2019
DOI: 10.1016/j.envpol.2019.03.100
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Short and long-term effects of bisphenol S (BPS) exposure during pregnancy and lactation on plasma lipids, hormones, and behavior in rats

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Cited by 49 publications
(22 citation statements)
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“…Regarding progesterone, previous studies have shown a lower level of progesterone in the circulating plasma of rats exposed to BPS ( 43 ). This is relevant to the decrease in plasma progesterone observed in restricted ewes after BPS exposure.…”
Section: Discussionmentioning
confidence: 94%
“…Regarding progesterone, previous studies have shown a lower level of progesterone in the circulating plasma of rats exposed to BPS ( 43 ). This is relevant to the decrease in plasma progesterone observed in restricted ewes after BPS exposure.…”
Section: Discussionmentioning
confidence: 94%
“…Although we cannot be sure, it seems likely that the effects noted (e.g., on neurotransmitter levels) persist until parturition, and it does not seem unreasonable to infer that these changes directly influence fetal brain development, possibly leading to permanent neurobehavioral effects. We and others have shown that developmental exposure of fetuses in various rodent models to BPA/BPS can alter later neurobehavioral responses (76,80,81,(83)(84)(85)(86)(87). To tease apart potential BPA/BPS-induced effects through the placental-brain axis vs. direct effects on the fetal brain, it may be necessary to create conditional knockout mice that lack BPA/BPS-responsive genes in the GCs and spongiotrophoblast.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, while temephos produced permanent damage in metabolically competent HepG2 cells, reversible DNA damage was observed in human lymphocytes, which have a very low metabolic activity . The formation of BPS from the temephos biotransformation also suggests possible reproductive effects, since this compound is classified as an endocrine disruptor on the basis of its properties as an estrogen receptor agonist. , Thus, the temephos biotransformation may generate several metabolites, all of which have a wide range of toxicity. To date, it is difficult to propose which temephos metabolites are responsible for certain effects because of the lack of metabolic pathway information in different species, including humans.…”
Section: Discussionmentioning
confidence: 99%