Short‐ and long‐term effects of (+)‐methamphetamine and (±)‐3,4‐methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment

Schaefer, Tori L.; Skelton, Matthew R.; Herring, Nicole R.; Gudelsky, Gary A.; Vorhees, Charles V.

doi:10.1111/j.1471-4159.2007.05112.x

Cited by 43 publications

(67 citation statements)

References 61 publications

(81 reference statements)

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“…Alternatively, the lack of cholinergic receptor changes in other brain areas, such as the cortex, may leave sensorimotor gating and attention behavior intact in adulthood following postnatal MA exposure. Although not measured in the current study, MA exposure during brain development has been shown to alter both dopaminergic (Heller et al , 2001a,b; Crawford et al , 2003) and serotonergic (Won et al , 1992, 2002; Weissman and Caldecott-Hazard 1993; Schaefer et al , 2007) function immediately after exposure and later in life in both cell cultures and rodents. As both of these neurotransmitters interact with the cholinergic system (Day and Fibiger 1992; Gaykema and Zaborszky 1996; Kenny et al , 2000; Bitner and Nikkel 2002; Berlanga et al , 2005), the effects of MA on cognition may be partially due to long-term changes in the dopamine and serotonin systems.…”

Section: Discussionmentioning

confidence: 69%

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Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Siegel¹,

Craytor²,

Raber³

2010

Behavioural Pharmacology

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Exposure to methamphetamine during brain development impairs cognition in humans and rodents. In mice, these impairments are greater in females than males. Genetic factors, such as apolipoprotein E genotype, may modulate the cognitive effects of methamphetamine. Methamphetamine-induced alterations in the brain acetylcholine system may contribute to the cognitive effects of methamphetamine and may also be modulated by apolipoprotein E isoform. We assessed the long-term effects of methamphetamine exposure during brain development on cognitive function and muscarinic acetylcholine receptors in mice, and whether apolipoprotein E isoform modulates these effects. Mice expressing human apolipoprotein E3 or E4 were exposed to methamphetamine (5 mg/kg) or saline once a day from postnatal day 11-20 and behaviorally tested in adulthood. Muscarinic acetylcholine receptor binding was measured in the hippocampus and cortex. Methamphetamine exposure impaired novel location recognition in female, but not male, mice. Methamphetamine-exposed male and female mice showed impaired novel object recognition and increased number of muscarinic acetylcholine receptors in the hippocampus. The cognitive and cholinergic effects of methamphetamine were similar in apolipoprotein E3 and E4 mice. Thus, the cholinergic system, but not apolipoprotein E isoform, might play an important role in the long-term methamphetamine-induced cognitive deficits in adulthood.

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Section: Discussionmentioning

confidence: 69%

“…MA exposure during brain development affects multiple neurotransmitter systems, including the dopamine and serotonin systems (Won et al , 1992, 2002; Weissman and Caldecott-Hazard 1993; Heller et al , 2001a,b; Crawford et al , 2003; Schaefer et al , 2007). Although less well known, MA also affects the brain acetylcholine (ACh) system.…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Siegel¹,

Craytor²,

Raber³

2010

Behavioural Pharmacology

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“…Following an average of 8 months of abstinence, adolescents who used MA for an average of 2.4 years show increased cortisol levels following a social stressor compared to controls [8]. Neonatal MA exposure in rodents from either postnatal day (PND) 11–15 or PND 11–20 is associated with large and prolonged increases in corticosterone and/or adrenocorticotropic releasing hormone immediately following exposure [17, 22–24]. However, challenges to the HPA axis during brain development can lead to long-term impairments in the system later in life.…”

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confidence: 99%

Long-Term Effects of Early Adolescent Methamphetamine Exposure on Depression-Like Behavior and the Hypothalamic Vasopressin System in Mice

Joca

Zuloaga²,

Raber³

et al. 2014

Dev Neurosci

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Methamphetamine (MA) has neurotoxic effects on the adult human brain that can lead to deficits in behavior and cognition. However, relatively little research has examined the behavioral or neurotoxic effects of MA in adolescents. The rising rates of adolescent MA use make it imperative that we understand the long-term effects of MA exposure on the adolescent brain and how these effects may differ from those seen in adults. In this study, the long-term effects of MA exposure during early adolescence on behavior and the vasopressin system in the paraventricular nucleus of the hypothalamus in late adolescent and adult male and female C57BL/6J mice were examined. MA exposure increased depression-like behavior in the Porsolt forced swim test in both late adolescent and adult male and female mice. Late adolescent male mice exposed to MA also showed a decrease in the number of vasopressin-immunoreactive neurons in the paraventricular nucleus compared to sex-matched saline-treated controls. Thus, similar to humans exposed to MA during adolescence, mice exposed to MA during adolescence show increased depression-like behavior later in life. These changes in behavior may be related to MA-induced alterations in vasopressin and the hypothalamic-pituitary-adrenal axis, especially in males.

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“…Foxy has effects on 5-HT systems in the brain, acting on the 5-HT2A receptor [123] as a SERT inhibitor [124]. An increase in corticosterone is associated with MDMA exposure in neonatal [125], young [126], and adult rats [127] [128]. Foxy, too, seems to increase corticosterone levels in preweaned and in adult rats [129] [130] but not if introduced during adolescence [129].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Examination of Learning and Memory in Rats Following Adolescent Exposure to 3,4-Methylenedioxymethamphetamine or 5-Methoxy-N,N-Diisopropyltryptamine

Compton¹,

Dietrich²,

Esquivel³

2017

JBBS

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A drug of abuse, Foxy or Methoxy Foxy gained popularity among recreational users as an alternative to MDMA (Ecstasy). Considerable research into the consequences of MDMA use is available, yet much remains unknown about the neurobiological consequences of Foxy use. In addition, research into the long-term neuropsychological repercussions associated with these two compounds remains incomplete. The goal of the present research was to explore the effects of MDMA or Foxy on cognitive processes associated with adolescent exposure considered over much of the lifespan. Here we investigated whether the reported effects following adolescent exposure resolved in early adulthood or continued throughout life. The protocol involved repeated doses of either MDMA or Foxy during the period defined as mid-adolescence (postnatal days 34 -46) in rats, followed by the use of four series of learning and memory tasks repeated at different points in the rodent lifespan. At four time points in adulthood, the animals were trained and tested on a on a series of spatial and nonspatial memory tasks designed to assess the impact and severity of Foxy and MDMA. Oddly, MDMA-treated rats were impaired on a step down passive avoidance task. The performance of the drug-treated rats was markedly inferior to that of the control animals on more demanding water maze tasks, with some results suggesting a lack of flexibility in adapting to changing task demands. MDMA rats were the most impaired. While some persistent cognitive deficits were found, no significant group differences in serotonin or dopamine levels were found in any of the measured regions of the brain changes, cortical or subcortical. These results provide evidence for compromised neurocognition that continues long after drug exposure in the How to cite this paper:

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Short‐ and long‐term effects of (+)‐methamphetamine and (±)‐3,4‐methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment

Cited by 43 publications

References 61 publications

Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Long-Term Effects of Early Adolescent Methamphetamine Exposure on Depression-Like Behavior and the Hypothalamic Vasopressin System in Mice

Longitudinal Examination of Learning and Memory in Rats Following Adolescent Exposure to 3,4-Methylenedioxymethamphetamine or 5-Methoxy-N,N-Diisopropyltryptamine

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