Short- and long-term neurocognitive functioning after electroconvulsive therapy in depressed elderly: a prospective naturalistic study

Verwijk, Esmée; Comijs, Hannie C.; Kok, Rob M.; Spaans, Harm-Pieter; Tielkes, Caroline E.M.; Scherder, E.J.A.; Stek, Max L.

doi:10.1017/s1041610213001932

Cited by 54 publications

(44 citation statements)

References 35 publications

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“…Our finding is consistent with previous findings obtained for younger adults (McClintock et al, 2014;Semkovska & McLoughlin, 2010) and adds important information to the few studies performed in the elderly (Gardner & O'Connor, 2008;Verwijk et al, 2014). The finding that retrograde amnesia for public facts was not evident at T3 is consistent with results of several (Meeter, Murre, Janssen, Birkenhager, & van den Broek, 2011), but not all (Lisanby et al, 2000), previous studies.…”

Section: Discussionsupporting

confidence: 93%

“…The comparison of group means revealed the absence of side effects of ECT, with the exception of declined phonemic verbal fluency. This finding was in accordance with the results of Verwijk et al (2014); these authors found no indications of cognitive side effects both within one week after ECT and six months later. However, group data might conceal cognitive side effects of ECT in a subgroup of elderly patients .…”

Section: Introductionsupporting

confidence: 92%

“…Our inclusion criteria regarding baseline cognitive function were stricter than those reported by comparable studies (O'Connor, Gardner, Eppingstall, & Tofler, 2010;Verwijk et al, 2014), some of which some did not exclude patients with moderate and severe cognitive impairment and most of which did not use a defined cut-off on a dementia rating scale as an exclusion criterion. Nevertheless, standardized scores under the seventh percentile at T1 were very common in our sample on four test measures that are highly influenced by, or that measure psychomotor speed.…”

Section: Neurocognitive Assessmentmentioning

confidence: 99%

“…They usually measure cognitive side effects at one time point within one month after a course of ECT, although it is desirable to investigate both short-term and long-term side effects. Only one previous study (Verwijk et al, 2014) has assessed the memory of elderly patients at the baseline and at two follow-ups after a course of ECT, shortly after a session of ECT (n = 42) and six months later (n = 24). Thus, additional knowledge about the durability of cognitive side effects of ECT in elderly depressed patients is needed.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Role of Baseline Cognitive Function in the Neurocognitive Effects of Electroconvulsive Therapy in Depressed Elderly Patients

Dybedal

Tanum

Bjølseth

2015

The Clinical Neuropsychologist

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Section: Discussionsupporting

confidence: 93%

Section: Introductionsupporting

confidence: 92%

Section: Neurocognitive Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Baseline Cognitive Function in the Neurocognitive Effects of Electroconvulsive Therapy in Depressed Elderly Patients

Dybedal

Tanum

Bjølseth

2015

The Clinical Neuropsychologist

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“…Verwijk et al [58] assessed cognition before and after age-formula-dosed, brief pulse ECT (RUL, BL) in both unipolar and bipolar depressed elderly participants (≥55 years, range . Improvements in global cognition and memory, and no changes in measures which assessed attention and executive function were reported after ECT.…”

Section: Ect and Cognition In The Elderlymentioning

confidence: 99%

Neuromodulation Therapies for Geriatric Depression

Gálvez

Alonzo

et al. 2015

Curr Psychiatry Rep

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Depression is frequent in old age and its prognosis is poorer than in younger populations. The use of pharmacological treatments in geriatric depression is limited by specific pharmacodynamic age-related factors that can diminish tolerability and increase the risk of drug interactions. The possibility of modulating cerebral activity using brain stimulation techniques could result in treating geriatric depression more effectively while reducing systemic side effects and medication interactions. This may subsequently improve treatment adherence and overall prognosis in the older patient. Among clinically available neuromodulatory techniques, electroconvulsive therapy (ECT) remains the gold standard for the treatment of severe depression in the elderly. Studies have proven that ECT is more effective and has a faster onset of action than antidepressants in the treatment of severe, unipolar, geriatric depression and that older age is a predictor of rapid ECT response and remission. The application of novel and more tolerable forms of ECT for geriatric depression is currently being examined. Preliminary results suggest that right unilateral ultrabrief ECT (RUL-UB ECT) is a promising intervention, with similar efficacy to brief-pulse ECT and fewer adverse cognitive effects. Overall findings in repetitive transcranial magnetic stimulation (rTMS) suggest that it is a safe intervention in geriatric depression. Higher rTMS stimulation intensity and more treatments may need to be given in the elderly to achieve optimal results. There is no specific data on vagus nerve stimulation in the elderly. Transcranial direct current stimulation, magnetic seizure therapy and deep brain stimulation are currently experimental, and more data from geriatric samples is needed.

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Subanesthetic dose of ketamine for the antidepressant effects and the associated cognitive impairments of electroconvulsive therapy in elderly patients—A randomized, double‐blind, controlled clinical study

et al. 2020

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Objectives We previously confirmed that low‐dose ketamine, as an adjunctive anesthetic for electroconvulsive therapy (ECT) in adult patients with depression, accelerates the effects of ECT and reduces the ECT‐induced learning and memory deficits. This study explored the efficacy and safety of low‐dose ketamine in elderly patients with depression. Methods Elderly patients with depression (N = 157) were randomly divided into two groups: propofol anesthesia group (group P) and propofol combined with ketamine anesthesia group (group KP). Patients in group KP were given low‐dose ketamine (0.3 mg/kg) for each ECT treatment; patients in group P were given the same amount of normal saline. Depressive symptoms and global cognitive functions were assessed using the 24‐item Hamilton Depression Rating Scale and Mini‐Mental State Examination, respectively, at baseline, 1 day after the 1st, 2nd, 4th, and 6th ECT sessions, and 1 day after the end of the ECT course. ECT effects of and complications were recorded. Results In total, 67 patients in group KP and 70 in group P completed the study. After the ECT, the response and remission rates were 82.09% and 73.13%, respectively, in group KP, and 81.43% and 68.57%, respectively, in group P; there was no statistical difference between groups. However, the incidence of cognitive function impairment was lower in group KP (10.4%) than in group P (25.7%), while different electrical dose and seizure duration were required during the course of treatment between the two groups. There was no difference in the complications of ECT between groups. Conclusions Low‐dose ketamine is safe as an adjunct anesthetic for elderly patients subjected to ECT. It has a protective effect on cognitive function and may accelerate the antidepressant effects of ECT.

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Short- and long-term neurocognitive functioning after electroconvulsive therapy in depressed elderly: a prospective naturalistic study

Cited by 54 publications

References 35 publications

The Role of Baseline Cognitive Function in the Neurocognitive Effects of Electroconvulsive Therapy in Depressed Elderly Patients

The Role of Baseline Cognitive Function in the Neurocognitive Effects of Electroconvulsive Therapy in Depressed Elderly Patients

Neuromodulation Therapies for Geriatric Depression

Subanesthetic dose of ketamine for the antidepressant effects and the associated cognitive impairments of electroconvulsive therapy in elderly patients—A randomized, double‐blind, controlled clinical study

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