Short- and long-term histopathologic evaluation of stenting using a self-expanding nitinol stent in pig carotid and iliac arteries

Verheye, Stefan; Salame, Mahomed Y.; Robinson, Keith A.; Post, Mark J.; Carrozza, Joseph P.; Baim, Donald S.; Sigwart, Ulrich; King, Spencer B.; Chronos, Nicolas

doi:10.1002/(sici)1522-726x(199911)48:3<316::aid-ccd19>3.0.co;2-w

Cited by 28 publications

(20 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In terms of histology, size and cellular density this is similar to what happens in humans 13,16 . Verheye et al 20 , after implanting stents in the iliac and carotid arteries of pigs, conducted histological studies of one to six months, stating that within one month the vascular wall was completely covered by endothelial-type cells. In our laboratory, we have studied the intimal tickening in a series of conditions and the time interval of four weeks was used to study the arterial wall alterations 7 .…”

Section: Discussionmentioning

confidence: 99%

Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

Jùnior¹,

Pereira

Pasa³

2006

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE: To compare through digital morphometry, the intimal thickening of the common ilíac arteries (CIA) in pigs, submitted to angioplasty and angioplasty followed by stent implantation. METHODS: Angioplasty was performed in 10 pigs in both CIA, followed by a stent implantation in the left CIA. After four weeks, the aorto-iliac segment was dissected. Histologic slices where divided in three groups: left CIA in the area of the proximal (group 1) and distal (group 2) implantation site of the stent and the region of angioplasty in the right CIA (group 3). The histological slices were digitalized to be analyzed by morphometry with calculation of the luminal, intimal and media layers areas. Descriptive statistics analysis was performed through average and standard deviation of areas on each group, using ANOVA, with LSD Post-Hoc test (p<0.05). RESULTS: A significant statistic difference was observed when the median area of intimal layer of the groups 1 and 2 where compared with group 3 and in the media layer area of the groups 1 and 2 when compared with group 3. No difference was observed in luminal areas among the three groups. CONCLUSION: Angioplasty followed by stent insertion produces an intimal thickening larger than that observed after simple angioplasty. However, the area of the media layer is smaller in the "angioplasty plus stent" group and there is no significant change in the luminal area among the three groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

Jùnior¹,

Pereira

Pasa³

2006

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Self-expanding stents had some characteristics such as invulnerability to compression, precise deployment and high-vessel wall surface coverage, which may be advantageous for maintaining vessel patency. 18 Hence, after self-expanding stents came to our hospital, they were selected in subsequent patients. Third, corticosteroid maintenance and regular follow-up: As TA is a progressive inflammatory disease, corticosteroid and regular follow-up are needed to prevent restenosis and new lesions.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous Transluminal Angioplasty and Stenting for Pulmonary Stenosis Due to Takayasu's Arteritis: Clinical Outcome and Four‐year Follow‐up

Luo

Zhang

Liu

et al. 2009

Clinical Cardiology

View full text Add to dashboard Cite

Background: Percutaneous transluminal angioplasty and stent implantation for stenotic lesions of renal arteries and other branches of the aorta in Takayasu's arteritis have been reported to show good outcomes. However, this form of therapy has been reported in few cases with pulmonary artery involvement. Hypothesis: The aim of this study was to evaluate the role of this interventional treatment for pulmonary stenosis due to Takayasu's arteritis. Methods: A total of 4 patients (3 female and 1 male, ages 30-40 yrs) with Takayasu's pulmonary arteritis underwent percutaneous transluminal balloon angioplasty and stent implantation and were followed up for 1 to 4 years. Results: One patient underwent balloon angioplasty alone, 3 patients underwent balloon angioplasty and stent implantation. The stenoses were relieved acutely, oxygen saturation improved immediately due to improvement in lung perfusion and relief of dyspnea. The pressure gradient fell from 58.3 ± 8.7 mm Hg to 14 ± 3.2 mm Hg and mean pulmonary arterial pressure decreased from 48.5 ± 12.0 mm Hg to 37.3 ± 6.0 mm Hg. At a follow-up period of 34.5 ± 15.8 months, the patient with balloon angioplasty alone developed a recurrence of symptoms 18 months after the procedure. The other 3 patients continued to be asymptomatic and the stent remained patent without restenosis after the procedure. Conclusion: Percutaneous transluminal angioplasty and stent implantation is a safe and effective treatment in patients with pulmonary stenosis caused by Takayasu's arteritis.

show abstract

“…8 Nitinol (nickel ,55%, titanium ,45%) experimentally may produce less damage and platelet activation than stainless steel but has mechanical qualities that better suit it to self expanding stents as opposed to a balloon expandable delivery. 9 The use of cobalt/chromium alloys allows stent designs (S8/Driver Medtronic Ave and Multilink Vision, Guidant) to utilise thinner struts while maintaining radial strength and radio-opacity. 10 Reduced strut thickness has been shown to be associated with reduced restenosis and registry data with Guidant's Multilink Vision is encouraging with a six month binary restenosis rate of 15.7%.…”

Section: Alternative To Stainless Steel: Tantalum Nitinol and Cobalt mentioning

confidence: 99%

Coronary stents: in these days of climate change should all stents wear coats?

Lowe

Menown²,

Nogareda³

et al. 2005

Heart

View full text Add to dashboard Cite

Short- and long-term histopathologic evaluation of stenting using a self-expanding nitinol stent in pig carotid and iliac arteries

Cited by 28 publications

References 26 publications

Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

Morphometric analysis of the intimal reaction after stent implantation in iliac arteries submitted to angioplasty in pigs

Percutaneous Transluminal Angioplasty and Stenting for Pulmonary Stenosis Due to Takayasu's Arteritis: Clinical Outcome and Four‐year Follow‐up

Coronary stents: in these days of climate change should all stents wear coats?

Contact Info

Product

Resources

About