Short- and long-term follow-up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine

Hoek, Ingrid van; Lefebvre, Henri; Peremans, K.; Meyer, Evelyne; Croubels, Siska; Vandermeulen, Eva; Kooistra, Hans S.; Saunders, Jimmy; Binst, Dominique; Daminet, Sylvie

doi:10.1016/j.domaniend.2008.10.001

Cited by 59 publications

(67 citation statements)

References 39 publications

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“…While the various methods of measuring iohexol in plasma produce consistent results over a variety of GFRs, variation exists between the absolute values obtained with each (Brown et al, 1996a; Finco et al, 2001; Miyamoto, 2001b). In addition, further investigation is necessary to determine which iohexol assay should be used when determining GFR, as results of endo- and exo-iohexol (the two stereoisomers of iohexol) assays have been significantly different from each other in recent studies, and may be due to higher reproducibility, and therefore accuracy, of exo-iohexol HPLC assays (Le Garreres et al, 2007; van Hoek et al, 2007; van Hoek et al, 2008; van Hoek et al, 2009b). …”

Section: Markers and Techniques For Gfr Determinationmentioning

confidence: 99%

An overview of glomerular filtration rate testing in dogs and cats

Hendy-Willson

Pressler

2011

The Veterinary Journal

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Determination of glomerular filtration rate (GFR) is a valuable, yet underused, diagnostic tool for evaluating renal function in dogs and cats. This article first reviews the hormonal and hemodynamic factors which contribute to GFR, followed by a description of considerations when selecting a pharmacokinetic model and methods of animal-to-animal standardization. The bestcharacterized existing GFR markers, including creatinine, radiolabeled markers, and iohexol, are reviewed in depth, as well as alternative but lesser-used techniques. A weighted means analysis of reported GFR measurements in healthy dogs and cats and a review of selected studies that have examined GFR alterations in animals with naturally-occurring and experimental diseases provide the reader with preliminary guidelines on expected GFR results in these species and disease conditions.

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Section: Markers and Techniques For Gfr Determinationmentioning

confidence: 99%

An overview of glomerular filtration rate testing in dogs and cats

Hendy-Willson

Pressler

2011

The Veterinary Journal

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“…Cats with hyperthyroidism have been shown to be more markedly proteinuric and that this proteinuria resolves with treatment of hyperthyroidism. 45 Proteinuria is present as a consequence of glomerular hypertension and it can be hypothesized that this in addition to protein processing by the proximal tubular cells (see below) may be detrimental to the kidney.…”

Section: Association Of the Development Of Chronic Kidney Disease Witmentioning

confidence: 99%

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Jepson

2016

Veterinary Clinics of North America: Small Animal Practice

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Abstract:In cats with chronic kidney disease (CKD), the most common histopathological finding is tubulointerstitial inflammation and fibrosis. However, these changes reflect a non-specific response of the kidney to any inciting injury. The risk of development of CKD in a patient is likely to reflect genetic predispositions, ageing, environmental and individual factors that influence decline in renal function over the course of a cat's life. However, there is still relatively little information about exactly which risk factors predispose a cat to develop CKD and these will be explored. Whilst many cats diagnosed with CKD have stable disease for many years, some cats show overtly progressive disease.

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“…10 These markers may not only allow early diagnosis of primary renal disease, they are also able to detect subclinical renal dysfunction secondary to infectious or endocrine disorders (e.g., pyometra, leishmaniasis, hyperthyroidism, and Cushing's disease). 9,12,20,31 In order to perform reliable clinical studies using urinary markers, urine samples need to be collected and stored in optimal conditions to preserve protein integrity and enzyme activity. Studies evaluating the effect of sampling method and storage conditions on determination of urinary markers are lacking in veterinary medicine and therefore mandatory.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sampling Method and Storage Conditions on Albumin, Retinol-Binding Protein, And N-Acetyl-β-D-Glucosaminidase Concentrations in Canine Urine Samples

et al. 2010

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Abstract. Urinary markers for renal dysfunction are gaining interest, but effects of sampling method, storage conditions, and urinary tract inflammation or infection on these markers are unclear. Therefore, the objectives of the current study were to determine the difference in urinary albumin (uALB), urinary retinolbinding protein (uRBP), and urinary N-acetyl-b-D-glucosaminidase (uNAG) concentrations in cystocentesis and voided samples and to investigate concentration changes after storage at 220uC and at 280uC. Effects of a protease inhibitor were also assessed in samples stored at 280uC for 12 months. In a pilot experiment, influence of in vitro hematuria, pyuria, and bacteriuria on the urinary markers was evaluated. A mixed model was used to calculate mean differences and 95% confidence intervals. Urinary ALB, uNAG, and uRBP concentrations were similar in voided and cystocentesis samples. After storage for 4 months at 220uC, uALB concentration was not affected, and uRBP concentration showed a mild and clinically irrelevant decrease, whereas uNAG activity was significantly lower compared with fresh samples. After storage for 12 months at 280uC, uALB and uRBP concentrations did not differ from fresh samples, but uNAG activity was severely decreased. Protease inhibitor addition did not preserve uNAG activity. Experimental hematuria, pyuria, and bacteriuria did not seem to affect urinary markers, although further research is needed.

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Short- and long-term follow-up of glomerular and tubular renal markers of kidney function in hyperthyroid cats after treatment with radioiodine

Cited by 59 publications

References 39 publications

An overview of glomerular filtration rate testing in dogs and cats

An overview of glomerular filtration rate testing in dogs and cats

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Effect of Sampling Method and Storage Conditions on Albumin, Retinol-Binding Protein, And N-Acetyl-β-D-Glucosaminidase Concentrations in Canine Urine Samples

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