Short- and Long-term Effects of Irradiation on Laryngeal Mucosa of the Rat

Lidegran, Sture Forsgren Mats Mats

doi:10.1080/028418699432400

Cited by 8 publications

(1 citation statement)

References 30 publications

(39 reference statements)

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“…Adequate hydration of the larynx has also been proposed, considering the damaging effect of radiation on laryngeal salivary glands and mucosa leading to vocal folds dryness [195,197]. In fact, Substance P, bombesin and enkephalin are upregulated in the innervation of these glands, suggesting a possible neurogenic root for voice impairment [198,199]. Management of dysphonia includes non-pharmacological treatment modalities such as speech therapy.…”

Section: Dysphagia and Dysphoniamentioning

confidence: 99%

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

Azzam¹,

Mroueh²,

Francis³

et al. 2020

ecancer

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Head and neck cancer (HNC) is the sixth most common human malignancy with a global incidence of 650,000 cases per year. Radiotherapy (RT) is commonly used as an effective therapy to treat tumours as a definitive or adjuvant treatment. Despite the substantial advances in RT contouring and dosage delivery, patients suffer from various radiation-induced complications, among which are toxicities to the nervous tissues in the head and neck area. Radiation-mediated neuropathies manifest as a result of increased oxidative stress-mediated apoptosis, neuroinflammation and altered cellular function in the nervous tissues. Eventually, molecular damage results in the formation of fibrotic tissues leading to susceptible loss of function of numerous neuronal substructures. Neuropathic sequelae following irradiation in the head and neck area include sensorineural hearing loss, alterations in taste and smell functions along with brachial plexopathy, and cranial nerves palsies. Numerous management options are available to relieve radiation-associated neurotoxicities notwithstanding treatment alternatives that remain restricted with limited benefits. In the scope of this review, we discuss the use of variable management and therapeutic modalities to palliate common radiation-induced neuropathies in head and neck cancers.

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Section: Dysphagia and Dysphoniamentioning

confidence: 99%

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

Azzam¹,

Mroueh²,

Francis³

et al. 2020

ecancer

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In vivo and in vitro models of ionizing radiation to the vocal folds

et al. 2010

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Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man

Danielson

Alfredson

Forsgren

2007

Microscopy Res & Technique

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Changes in the patterns of production and in the effects of signal substances may be involved in the development of tendinosis, a chronic condition of pain in human tendons. There is no previous information concerning the patterns of sympathetic innervation in the human patellar tendon. In this study, biopsies of normal and tendinosis patellar tendons were investigated with immunohistochemical methods, including the use of antibodies against tyrosine hydroxylase (TH) and neuropeptide Y, and against alpha1-, alpha2A-, and beta1-adrenoreceptors. It was noticed that most of the sympathetic innervation was detected in the walls of the blood vessels entering the tendon through the paratendinous tissue, and that the tendon tissue proper of the normal and tendinosis tendons was very scarcely innervated. Immunoreactions for adrenergic receptors were noticed in nerve fascicles containing both sensory and sympathetic nerve fibers. High levels of these receptors were also detected in the blood vessel walls; alpha1-adrenoreceptor immunoreactions being clearly more pronounced in the tendinosis tendons than in the tendons of controls. Interestingly, immunoreactions for adrenergic receptors and TH were noted for the tendon cells (tenocytes), especially in tendinosis tendons. The findings give a morphological correlate for the occurrence of sympathetically mediated effects in the patellar tendon and autocrine/paracrine catecholamine mechanisms for the tenocytes, particularly, in tendinosis. The observation of adrenergic receptors on tenocytes is interesting, as stimulation of these receptors can lead to cell proliferation, degeneration, and apoptosis, events which are all known to occur in tendinosis. Furthermore, the results imply that a possible source of catecholamine production might be the tenocytes themselves

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Short- and Long-term Effects of Irradiation on Laryngeal Mucosa of the Rat

Cited by 8 publications

References 30 publications

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

Radiation-induced neuropathies in head and neck cancer: prevention and treatment modalities

In vivo and in vitro models of ionizing radiation to the vocal folds

Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man

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