recent years, several studies[ 53 , 65 , 66 ] of laparoscopic total gastrectomy (LTG) in patients with GC have reported favorable short- and long-term outcomes compared with open surgery. However, LTG is more difficult due to technology than laparoscopic distal gastrectomy, reconstruction is complicated, and it has been reported that the complication rate is high in the real world[ 67 ].…”

Section: Optimal Surgical Treatment For Elderly Gcmentioning

confidence: 99%

Is surgery the best treatment for elderly gastric cancer patients?

Kawaguchi¹,

Akaike²,

Shoda³

et al. 2021

WJGS

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As the elderly population increases, the number of patients with gastric cancer has also been increasing. Elderly people have various preoperative problems such as malnutrition, high frequency of comorbidities, decreased performance status, and dementia. Furthermore, when surgery is performed, high postoperative complication rates and death from other diseases are also concerns. The goal of surgery in the elderly is that short-term outcomes are comparable to those in nonelderly, and long-term outcomes reach life expectancy. Perioperative problems in the elderly include: (1) Poor perioperative nutritional status; (2) Postoperative pneumonia; and (3) Psychological problems (dementia and postoperative delirium). Malnutrition in the elderly has been reported to be associated with increased postoperative complications and dementia, pointing out the importance of nutritional management. In addition, multidisciplinary team efforts, including perioperative respiratory rehabilitation, preoperative oral care, and early postoperative mobilization programs, are effective in preventing postoperative pneumonia. Furthermore, there are many reports on the usefulness of laparoscopic surgery for the elderly, and we considered that minimally invasive surgery would be the optimal treatment after assessing preoperative risk.

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A propensity score-matched comparison of laparoscopic distal versus total gastrectomy for middle-third advanced gastric cancer

Wang

Chen

et al. 2018

International Journal of Surgery

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Short and long-term outcomes of laparoscopic total gastrectomy for gastric cancer: A single-center experience (retrospective cohort study)

Cited by 5 publications

References 20 publications

Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy: A propensity score matching analysis

Laparoscopic vs open total gastrectomy for advanced gastric cancer following neoadjuvant therapy: A propensity score matching analysis

Is surgery the best treatment for elderly gastric cancer patients?

A propensity score-matched comparison of laparoscopic distal versus total gastrectomy for middle-third advanced gastric cancer

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