Short and long-term mortality in severe sepsis/septic Shock in a setting with low antibiotic resistance centers

Abstract

Background: Sepsis, which is a common inflammatory response to severe infection, is one of the major causes of mortality in hospitalized patients. Sepsis, severe sepsis or sepsis syndrome, and eventually septic shock, may be seen in the development of infection. The aim of this study was to evaluate the short-term and long-term mortality in patients with severe sepsis and septic shock in centers with low antibiotic resistance. Methods: In this cross-sectional study, blood culture samples and peripheral blood samples were taken from all patients for para-clinical tests. The severity of severe sepsis and septic shock was assessed by the APACHE II and SOFA clinical criteria. Sepsis risk factors and primary causes of sepsis were recorded. Results: From 100 patients, 55% had severe sepsis and 45% had septic shock. SOFA24h and SOFA96h scores were significantly higher in patients with septic shock. The most common primary cause of sepsis was related to abdominal infections with a frequency of 42%. The frequency of confirmed positive blood culture was 53%. The most commonly isolated pathogen was E.coli with a frequency of 66%. Short-term mortality was 29% and long-term mortality was 28.2%. Conclusion: The main risk factors affecting the mortality of patients were age-related septic shock, cardiovascular disease; hypertension, immunosuppression, and SOFA score.

What are the independent parameters associated with increased mortality risk in patients with severe sepsis or septic shock in the intensive care unit?

“…Population-based national mortality registries have also shown supporting data, for instance Weng et al found that comorbidities increase mortality from sepsis, independent of other variables [24]. In addition, different studies have shown that kidney injury [25] and heart failure [14,26] are prominent factors independently associated with mortality in patients with sepsis. In our study, in agreement with these studies, the presence of chronic heart failure, cardiovascular failure, renal failure and the number of organ failures on the first day of admission were found to be associated with an elevated risk of mortality.…”